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This Month in Archives of Neurology
July 2004

This Month in Archives of Neurology

Arch Neurol. 2004;61(7):1004-1005. doi:10.1001/archneur.61.7.1004

In this basic science review, Kabbaj describes what is known about the circuitry of the hypothalamus, midbrain, amygdala, prefrontal cortex, hippocampus, and limbic areas that determines how an individual will perceive stress and cope with it. Are differences among individual responses genetic, conditioned, or both?

The frequent occurrence of the IgG antibody to ganglioside GQ1b in Miller Fisher syndrome and related anti-GQ1b–positive syndromes is of great diagnostic and therapeutic significance to physicians. The pathophysiologic role and clinical relevance of these ganglioside antibodies are elegantly reviewed by Paparounas.

In this review on conscious awareness, Ortinski and Meador address 3 general questions: Where in the brain does consciousness occur? When does it occur in relation to external and/or internal stimuli? How are the underlying neural mechanisms involved in the emergence of consciousness? The integration of several essential nodes of consciousness into 1 seamless hologram of thought and awareness—the binding problem—poses many new questions. The neuronal correlates of consciousness introduced by Crick and Koch are advanced. It is a timely and stimulating discussion of perhaps the central issue in neuroscience: why we are aware.