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June 2018 - July 1959

Decade

Year

Issue

July 2018, Vol 75, No. 7, Pages 773-897

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2018;75(7):773. doi:10.1001/jamaneurol.2017.2646
Viewpoint

No Evident Disease Activity—More Than a Risky Ambition?

Abstract Full Text
JAMA Neurol. 2018;75(7):781-782. doi:10.1001/jamaneurol.2018.0829

This Viewpoint discusses the validity of using a strategy of targeting no evident disease activity to treat relapsing multiple sclerosis.

Cluster Headache Is in Part a Disorder of the Circadian System

Abstract Full Text
JAMA Neurol. 2018;75(7):783-784. doi:10.1001/jamaneurol.2018.1049

This Viewpoint explicates the importance of the circadian system to cluster headaches and proposes this system as a target for drug treatment.

On the Brain

Til Neglect Do Us Part

Abstract Full Text
JAMA Neurol. 2018;75(7):785-786. doi:10.1001/jamaneurol.2018.1185

This essay discusses a husband and wife’s recovery from hemineglect.

Editorial

Arterial Partial Pressure of Carbon Dioxide and Secondary Brain Injury—6 Degrees of Separation?

Abstract Full Text
JAMA Neurol. 2018;75(7):787-788. doi:10.1001/jamaneurol.2018.0003

Progressive Multifocal Leukoencephalopathy Lesions and JC VirusThe Limits and Value of Imaging

Abstract Full Text
JAMA Neurol. 2018;75(7):789-790. doi:10.1001/jamaneurol.2018.0004

Gene Therapy in Alzheimer Disease—It May Be Feasible, but Will It Be Beneficial?

Abstract Full Text
JAMA Neurol. 2018;75(7):791-793. doi:10.1001/jamaneurol.2017.4029

Avoidance of Severe Cutaneous Adverse Drug Events as a First Step in Precision Neurology

Abstract Full Text
JAMA Neurol. 2018;75(7):793-795. doi:10.1001/jamaneurol.2018.0001
Original Investigation

Association of Sickle Cell Trait With Ischemic Stroke Among African AmericansA Meta-analysis

Abstract Full Text
has active quiz has audio
JAMA Neurol. 2018;75(7):802-807. doi:10.1001/jamaneurol.2018.0571

This meta-analysis examines whether sickle cell trait is associated with a higher risk of incident ischemic stroke among African Americans.

Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal PainA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2018;75(7):808-817. doi:10.1001/jamaneurol.2018.0492

This randomized clinical trial compares pain neuroscience education combined with cognition-targeted motor control training with current best-evidence physiotherapy for reducing pain and improving functionality, gray matter morphologic features, and pain cognitions in individuals with chronic spinal pain.

Association of Hypercapnia and Hypercapnic Acidosis With Clinical Outcomes in Mechanically Ventilated Patients With Cerebral Injury

Abstract Full Text
JAMA Neurol. 2018;75(7):818-826. doi:10.1001/jamaneurol.2018.0123

This cross-sectional study reviews the association of compensated hypercapnia and hypercapnic acidosis during the first 24 hours of intensive care unit admission on hospital mortality in adult mechanically ventilated patients with cerebral injury.

Association of Progressive Multifocal Leukoencephalopathy Lesion Volume With JC Virus Polymerase Chain Reaction Results in Cerebrospinal Fluid of Natalizumab-Treated Patients With Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2018;75(7):827-833. doi:10.1001/jamaneurol.2018.0094

This study investigates the association of progressive multifocal leukoencephalopathy lesion characteristics on magnetic resonance imaging with both qualitative and quantitative John Cunningham virus polymerase chain reaction results in cerebrospinal fluid of patients with natalizumab-associated progressive multifocal leukoencephalopathy.

Adeno-Associated Viral Vector (Serotype 2)–Nerve Growth Factor for Patients With Alzheimer DiseaseA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2018;75(7):834-841. doi:10.1001/jamaneurol.2018.0233

This randomized clinical trial determine whether stereotactically-guided intracerebral injections of adeno-associated viral vector (serotype 2)-nerve growth factor are well tolerated and exhibit preliminary evidence of impact on cognitive decline in patients with mild to moderate Alzheimer disease with dementia.

Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population

Abstract Full Text
has active quiz
JAMA Neurol. 2018;75(7):842-849. doi:10.1001/jamaneurol.2018.0278

This cohort study evaluates the use of preemptive human leukocyte antigen allele HLA-A*31:01 genetic screening to reduce carbamazepine-induced cutaneous adverse drug reactions in a Japanese population.

Cerebral Microbleeds and the Effect of Intensive Blood Pressure Reduction on Hematoma Expansion and Functional OutcomesA Secondary Analysis of the ATACH-2 Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2018;75(7):850-859. doi:10.1001/jamaneurol.2018.0454

This predefined subgroup analysis of a randomized clinical trial characterizes cerebral microbleeds in acute intracerebral hemorrhage and assesses the potential for interaction between underlying small vessel disease and assignment to acute intensive blood pressure targeting for functional outcomes and hematoma expansion.

Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum

Abstract Full Text
JAMA Neurol. 2018;75(7):860-875. doi:10.1001/jamaneurol.2018.0372

This genome-wide association study examines whether there are common genetic variants that determine risk for amyotrophic lateral sclerosis and other neurodegenerative diseases and identifies novel shared genetic variants and their functional pathways.

Brief Report

Using Smartphones and Machine Learning to Quantify Parkinson Disease SeverityThe Mobile Parkinson Disease Score

Abstract Full Text
JAMA Neurol. 2018;75(7):876-880. doi:10.1001/jamaneurol.2018.0809

This study develops and assesses a smartphone-based measure of Parkinson disease severity, symptom fluctuations, and response to dopaminergic therapy.

Review

The Changing Landscape of Pediatric Migraine TherapyA Review

Abstract Full Text
JAMA Neurol. 2018;75(7):881-887. doi:10.1001/jamaneurol.2018.0046

This review discusses current acute and preventive pharmacologic therapies for the treatment of migraine in the pediatric and adolescent population.

Images in Neurology

Osmotic Demyelination Syndrome With Evolving Movement Disorders

Abstract Full Text
has multimedia
JAMA Neurol. 2018;75(7):888-889. doi:10.1001/jamaneurol.2018.0983

A 41-year-old man was admitted with acute parkinsonism, which deteriorated over the next few days to a state of akinetic mutism.

Research Letter

Publication and Dissemination of Results in Clinical Trials of Neurology

Abstract Full Text
JAMA Neurol. 2018;75(7):890-891. doi:10.1001/jamaneurol.2018.0674

This review of interventional neurology trials registered in ClinicalTrials.gov classifies trials and compares publication rates and time to publication between 2007 and 2014.

Novel Glial Targets and Recurrent Longitudinally Extensive Transverse Myelitis

Abstract Full Text
JAMA Neurol. 2018;75(7):892-895. doi:10.1001/jamaneurol.2018.0805

This cohort study presents serological data with regard to 2 novel glial targets (myelin oligodendrocyte glycoprotein and glial fibrillary acidic protein) in recurrent longitudinally extensive transverse myelitis.

Comment & Response

Additional Factors in Considering Patent Foramen Ovale Closure to Prevent Recurrent Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2018;75(7):895. doi:10.1001/jamaneurol.2018.1019

Additional Factors in Considering Patent Foramen Ovale Closure to Prevent Recurrent Ischemic Stroke—Reply

Abstract Full Text
JAMA Neurol. 2018;75(7):895-896. doi:10.1001/jamaneurol.2018.1022

Association of Optic Pathways and Brain Structure With Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia

Abstract Full Text
JAMA Neurol. 2018;75(7):896. doi:10.1001/jamaneurol.2018.1066

Association of Optic Pathways and Brain Structure With Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia—Reply

Abstract Full Text
JAMA Neurol. 2018;75(7):896-897. doi:10.1001/jamaneurol.2018.1069
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2018;75(7):776. doi:10.1001/jamaneurol.2017.2647
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