Physicians in the United States, Canada, and Mexico
Physicians with current and valid licenses in the United States, Canada, or Mexico who read any 3 of the selected continuing medical education (CME) articles in this issue of Archives of Neurology, complete the CME Evaluation Form, and fax it to the number or mail it to the address at the bottom of the CME Evaluation Form are eligible for category 1 CME credit. There is no charge.
The American Medical Association (AMA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians. The AMA designates this educational activity for up to 3 hours of category 1 CME credit per Archives of Neurology issue toward the AMA Physician's Recognition Award (PRA). Each physician should claim only those hours of credit that were actually spent in this educational activity.
Physicians in Other Countries
Physicians with current and valid licenses in the United States, Mexico, or Canada are eligible for CME credit even if they live or practice in other countries. Physicians licensed in other countries are also welcome to participate in this CME activity. However, the PRA is only available to physicians licensed in the United States, Canada, or Mexico.
Statement of Educational Purpose
The Archives of Neurology provides new evidence for the practice of neurology, neurosurgery, and other specialties whose goal is to improve the neurological health of all people. Original contributions, neurological reviews, neurology and public health, and history of neurology are among the categories of articles published, but all contributions receive a sympathetic reading by the Chief Editor. The journal's editorial board sets the initial framework for the types of articles published, which is then modified by feedback from editors, external peer reviewers, authors, and readers. We are keen to receive submissions from practicing neurologists to provide new insight for colleagues.
We want our readers to assess each article critically; this CME activity is active, not passive. Does the article contribute in some way to the practice of neurology? How could you modify your practice style to incorporate what you have learned? How can you acquire more information, challenge the authors' conclusions, or verify what you have read? Which of the articles in each issue is least helpful in your quest for the best and most applicable evidence?
To earn 1 hour of category 1 CME credit, you should read any 3 of the CME articles listed below and complete the CME Evaluation Form. To earn 3 hours of credit, read all of the articles listed below and complete the CME Evaluation Form. The CME Evaluation Form must be submitted within 4 weeks of the issue date. A certificate awarding up to 3 hours of category 1 CME credit will be faxed or mailed to you; it is then your responsibility to maintain a record of credit received. Questions about CME credit processing should be directed to The Blackstone Group; tel: (312) 419-0400, ext 225; fax: (312) 269-1636.
One of our goals is to assess continually the needs of our readers so we may enhance the educational effectiveness of the Archives of Neurology. To achieve this goal, we need your help. You must complete the CME Evaluation Form to receive credit.
CME Articles in This Issue of Archives of Neurology
The articles listed below may be read for CME credit.
Sequence Analysis of the Human Genome: Implications for the Understanding of Nervous System Function and Disease
Educational Objective: To achieve an understanding of the impact that the human genome sequence will have in defining neurological functions and causes of disease.
Current Understanding of the Circadian Clock and the Clinical Implications for Neurological Disorders
Educational Objective: To recognize the role of the circadian clock in neurological disorders.
Polymorphisms in Inflammatory Genes and the Risk of Alzheimer Disease
Educational Objective: To identify neurogenetic evidence about inflammation as a risk factor in Alzheimer disease.
Feasibility of Gene Therapy for Late Neuronal Ceroid Lipofuscinosis
Educational Objective: To summarize new therapies for late infantile neuronal ceroid lipofuscinosis.
Clinical and Pathological Diagnosis of Frontotemporal Dementia: Report of the Work Group on Frontotemporal Dementia and Pick's Disease
Educational Objective: To understand guidelines for the diagnosis of frontotemporal dementia.
The Genetic and Pathological Classification of Familial Frontotemporal Dementia
Educational Objective: To explore the genetic and pathological basis of frontotemporal dementia.
α-Synuclein in Familial Alzheimer Disease: Epitope Mapping Parallels Dementia With Lewy Bodies and Parkinson Disease
Educational Objective: To investigate the α-synuclein epitope mapping properties of Lewy bodies in familial Alzheimer disease.
Improvement in the Molecular Diagnosis of Machado-Joseph Disease
Educational Objective: To recognize advances in the diagnosis of Machado-Joseph disease.
Impact of DNA Testing for Early-Onset Familial Alzheimer Disease and Frontotemporal Dementia
Educational Objective: To understand the personal and social impact of DNA testing in neurologic disorders.
TheSCA12Mutation as a Rare Cause of Spinocerebellar Ataxia
Educational Objective: To investigate the relative frequency of SCA12 among familial and sporadic spinocerebellar ataxias.
Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 6: A Study of 24 Dutch Families
Educational Objective: To examine SCA6 mutations in spinocerebellar ataxias in the Netherlands.
Familial Progressive Supranuclear Palsy: Detection of Subclinical Cases Using 18F-Dopa and 18Fluorodeoxyglucose Positron Emission Tomography
Educational Objective: To study regional dopaminergic and glucose metabolism in familial progressive supranuclear palsy.
Genetic and Clinical Analysis of Spinocerebellar Ataxia Type 8 Repeat Expansion in Italy
Educational Objective: To determine the prevalence of SCA8 repeat expansion in spinocerebellar ataxias.
Dorsal Forebrain Anomaly in Williams Syndrome
Educational Objective: To examine forebrain anomalies in Williams syndrome.
TAUas a Susceptibility Gene for Amyotropic Lateral Sclerosis–Parkinsonism Dementia Complex of Guam
Educational Objective: To study TAU protein in amyotrophic lateral sclerosis–parkinsonism dementia complex among Chamorro people of Guam.
Identification of a High Frequency of Mutation at Exon 8 of theATP7BGene in a Chinese Population With Wilson Disease by Fluorescent PCR
Educational Objective: To learn more about the neurogenetics of Chinese patients with Wilson disease.
Hearing Impairment Is Common in Various Phenotypes of the Mitochondrial DNA A3243G Mutation
Educational Objective: To study the clinical correlation of the mitochondrial DNA A3243G mutation.
After you have read any 3 (to earn 1 hour of category 1 CME credit) or all (to earn 3 hours of credit) of these articles, please complete the CME Evaluation Form.