Customize your JAMA Network experience by selecting one or more topics from the list below.
Kleine-Levin syndrome is a rare, sporadic disorder, with discrete spells of hypersomnolence occurring during adolescence, variously accompanied by megaphagia, behavioral changes, psychosis, and mild autonomic symptoms. Familial cases have not previously been reported. We describe 2 siblings who shared uncharacteristically prolonged episodes of hypersomnolence, and the HLA-DR2 haplotype. In one patient, levels of cerebrospinal fluid orexin (hypocretin) during an attack were normal. The presence of an increased sleep drive, despite the occurrence of large amounts of ostensibly restorative sleep, suggests the possible existence of a disorder of sleep satiety.
Katz JD, Ropper AH. Familial Kleine-Levin Syndrome: Two Siblings With Unusually Long Hypersomnic Spells. Arch Neurol. 2002;59(12):1959–1961. doi:10.1001/archneur.59.12.1959
Create a personal account or sign in to: