Correlation of Diffusion-Weighted Magnetic Resonance Imaging With Neuropathology in Creutzfeldt-Jakob Disease | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network
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Observation
January 2002

Correlation of Diffusion-Weighted Magnetic Resonance Imaging With Neuropathology in Creutzfeldt-Jakob Disease

Author Affiliations

From the Departments of Neurology (Drs Mittal and Halperin), Pathology (Dr Farmer), and Radiology (Drs Kalina and Kingsley), North Shore University Hospital, Manhasset, NY; and New York University School of Medicine, New York.

Arch Neurol. 2002;59(1):128-134. doi:10.1001/archneur.59.1.128
Abstract

Background  Although the diagnosis of Creutzfeld-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD.

Objective  To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD.

Materials and Methods  Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist.

Results  Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes.

Conclusion  Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.

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