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This Month in Archives of Neurology
September 2002

This Month in The Archives of Neurology

Arch Neurol. 2002;59(9):1362-1363. doi:10.1001/archneur.59.9.1362

"It is tough to make predictions—particularly about the future," said Yogi Berra. Guy M. McKhann, MD, offers his predictions for the future of neurology, reflecting on the 50th Anniversary of the National Institute of Neurological Diseases and Stroke (Bethesda, Md). He outlines his view of "The Coming Interventional Revolution," which will change the practice of neurology by emphasizing prevention, protection of the brain, and promotion of recovery. We are provided a glimpse of the world of neurology in 2025 and beyond, as he sees it!

Fukumoto et al provide interesting new data showing increased β-secretase (BACE) activity and protein in patients with late-onset sporadic Alzheimer disease (AD) compared with controls. Increased total amyloid burden in AD may be in part due to increased BACE activity and supports the need to develop BACE inhibitors that may slow the progression of disease. These data explain further the molecular basis of dementia in AD and provide new evidence for BACE inhibitors as a potential new therapeutic intervention. Roger N. Rosenberg, MD, provides editorial comment.

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