April 2021, Vol 78, No. 4, Pages 375-497

This randomized clinical trial investigates whether an exercise-based treatment of person-specific motor skill training (MST) in performance of functional activities is more effective in improving function than strength and flexibility exercise immediately, 6 months, and 12 months following treatment.

This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to investigate if blood-based biomarkers can be used to monitor the progression of Alzheimer disease neurodegeneration.

This cohort study investigates whether use of terazosin, doxazosin, and alfuzosin is associated with a decreased risk of developing Parkinson disease compared with use of tamsulosin.

This cross-sectional study presents a data-driven classification of cognitive functions in patients with multiple sclerosis.

This parallel-group, randomized, single-blind clinical trial compares rapid- with slow-tapering dosing regimens of prednisone in patients with generalized myasthenia gravis who have achieved minimal manifestation status.

This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion.

This study evaluates the association between flortaucipir positron emission tomography visual interpretation and patients’ near-term clinical progression of mild cognitive impairment and dementia owing to Alzheimer disease.

This cohort study uses data from continous intracranial electroencephalography and seizure diaries to investigate the prevalence, strength, and temporal patterns of seizure cycles over timescales of hours to years.

This genetic association study investigates what genes and genomic processes underlie the risk of sporadic Parkinson disease.