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Although the diagnosis of Creutzfeld-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD.
To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD.
Materials and Methods
Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist.
Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes.
Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.
Mittal S, Farmer P, Kalina P, Kingsley PB, Halperin J. Correlation of Diffusion-Weighted Magnetic Resonance Imaging With Neuropathology in Creutzfeldt-Jakob Disease. Arch Neurol. 2002;59(1):128–134. doi:10.1001/archneur.59.1.128
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