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December 2018 - July 1959

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Issue

January 2019, Vol 76, No. 1, Pages 3-117

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2019;76(1):3. doi:10.1001/jamaneurol.2018.2966
Viewpoint

Familial Trigeminal Neuralgia Cases Implicate Genetic Factors in Disease Pathogenesis

Abstract Full Text
JAMA Neurol. 2019;76(1):9-10. doi:10.1001/jamaneurol.2018.3322

This Viewpoint discusses genetic models of trigeminal neuralgia pathogenesis.

On the Brain

Learning to Surf

Abstract Full Text
JAMA Neurol. 2019;76(1):11-12. doi:10.1001/jamaneurol.2018.3650

This personal narrative examines the sudden end of an ill spouse’s medical career through the metaphor of a surfing mishap.

Editorial

A Promising Skills-Based Intervention to Reduce Blood Pressure in Individuals With Stroke and Transient Ischemic Attack

Abstract Full Text
JAMA Neurol. 2019;76(1):13-14. doi:10.1001/jamaneurol.2018.2935

Early-Phase Randomized Clinical Trials—Expectations vs Hard Reality

Abstract Full Text
JAMA Neurol. 2019;76(1):15-16. doi:10.1001/jamaneurol.2018.3301

Challenges in Defining Inappropriate Medication Use in Parkinson Disease Dementia

Abstract Full Text
JAMA Neurol. 2019;76(1):17-19. doi:10.1001/jamaneurol.2018.2826
Original Investigation

Efficacy of a Discharge Educational Strategy vs Standard Discharge Care on Reduction of Vascular Risk in Patients With Stroke and Transient Ischemic Attack: The DESERVE Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(1):20-27. doi:10.1001/jamaneurol.2018.2926

This randomized clinical trial determines the efficacy of a culturally tailored skills-based educational intervention with telephone follow-up compared with standard discharge care on systolic blood pressure reduction in a multiethnic cohort of patients with mild/moderate stroke/transient ischemic attack.

Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(1):28-34. doi:10.1001/jamaneurol.2018.3077

This randomized clinical trial assesses the effect of gabapentin vs pregabalin in leg pain intensity and compares adverse events among adults with chronic sciatica.

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(1):35-40. doi:10.1001/jamaneurol.2018.3288

This randomized clinical trial examines the safety, tolerability, and feasibility of young plasma infusion in patients with mild to moderate Alzheimer disease dementia in the Plasma for Alzheimer Symptom Amelioration study.

Patterns of Dementia Treatment and Frank Prescribing Errors in Older Adults With Parkinson Disease

Abstract Full Text
JAMA Neurol. 2019;76(1):41-49. doi:10.1001/jamaneurol.2018.2820

This cross-sectional study analyzes data from the Centers for Medicare & Medicaid Services to identify both effective and ineffective dementia medication prescribing patterns as well as patient characteristics and comorbid conditions associated with dementia treatment among older Medicare beneficiaries with Parkinson disease.

Association of Unintended Pregnancy With Spontaneous Fetal Loss in Women With Epilepsy: Findings of the Epilepsy Birth Control Registry

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(1):50-55. doi:10.1001/jamaneurol.2018.3089

This study assesses whether unplanned pregnancy is associated with spontaneous fetal loss in women with epilepsy.

Characteristics of Spontaneous Spinal Cord Infarction and Proposed Diagnostic Criteria

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(1):56-63. doi:10.1001/jamaneurol.2018.2734

This observational study describes the characteristics of spontaneous spinal cord infarction and proposes diagnostic criteria.

Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest

Abstract Full Text
JAMA Neurol. 2019;76(1):64-71. doi:10.1001/jamaneurol.2018.3223

This analysis of biobank data compares the sensitivity and specificity of neurofilament light chain levels vs other biomarkers and examination methods in patients after cardiac arrest.

Mapping the Supratentorial Cerebral Arterial Territories Using 1160 Large Artery Infarcts

Abstract Full Text
JAMA Neurol. 2019;76(1):72-80. doi:10.1001/jamaneurol.2018.2808

This cross-sectional study maps out the variable anatomy of the anterior, middle, and posterior cerebral artery to improve the state of knowledge on the supratentorial vascular supply to the brain.

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2019;76(1):81-94. doi:10.1001/jamaneurol.2018.3122

This systematic review and meta-analysis investigates the clinical and therapeutic significance of magnetic resonance imaging markers of covert vascular brain injury (white matter hyperintensities, brain infarcts, and cerebral microbleeds) associated with stroke, dementia, and death in community-dwelling older adults.

Brief Report

Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration

Abstract Full Text
open access
JAMA Neurol. 2019;76(1):95-100. doi:10.1001/jamaneurol.2018.3057

This case-control study combines portions of 2 existing cohorts to investigate medial temporal lobe structure, white matter lesion load, and β-amyloid deposition in older women who underwent bilateral salpingo-oophorectomy before age 50 years and before reaching natural menopause, compared with a group of female control participants.

Review

Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review

Abstract Full Text
JAMA Neurol. 2019;76(1):101-108. doi:10.1001/jamaneurol.2018.2505

This narrative review describes the evidence for propagation of distinct tau strains in Alzheimer disease and mechanistic insights into cell-to-cell transmission of pathological tau in multiple neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy, corticobasal degeneration, and Pick disease.

Images in Neurology

Compressive Lateral Femoral Cutaneous Neuropathy Secondary to Sartorius Muscle Fibrosis

Abstract Full Text
JAMA Neurol. 2019;76(1):109-110. doi:10.1001/jamaneurol.2018.2955

This case report describes a mononeuropathy of the lateral femoral cutaneous nerve.

Global Orbital Infarction Syndrome After a Carotid Artery Dissection

Abstract Full Text
JAMA Neurol. 2019;76(1):111-112. doi:10.1001/jamaneurol.2018.2880

This case report describes an unusual ophthalmologic emergency after a 59-year-old man experiences an ischemic stroke in the right middle cerebral artery.

Comment & Response

Misinterpretation of Study Data

Abstract Full Text
JAMA Neurol. 2019;76(1):113. doi:10.1001/jamaneurol.2018.3668

Misinterpretation of Study Data—Reply

Abstract Full Text
JAMA Neurol. 2019;76(1):113-114. doi:10.1001/jamaneurol.2018.3671

Overlooked Implications of Disturbed Sleep in Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2019;76(1):114-115. doi:10.1001/jamaneurol.2018.3738

Neuropathology of Circadian Alterations in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2019;76(1):115. doi:10.1001/jamaneurol.2018.3755

Neuropathology of Circadian Alterations in Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2019;76(1):115-116. doi:10.1001/jamaneurol.2018.3758

On Mediation Models in Clinical Neurology Studies

Abstract Full Text
JAMA Neurol. 2019;76(1):116-117. doi:10.1001/jamaneurol.2018.3884

On Mediation Models in Clinical Neurology Studies—Reply

Abstract Full Text
JAMA Neurol. 2019;76(1):117. doi:10.1001/jamaneurol.2018.3887
Correction

Error in Corresponding Author and Affiliation

Abstract Full Text
free access
JAMA Neurol. 2019;76(1):117. doi:10.1001/jamaneurol.2018.3537

Error in Abstract

Abstract Full Text
free access
JAMA Neurol. 2019;76(1):117. doi:10.1001/jamaneurol.2018.3928
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(1):5. doi:10.1001/jamaneurol.2018.2967
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