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February 2020 - July 1959

Decade

Year

Issue

March 2020, Vol 77, No. 3, Pages 286-394

Viewpoint

Freezing of Gait and Its Levodopa Paradox

Abstract Full Text
JAMA Neurol. 2020;77(3):287-288. doi:10.1001/jamaneurol.2019.4006

This Viewpoint describes freezing of gait in Parkinson disease, its association with long-term levodopa use, underlying pathophysiology, and options for improvements to clinical care.

Active Immunotherapy to Prevent Alzheimer Disease—A DNA Amyloid β 1-42 Trimer Vaccine

Abstract Full Text
JAMA Neurol. 2020;77(3):289-290. doi:10.1001/jamaneurol.2019.4182

This Viewpoint argues that there is a possibility of finding a path forward in Alzheimer disease prevention with the DNA amyloid β 1-42 timer vaccine that warrants its evaluation in a clinical trial.

On the Brain

Overcoming Neurophobia With the Help of Peruvian Talking Bears

Abstract Full Text
JAMA Neurol. 2020;77(3):291-292. doi:10.1001/jamaneurol.2019.4668

This article describes the case of a juvenile Peruvian talking bear and discusses how it might be used to help medical students overcome neurophobia.

Editorial

Best of JAMA Neurology 2019: Research That Drives Practice

Abstract Full Text
JAMA Neurol. 2020;77(3):293-294. doi:10.1001/jamaneurol.2019.4500

The Narrowing Path for Nilotinib and Other Potential Disease-Modifying Therapies for Parkinson Disease

Abstract Full Text
JAMA Neurol. 2020;77(3):295-297. doi:10.1001/jamaneurol.2019.3983

Potential of Intra-arterial Urokinase After Incomplete Mechanical Thrombectomy—Looking Back, Moving Forward

Abstract Full Text
JAMA Neurol. 2020;77(3):298-299. doi:10.1001/jamaneurol.2019.3984
Original Investigation

Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2020;77(3):300-308. doi:10.1001/jamaneurol.2019.4113

This randomized clinical trial investigates whether fenfluramine reduced monthly convulsive seizure frequency relative to placebo in patients with Dravet syndrome who were already taking stiripentol-inclusive regimens.

Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease: A Phase 2 Randomized Clinical Trial

Abstract Full Text
open access has audio
JAMA Neurol. 2020;77(3):309-317. doi:10.1001/jamaneurol.2019.4200

This randomized clinical trial evaluates the efficacy and safety of nilotinib hydrochloride for use in treatment of patients with Parkinson disease.

Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke

Abstract Full Text
JAMA Neurol. 2020;77(3):318-326. doi:10.1001/jamaneurol.2019.4192

This cohort study assesses whether administration of intra-arterial urokinase is safe and improves reperfusion among patients who have undergone failed or incomplete mechanical thrombectomy.

Association Between Breastfeeding and Postpartum Multiple Sclerosis Relapses: A Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Neurol. 2020;77(3):327-338. doi:10.1001/jamaneurol.2019.4173

This systematic review and meta-analysis examines the occurrence of multiple sclerosis relapses in women who are breastfeeding

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury

Abstract Full Text
open access has active quiz
JAMA Neurol. 2020;77(3):339-349. doi:10.1001/jamaneurol.2019.3854

This single-center observational cohort study aims to comprehensively characterize the spatiotemporal changes in cerebral physiology after traumatic brain injury by comparing a cohort of affected patients with healthy control participants.

Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study

Abstract Full Text
JAMA Neurol. 2020;77(3):350-357. doi:10.1001/jamaneurol.2019.4339

This cross-sectional study examines the association between intracranial atherosclerotic disease and cerebral β-amyloid deposition in adults without dementia enrolled in the Atherosclerosis Risk in Communities Study.

Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia

Abstract Full Text
JAMA Neurol. 2020;77(3):358-366. doi:10.1001/jamaneurol.2019.4284

This study investigates the potential association between tuberous sclerosis–associated neuropsychiatric disorders and frontotemporal dementia.

Survival and Prognostic Factors in C9orf72 Repeat Expansion Carriers: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2020;77(3):367-376. doi:10.1001/jamaneurol.2019.3924

This systematic review and meta-analysis examines prognostic factors in c9 amyotrophic lateral sclerosis, c9 frontotemporal dementia, c9 amyotrophic lateral sclerosis and frontotemporal dementia, and atypical phenotypes.

Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome

Abstract Full Text
open access
JAMA Neurol. 2020;77(3):377-387. doi:10.1001/jamaneurol.2019.4347

This cohort study defines the distinguishing features of progressive supranuclear palsy and corticobasal syndrome and assesses their usefulness in facilitating early diagnosis and separation from Parkinson disease among patients with atypical parkinsonian syndromes.

Images in Neurology

Horizontal and Vertical Boundaries of Hemineglect—The Puzzling Case of a Crossword Puzzle

Abstract Full Text
JAMA Neurol. 2020;77(3):390-391. doi:10.1001/jamaneurol.2019.4814

This case report describes a 65-year-old woman with a right-hemispheric ischemic stroke in the territory of the middle cerebral artery along with left-sided hemiparesis with dysarthria and left-sided visual hemineglect.

JAMA Network Clinical Guideline Synopsis

Pharmacologic Acute and Preventive Treatment for Migraine in Children and Adolescents

Abstract Full Text
JAMA Neurol. 2020;77(3):388-389. doi:10.1001/jamaneurol.2019.4170

This guideline summary provides a review of the American Academy of Neurology and the American Headache Society’s guidelines on Acute Treatment of Migraine in Children and Adolescents and Pharmacologic Treatment for Pediatric Migraine Prevention.

Research Letter

Episodic Visual Snow Associated With Migraine Attacks

Abstract Full Text
JAMA Neurol. 2020;77(3):392-393. doi:10.1001/jamaneurol.2019.4050

This case series describes 3 individuals with episodic visual snow, co-occurring with migraines.

Comment & Response

Alzheimer Disease, Biomarkers, and Clinical Symptoms—Quo Vadis?

Abstract Full Text
JAMA Neurol. 2020;77(3):393-394. doi:10.1001/jamaneurol.2019.4959

Alzheimer Disease, Biomarkers, and Clinical Symptoms—Quo Vadis?—Reply

Abstract Full Text
JAMA Neurol. 2020;77(3):394. doi:10.1001/jamaneurol.2019.4962
Correction

Error in Results

Abstract Full Text
free access
JAMA Neurol. 2020;77(3):394. doi:10.1001/jamaneurol.2019.4873

Data Error in Results

Abstract Full Text
free access
JAMA Neurol. 2020;77(3):394. doi:10.1001/jamaneurol.2020.0139
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2020;77(3):286. doi:10.1001/jamaneurol.2019.3189
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