Hyacinth I. Hyacinth, MD, PhD, MPH; Cara L. Carty, PhD; Samantha R. Seals, PhD; et al.
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JAMA Neurol. 2018;75(7):802-807. doi:10.1001/jamaneurol.2018.0571
This meta-analysis examines whether sickle cell trait is associated with a higher risk of incident ischemic stroke among African Americans.
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Audio Interview:
Association of Sickle Cell Trait With Ischemic Stroke Among African Americans
Anneleen Malfliet, MSc; Jeroen Kregel, PhD; Iris Coppieters, PhD; et al.
JAMA Neurol. 2018;75(7):808-817. doi:10.1001/jamaneurol.2018.0492
This randomized clinical trial compares pain neuroscience education combined with cognition-targeted motor control training with current best-evidence physiotherapy for reducing pain and improving functionality, gray matter morphologic features, and pain cognitions in individuals with chronic spinal pain.
Ravindranath Tiruvoipati, FCICM; David Pilcher, FCICM; John Botha, FCICM; et al.
JAMA Neurol. 2018;75(7):818-826. doi:10.1001/jamaneurol.2018.0123
This cross-sectional study reviews the association of compensated hypercapnia and hypercapnic acidosis during the first 24 hours of intensive care unit admission on hospital mortality in adult mechanically ventilated patients with cerebral injury.
Martijn T. Wijburg, MD; Iris Kleerekooper, MD; Birgit I. Lissenberg-Witte, PhD; et al.
JAMA Neurol. 2018;75(7):827-833. doi:10.1001/jamaneurol.2018.0094
This study investigates the association of progressive multifocal leukoencephalopathy lesion characteristics on magnetic resonance imaging with both qualitative and quantitative John Cunningham virus polymerase chain reaction results in cerebrospinal fluid of patients with natalizumab-associated progressive multifocal leukoencephalopathy.
Michael S. Rafii, MD, PhD; Mark H. Tuszynski, MD, PhD; Ronald G. Thomas, PhD; et al.
JAMA Neurol. 2018;75(7):834-841. doi:10.1001/jamaneurol.2018.0233
This randomized clinical trial determine whether stereotactically-guided intracerebral injections of adeno-associated viral vector (serotype 2)-nerve growth factor are well tolerated and exhibit preliminary evidence of impact on cognitive decline in patients with mild to moderate Alzheimer disease with dementia.
Taisei Mushiroda, PhD; Yukitoshi Takahashi, MD, PhD; Teiichi Onuma, MD, PhD; et al.
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JAMA Neurol. 2018;75(7):842-849. doi:10.1001/jamaneurol.2018.0278
This cohort study evaluates the use of preemptive human leukocyte antigen allele HLA-A*31:01 genetic screening to reduce carbamazepine-induced cutaneous adverse drug reactions in a Japanese population.
Ashkan Shoamanesh, MD; Andrea Morotti, MD; Javier M. Romero, MD; et al.
JAMA Neurol. 2018;75(7):850-859. doi:10.1001/jamaneurol.2018.0454
This predefined subgroup analysis of a randomized clinical trial characterizes cerebral microbleeds in acute intracerebral hemorrhage and assesses the potential for interaction between underlying small vessel disease and assignment to acute intensive blood pressure targeting for functional outcomes and hematoma expansion.
Celeste M. Karch, PhD; Natalie Wen; Chun C. Fan, MD; et al.
JAMA Neurol. 2018;75(7):860-875. doi:10.1001/jamaneurol.2018.0372
This genome-wide association study examines whether there are common genetic variants that determine risk for amyotrophic lateral sclerosis and other neurodegenerative diseases and identifies novel shared genetic variants and their functional pathways.