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This Month in Archives of Neurology
June 2002

This Month in Archives of Neurology

Arch Neurol. 2002;59(6):907-908. doi:10.1001/archneur.59.6.907

Shuren and Grafman provide a thoughtful review of our current understanding of the cognitive basis of reasoning. Clearly, a better understanding of the basic mechanisms and subprocesses of reasoning should make it possible to evaluate reasoning abilities in different neurologic disorders.

Ellis and colleagues find that elevated human immunodeficiency virus (HIV) RNA levels in cerebrospinal fluid (CSF) (>200 copies/mL) predict subsequent progression to cognitive impairment. Monitoring CSF viral load and therapy to reduce HIV RNA levels in CSF may be of clinical value. Editorial comment is provided by Kenneth L. Tyler, MD, and Justin C. McArthur, MBBS, MPH.

Álvarez-Lafuente and colleagues present persuasive data in support of the view that there is a an active human herpesvirus 6 variant A infection in a statistically significant number of patients with multiple sclerosis. The significance of this finding and its pathogenic significance are reviewed.