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December 2020 - July 1959




January 2021, Vol 78, No. 1, Pages 3-120


Reforming the Process for Deep Brain Stimulation and Neurologic Device Approval in Rare Diseases

Abstract Full Text
JAMA Neurol. 2021;78(1):5-6. doi:10.1001/jamaneurol.2020.4232

This Viewpoint posits that the regnant approval process for the use of neurotechnological devices to treat rare diseases is in need of reform.

On the Brain

What Caring for My Aging Parents Taught Me That Medical Education Did Not

Abstract Full Text
JAMA Neurol. 2021;78(1):7-8. doi:10.1001/jamaneurol.2020.4454

This essay describes the author’s experience caring for his elderly parents and offers tips to others who are or will be caring for their parents as they age.


Cerebral Microbleeds and Antithrombotic Treatments—Stop Worrying About Bleeding

Abstract Full Text
JAMA Neurol. 2021;78(1):9-10. doi:10.1001/jamaneurol.2020.3847
Original Investigation

Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2021;78(1):11-20. doi:10.1001/jamaneurol.2020.3836

This prespecified analysis of a randomized clinical trial investigates the effect of cerebral microbleeds on patients with embolic stroke of undetermined source taking either daily rivaroxaban or aspirin.

Endovascular Treatment After Stroke Due to Large Vessel Occlusion for Patients Presenting Very Late From Time Last Known Well

Abstract Full Text
JAMA Neurol. 2021;78(1):21-29. doi:10.1001/jamaneurol.2020.2804

This case-control study examines the prevalence of salvageable tissues 16 hours or more from the time the patient was last known well after ischemic stroke due to emergent large vessel occlusion and investigates the effectiveness of endovascular treatment in delayed large vessel occlusion.

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Abstract Full Text
open access
JAMA Neurol. 2021;78(1):30-40. doi:10.1001/jamaneurol.2020.3311

This diagnostic study investigates sensitive and specific skin biomarkers for antemortem diagnosis of Parkinson disease and other synucleinopathies.

Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients

Abstract Full Text
JAMA Neurol. 2021;78(1):41-47. doi:10.1001/jamaneurol.2020.3263

This cohort study describes the outcomes of assessments of brain injury in patients with critical illness in intensive care units using a portable low-field magnetic resonance image device at the bedside, rather than a conventional imaging suite.

Efficacy and Safety of 2 Fingolimod Doses vs Glatiramer Acetate for the Treatment of Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial

Abstract Full Text
open access has active quiz
JAMA Neurol. 2021;78(1):48-60. doi:10.1001/jamaneurol.2020.2950

This randomized clinical trial evaluates the efficacy and safety of fingolimod, 0.5 mg, and fingolimod, 0.25 mg, compared with glatiramer acetate, 20 mg, and examines whether these fingolimod doses show superior efficacy to glatiramer acetate for the treatment of adult patients with relapsing-remitting multiple sclerosis.

Association of Selective Serotonin Reuptake Inhibitor Use After Intracerebral Hemorrhage With Hemorrhage Recurrence and Depression Severity

Abstract Full Text
JAMA Neurol. 2021;78(1):61-67. doi:10.1001/jamaneurol.2020.3142

This study determines whether selective serotonin reuptake inhibitor use among survivors of primary intracerebral hemorrhage was associated with intracerebral hemorrhage recurrence and decreased severity of depressive symptoms.

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2021;78(1):68-76. doi:10.1001/jamaneurol.2020.2590

This randomized clinical trial examines which medication (pregabalin, duloxetine, nortriptyline, or mexiletine) is most effective for reducing neuropathic pain and best tolerated in patients with cryptogenic sensory polyneuropathy.

A 5-Decade Analysis of Incidence Trends of Ischemic Stroke After Transient Ischemic Attack: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2021;78(1):77-87. doi:10.1001/jamaneurol.2020.3627

This systematic review and meta-analysis calculates the pooled event rate for ischemic stroke within 2, 7, 30, and 90 days of a transient ischemic attack and compares this incidence among patients recruited before 1999, from 1999 to 2007, and after 2007.

Assessment of Emergency Department and Inpatient Use and Costs in Adult and Pediatric Functional Neurological Disorders

Abstract Full Text
has audio
JAMA Neurol. 2021;78(1):88-101. doi:10.1001/jamaneurol.2020.3753

This economic evaluation assesses US emergency department and inpatient use and charges for functional neurological disorders.

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

Abstract Full Text
JAMA Neurol. 2021;78(1):102-113. doi:10.1001/jamaneurol.2020.3536

This genome-wide association study identifies additional Alzheimer disease risk loci in African American individuals using the African Genome Resource panel.

Images in Neurology

Ultrasonography Evaluation of Bilateral Focal Auricular Dyskinesia

Abstract Full Text
has multimedia
JAMA Neurol. 2021;78(1):114. doi:10.1001/jamaneurol.2020.3352

This case report describes a woman in her late 20s with a 1-week history of almost continuous bilateral ear twitching.

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy With the Detection of Anti-GM3 and Anti-GM4 IgG Antibodies, Masquerading as Brown-Sequared Syndrome

Abstract Full Text
JAMA Neurol. 2021;78(1):115-116. doi:10.1001/jamaneurol.2020.3828

This article describes a woman with a disease that was initially diagnosed as Brown-Sequared syndrome but later shown to be glial fibrillary acidic protein astrocytopathy involving anti-GM3 and anti-GM4 IgG antibodies.

Research Letter

Disparities Across Sexual Orientation in Migraine Among US Adults

Abstract Full Text
JAMA Neurol. 2021;78(1):117-118. doi:10.1001/jamaneurol.2020.3406

This cohort study examines the association of migraine with sexual orientation in a sample of US adults.

Biotinidase Deficiency as a Mimic of Neuromyelitis Optica Spectrum Disorder in Childhood

Abstract Full Text
JAMA Neurol. 2021;78(1):118-120. doi:10.1001/jamaneurol.2020.3558

This study details a case of biotinidase deficiency mimicking neuromyelitis optica spectrum disorders and reviews prior cases of biotinidase deficiency that met Wingerchuck 2015 criteria for neuromyelitis optica spectrum disorder.


Correction to Author’s Academic Degrees

Abstract Full Text
free access
JAMA Neurol. 2021;78(1):120. doi:10.1001/jamaneurol.2020.4087

Errors in Table 2 and Table 3

Abstract Full Text
free access
JAMA Neurol. 2021;78(1):120. doi:10.1001/jamaneurol.2020.4567

Error in P Value in Abstract and Results

Abstract Full Text
free access
JAMA Neurol. 2021;78(1):120. doi:10.1001/jamaneurol.2020.4698

Error in Data in Abstract

Abstract Full Text
free access
JAMA Neurol. 2021;78(1):120. doi:10.1001/jamaneurol.2020.4582
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2021;78(1):3. doi:10.1001/jamaneurol.2020.3637