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Sympathomimetic-induced metabolic derangements within the central nervous system can result in conspicuous changes in neurological functioning and corresponding radiographic abnormalities that can be reversible.
To describe a patient with a “kaleidoscopic” visual illusion who was found by magnetic resonance imaging to have a transient lesion in the splenium of the corpus callosum.
The University of Texas Southwestern Medical Center, Dallas.
A 17-year-old adolescent girl who developed an episode of kaleidoscopic vision while using sympathomimetic-containing diet pills that was associated with a reversible lesion of the splenium of the corpus callosum. Her brother has a history of migraine and experienced a similar episode while using illicit stimulant agents.
Withdrawal of the medication resulted in the cessation of the episodes and normalization of the magnetic resonance image.
Main Outcome Measures
Clinical and radiographic improvement.
Sympathomimetic-induced metabolic derangements can be associated with reversible lesions within the brain.
We hypothesize that the visual fragmentation was a manifestation of a migraine triggered by sympathomimetic-containing diet pills, and that the transient lesion in the corpus callosum was a manifestation of a reversible metabolic derangement. Both the visual fragmentation and the lesion in the corpus callosum resolved once the patient stopped receiving diet pills.
Winslow H, Mickey B, Frohman EM. Sympathomimetic-Induced Kaleidoscopic Visual Illusion Associated With a Reversible Splenium Lesion. Arch Neurol. 2006;63(1):135–137. doi:https://doi.org/10.1001/archneur.63.1.135
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