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Nutt and colleagues determined whether methylphenidate, an inhibitor of the dopamine transporter, would augment the effects of oral levodopa in patients with Parkinson disease in a double-blind, randomized, placebo-controlled, crossover trial. They report that the effects of 0.4 mg/kg of methylphenidate 3 times per day on the motor response to levodopa were small and variable and judged to be clinically insignificant.
Gurnett and Hedera review advances in the rapidly expanding field of epilepsy genetics. They indicate that the majority of genes associated with epilepsy syndromes to date are ion channel genes. There are more than 3000 genes that are expressed at the synapse as well as many other genes expressed nearby in supporting cells and glia that can likewise regulate excitability. The authors review the new novel epilepsy genes and discuss other genetic etiologies, such as chromosomal copy number alterations and gene regulation.
This Month in Archives of Neurology. Arch Neurol. 2007;64(3):310–312. doi:https://doi.org/10.1001/archneur.64.3.310
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