[Skip to Navigation]
Sign In

March 2021 - July 1959

Decade

Year

Issue

April 2021, Vol 78, No. 4, Pages 375-497

Viewpoint

Perils of Race-Based Norms in Cognitive Testing: The Case of Former NFL Players

Abstract Full Text
JAMA Neurol. 2021;78(4):377-378. doi:10.1001/jamaneurol.2020.4763

This Viewpoint explains the practice and perils of using race-adjusted norms and proposes a new approach that could replace the current standard in the National Football League.

The Future Is P-Tau—Anticipating Direct-to-Consumer Alzheimer Disease Blood Tests

Abstract Full Text
JAMA Neurol. 2021;78(4):379-380. doi:10.1001/jamaneurol.2020.4835

This Viewpoint describes the benefits and challenges offered by emerging direct-to-consumer tests for Alzheimer disease through measurement of blood levels of phosphorylated tau.

On the Brain

No Visitors Allowed

Abstract Full Text
free access has active quiz
JAMA Neurol. 2021;78(4):381-382. doi:10.1001/jamaneurol.2021.0050

This essay describes the author’s experience of not being able to visit and advocate for her mother in the intensive care unit during the coronavirus disease 2019 pandemic.

Editorial

To Screen or Not to Screen for Carotid Stenosis: Is That the Question?

Abstract Full Text
JAMA Neurol. 2021;78(4):383-384. doi:10.1001/jamaneurol.2020.5382

This editorial discusses the screening for carotid stenosis recommendation statement by the US Preventive Services Task Force.

Original Investigation

Effect of Motor Skill Training in Functional Activities vs Strength and Flexibility Exercise on Function in People With Chronic Low Back Pain: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2021;78(4):385-395. doi:10.1001/jamaneurol.2020.4821

This randomized clinical trial investigates whether an exercise-based treatment of person-specific motor skill training (MST) in performance of functional activities is more effective in improving function than strength and flexibility exercise immediately, 6 months, and 12 months following treatment.

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2021;78(4):396-406. doi:10.1001/jamaneurol.2020.4986

This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to investigate if blood-based biomarkers can be used to monitor the progression of Alzheimer disease neurodegeneration.

Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease

Abstract Full Text
open access
JAMA Neurol. 2021;78(4):407-413. doi:10.1001/jamaneurol.2020.5157

This cohort study investigates whether use of terazosin, doxazosin, and alfuzosin is associated with a decreased risk of developing Parkinson disease compared with use of tamsulosin.

Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2021;78(4):414-425. doi:10.1001/jamaneurol.2020.4920

This cross-sectional study presents a data-driven classification of cognitive functions in patients with multiple sclerosis.

Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis: A Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2021;78(4):426-433. doi:10.1001/jamaneurol.2020.5407

This parallel-group, randomized, single-blind clinical trial compares rapid- with slow-tapering dosing regimens of prednisone in patients with generalized myasthenia gravis who have achieved minimal manifestation status.

Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study

Abstract Full Text
JAMA Neurol. 2021;78(4):434-444. doi:10.1001/jamaneurol.2021.0001

This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion.

Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials

Abstract Full Text
open access
JAMA Neurol. 2021;78(4):445-453. doi:10.1001/jamaneurol.2020.5505

This study evaluates the association between flortaucipir positron emission tomography visual interpretation and patients’ near-term clinical progression of mild cognitive impairment and dementia owing to Alzheimer disease.

Seizure Cycles in Focal Epilepsy

Abstract Full Text
has active quiz
JAMA Neurol. 2021;78(4):454-463. doi:10.1001/jamaneurol.2020.5370

This cohort study uses data from continous intracranial electroencephalography and seizure diaries to investigate the prevalence, strength, and temporal patterns of seizure cycles over timescales of hours to years.

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets

Abstract Full Text
open access
JAMA Neurol. 2021;78(4):464-472. doi:10.1001/jamaneurol.2020.5257

This genetic association study investigates what genes and genomic processes underlie the risk of sporadic Parkinson disease.

Brief Report

Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era

Abstract Full Text
has audio
JAMA Neurol. 2021;78(4):473-477. doi:10.1001/jamaneurol.2020.5011

This study examines the association between Agent Orange exposure and incident dementia diagnosis among US veterans who served in the Vietnam era.

Long-term Socioeconomic Outcomes Associated With Pediatric-Onset Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2021;78(4):478-482. doi:10.1001/jamaneurol.2020.5520

This cohort study evaluates the association between pediatric-onset multiple sclerosis and education and income throughout adulthood.

Review

Adolescent-Onset and Adult-Onset Vitamin-Responsive Neurogenetic Diseases: A Review

Abstract Full Text
JAMA Neurol. 2021;78(4):483-490. doi:10.1001/jamaneurol.2020.4911

This narrative review describes adolescent-onset and adult-onset vitamin-responsive neurogenetic diseases, their underlying biology, and their treatments.

Images in Neurology

Cortical Vein Thrombosis, Tortuous Venous Vasculature, and Microhemorrhages in Neurosarcoidosis

Abstract Full Text
JAMA Neurol. 2021;78(4):491-492. doi:10.1001/jamaneurol.2020.5440

This case report describes a 13-year-old boy who presented with an episode of left-sided facial droop and dysarthria lasting 90 minutes.

Bilateral Vagus Nerve Enhancement in a Patient With Leptomeningeal Lymphoplasmacytic Lymphoma Presenting with Intractable Hiccups

Abstract Full Text
JAMA Neurol. 2021;78(4):493-494. doi:10.1001/jamaneurol.2020.4830

This case report describes a 73-year-old man who presented with intractable hiccups and lymphoplasmacytic lymphoma.

Comment & Response

Living to Dream

Abstract Full Text
JAMA Neurol. 2021;78(4):495. doi:10.1001/jamaneurol.2021.0053

Living to Dream—Reply

Abstract Full Text
JAMA Neurol. 2021;78(4):495-496. doi:10.1001/jamaneurol.2021.0056

Risk of Hemorrhagic Stroke in Patients With Coronavirus Disease 2019

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):496-497. doi:10.1001/jamaneurol.2021.0117

Risk of Hemorrhagic Stroke in Patients With Coronavirus Disease 2019—Reply

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):497. doi:10.1001/jamaneurol.2021.0120
Correction

Error in Figure and Table

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):497. doi:10.1001/jamaneurol.2020.5321

Error in Author Name and Change to Open Access

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):497. doi:10.1001/jamaneurol.2021.0103

Errors in Figure

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):497. doi:10.1001/jamaneurol.2021.0352
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2021;78(4):375. doi:10.1001/jamaneurol.2020.3655
×