The Archives of Neurology will publish a special theme issue on Genetics and Genomics of Neuroscience and Clinical Neurology and we invite authors to submit manuscripts reporting the results of original research, especially clinical trials. We are particularly interested in the clinical and molecular genetics of neurologic diseases including mechanisms of disease, prenatal tests, genetic testing to detect presymptomatic carriers, pharmacogenomics, gene therapy, genetic counseling, and ethical issues. Papers submitted by October 1, 2007, have the best opportunity to be considered for this theme issue.