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To facilitate understanding of a group of disorders collectively known as TDP-43 proteinopathies, Neumann and colleagues review advances made since it was shown that TAR-DNA binding protein 43 (TDP-43) is the major disease protein that links frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without motor neuron disease to amyotrophic lateral sclerosis. It is an important new insight into the molecular basis of these disorders and offers new insights into disease causation.
Fins et al propose 2 models characterizing minimal conscious state (MCS) epidemiology. A severity model integrates diagnostic and severity of injury codes and a venue model that tracks patient migration after hospital discharge. The epidemiology of MCS is reviewed.
This Month in Archives of Neurology. Arch Neurol. 2007;64(10):1383–1384. doi:https://doi.org/10.1001/archneur.64.10.1383
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