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February 2019 - July 1959

Decade

Year

Issue

March 2019, Vol 76, No. 3, Pages 243-373

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2019;76(3):243. doi:10.1001/jamaneurol.2018.2976
Viewpoint

Dexamethasone—Friend or Foe for Patients With Glioblastoma?

Abstract Full Text
JAMA Neurol. 2019;76(3):247-248. doi:10.1001/jamaneurol.2018.4530

This Viewpoint discusses the benefits and drawbacks to a dexamethasone regimen for the treatment of individuals with glioblastoma.

On the Brain

Early Awareness of Alzheimer Disease: A Neurologist’s Personal Perspective

Abstract Full Text
JAMA Neurol. 2019;76(3):249. doi:10.1001/jamaneurol.2018.4910

This essay describes the author’s experience with early-stage Alzheimer disease.

Editorial

Potential Benefits of Migraine—What Is It Good For?

Abstract Full Text
has audio
JAMA Neurol. 2019;76(3):250-251. doi:10.1001/jamaneurol.2018.3442

Biomarkers for Alzheimer Dementia in Diverse Racial and Ethnic Minorities—A Public Health Priority

Abstract Full Text
JAMA Neurol. 2019;76(3):251-253. doi:10.1001/jamaneurol.2018.3444

Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(3):254-256. doi:10.1001/jamaneurol.2018.4932
Original Investigation

Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study

Abstract Full Text
has active quiz has audio
JAMA Neurol. 2019;76(3):257-263. doi:10.1001/jamaneurol.2018.3960

This longitudinal analysis of a French national cohort evaluates the association of migraine and type 2 diabetes in women, including changes in the prevalence of active migraine episodes before and after type 2 diabetes diagnosis.

Assessment of Racial Disparities in Biomarkers for Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2019;76(3):264-273. doi:10.1001/jamaneurol.2018.4249

This cohort study examines whether there are disparities between African American and white individuals in molecular biomarkers for Alzheimer disease.

Association of Rituximab Treatment With Disability Progression Among Patients With Secondary Progressive Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(3):274-281. doi:10.1001/jamaneurol.2018.4239

This cohort study uses propensity score–matching analyses to examine disability progression in matched pairs of patients with secondary progressive multiple sclerosis who were treated with rituximab vs those who were never treated with rituximab.

Procedural Clinical Complications, Case-Fatality Risks, and Risk Factors in Endovascular and Neurosurgical Treatment of Unruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2019;76(3):282-293. doi:10.1001/jamaneurol.2018.4165

This systematic review and meta-analysis assesses the rates of procedural complications and fatalities within the 30 days after endovascular or neurosurgical treatment for unruptured intracranial aneurysms.

Risk of Depression and Anxiety in Adults With Cerebral Palsy

Abstract Full Text
open access
JAMA Neurol. 2019;76(3):294-300. doi:10.1001/jamaneurol.2018.4147

This cohort study assesses depression and anxiety in adults with cerebral palsy compared with age-, sex-, and practice-matched adults with cerebral palsy.

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(3):301-309. doi:10.1001/jamaneurol.2018.4053

This study evaluates the clinical, radiologic,al and prognostic features of of myelin oligodendrocyte glycoprotein autoantibody myelitis and compares with myelitis with aquaporin-4–IgG and multiple sclerosis.

Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

Abstract Full Text
open access
JAMA Neurol. 2019;76(3):310-317. doi:10.1001/jamaneurol.2018.3692

This case study investigates the association of regional in vivo retention of the tau positron emission tomography ligand [18F]flortaucipir with the density of tau neuropathology in the corresponding brain regions in a patient with early-onset Alzheimer disease caused by a PSEN1 mutation.

Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

Abstract Full Text
JAMA Neurol. 2019;76(3):318-325. doi:10.1001/jamaneurol.2018.3746

This case-control study investigates cerebrospinal fluid levels of neurofilament light protein in participants with various forms of dementia, motor neuron disease, and movement disorders and controls, as determined by clinical and autopsy-definite criteria.

Diagnostic Errors in Initial Misdiagnosis of Optic Nerve Sheath Meningiomas

Abstract Full Text
JAMA Neurol. 2019;76(3):326-332. doi:10.1001/jamaneurol.2018.3989

This medical record review identifies factors and diagnostic errors that contribute to the initial misdiagnosis of optic nerve sheath meningiomas.

Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic Encephalopathy

Abstract Full Text
JAMA Neurol. 2019;76(3):333-341. doi:10.1001/jamaneurol.2018.4182

This validation study assesses the ability of a panel of umbilical cord microRNA to evaluate the development and severity of encephalopathy in infants following perinatal asphyxia.

Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy

Abstract Full Text
JAMA Neurol. 2019;76(3):342-350. doi:10.1001/jamaneurol.2018.2941

This study uses exome sequencing and genetic evaluation to explain the shared condition of 4 children from 2 unrelated families who were affected by refractory epileptic seizures, respiratory failure, brain abnormalities, and death in the neonatal period.

Brief Report

Dancing Dorsal Quadrilaterals: A Novel Peripherally Induced Movement Disorder

Abstract Full Text
has multimedia
JAMA Neurol. 2019;76(3):351-354. doi:10.1001/jamaneurol.2018.3948

This study introduces and characterizes the dancing dorsal quadrilaterals syndrome, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation.

Review

Current Understanding and Gaps in Research of Carotid Webs in Ischemic Strokes: A Review

Abstract Full Text
JAMA Neurol. 2019;76(3):355-361. doi:10.1001/jamaneurol.2018.3366

This narrative review addresses the current understanding of carotid webs as a modifiable risk factor for stroke.

Images in Neurology

Seesaw-Pattern Ocular Bobbing in a Patient With Pontine Bleed

Abstract Full Text
has multimedia
JAMA Neurol. 2019;76(3):362-363. doi:10.1001/jamaneurol.2018.3853

This case report describes seesaw-pattern ocular bobbing in a patient with pontine bleed.

Orbital Apex Syndrome in a Patient With Histiocytic Sarcoma

Abstract Full Text
JAMA Neurol. 2019;76(3):364-365. doi:10.1001/jamaneurol.2018.3333

This case report describes orbital apex syndrome in a young man with histiocytic sarcoma.

JAMA Neurology Clinical Challenge

Type 2 Diabetes Presenting With Persistent Chorea

Abstract Full Text
JAMA Neurol. 2019;76(3):366-367. doi:10.1001/jamaneurol.2018.4089

A man in his late 60s with a diagnosis of type 2 diabetes for more than 10 years that was complicated by neuropathy and retinopathy presents with persistent chorea in the left upper extremity for about 1 month despite aggressive correction with insulin. What is your diagnosis?

Research Letter

Association of Conflicts of Interest for Public Speakers for the Peripheral and Central Nervous System Drugs Advisory Committee of the US Food and Drug Administration With Their Statements

Abstract Full Text
JAMA Neurol. 2019;76(3):368-369. doi:10.1001/jamaneurol.2018.3997

This study uses transcripts from the Peripheral and Central Nervous System Drug Advisory Committee of the US Food and Drug Administration to evaluate the association of conflicts of interest for public speakers at committee meetings with the speakers’ statements.

Comment & Response

Final Coverage Determination for Magnetic Resonance Imaging in Patients With Cardiac Devices

Abstract Full Text
JAMA Neurol. 2019;76(3):369-370. doi:10.1001/jamaneurol.2018.4496

The Importance of Blood Pressure Gradients in the Brain: Cerebral Small Vessel Disease

Abstract Full Text
JAMA Neurol. 2019;76(3):370-371. doi:10.1001/jamaneurol.2018.4627

Clarification of Reporting of Outcome Measures and Protocol Deviations in Report of a Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(3):371-372. doi:10.1001/jamaneurol.2018.3595

Clarification of Reporting of Outcome Measures and Protocol Deviations in Report of a Randomized Clinical Trial—Reply

Abstract Full Text
JAMA Neurol. 2019;76(3):372-373. doi:10.1001/jamaneurol.2018.3598
Correction

Missing Information About Plan for Analyses of Other Outcomes

Abstract Full Text
free access
JAMA Neurol. 2019;76(3):373. doi:10.1001/jamaneurol.2018.4633

Numeric Error in Abstract

Abstract Full Text
free access
JAMA Neurol. 2019;76(3):373. doi:10.1001/jamaneurol.2018.4767
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(3):245. doi:10.1001/jamaneurol.2018.2977
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