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Dlugos discusses selection criteria for the early identification of candidates for epilepsy surgery. Issues including prognosis, medical intractability, and the benefits and risks of early surgery are reviewed. The effectiveness of epilepsy surgery is clear, as he points out, but challenging work remains to be done to clarify and optimize the timing of surgery for epilepsy, especially in children and adolescents.
Faden reviews clinical and pharmacological studies in experimental animals and patients, defining the issues and therapies that protect against traumatic brain injury. Issues including the therapeutic window, pharmacokinetics, and brain drug penetration will become increasingly more important in future studies.
This Month in Archives of Neurology. Arch Neurol. 2001;58(10):1530–1531. doi:10.1001/archneur.58.10.1530
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