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This Month in Archives of Neurology
September 2007

This Month in Archives of Neurology

Arch Neurol. 2007;64(9):1231-1232. doi:10.1001/archneur.64.9.1231

Rodino-Klapac and colleagues are leaders in gene therapy for Duchenne muscular dystrophy (DMD), and their review indicates that this approach has promise for treating DMD. They conducted the very first viral-mediated gene transfer for any muscle disease at Columbus Children's Research Institute and the Ohio State University for limb girdle muscular dystrophy type 2D. They are now conducting the first viral-mediated trial of gene transfer for DMD. Thus, they are in a prime position to tell us of the challenges and potential problems as the field advances this treatment modality to clinical reality.

Levy emphasizes that age influences the clinical progression of Parkinson disease (PD). Advancing age is associated with faster rate of motor progression, decreased levodopa responsiveness, more severe gait and postural impairment, more severe cognitive impairment, and the development of dementia in patients with PD. A model for the relation of PD with aging is proposed.

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