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June 2019 - July 1959

Decade

Year

Issue

October 2012, Vol 69, No. 10, Pages 1231-1381

Editorial

ONLINE FIRST

TOMM40 Association With Alzheimer Disease: Tales of APOE and Linkage Disequilibrium

Abstract Full Text
Arch Neurol. 2012;69(10):1243-1244. doi:10.1001/archneurol.2012.1935
Original Contribution

Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1270-1279. doi:10.1001/archneurol.2012.2052

Using conditional logistic regression models and survival analysis, Jun et al and the Alzheimer’s Disease Genetics Consortium evaluate the association of risk and age at onset of Alzheimer disease with single-nucleotide polymorphisms in the chromosome 19 region including APOE and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523). In the related editorial, Hardy discusses the association of TOMM40 with Alzheimer disease.

Fingolimod Impedes Schwann Cell–Mediated Myelination: Implications for the Treatment of Immune Neuropathies?

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1280-1289. doi:10.1001/archneurol.2012.394

To assess the effects of FTY720 on Schwann cells (SCs) and peripheral nerve myelination, Köhne and colleagues studied receptor expression studies and myelination in primary rat SCs and rat neuronal/SC cocultures. Cells were treated with physiologically relevant concentrations of the active phosphorylated form of FTY720 (FTY720P).

Results of Phase 2 Safety and Feasibility Study of Treatment With Levetiracetam for Prevention of Posttraumatic Epilepsy

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1290-1295. doi:10.1001/archneurol.2012.445

In an open-label, nonrandomized phase 2 study with 2 arms comparing levetiracetam treatment vs observation, Klein and coauthors evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury who are at high risk for posttraumatic epilepsy.

Dying for the Weekend: A Retrospective Cohort Study on the Association Between Day of Hospital Presentation and the Quality and Safety of Stroke Care

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1296-1302. doi:10.1001/archneurol.2012.1030

Evidence suggests that the quality for care of stroke patients declines on weekends. Palmer and coauthors studied the degree to which the quality and safety of stroke care are affected by whether a patient is admitted on a weekend.

Inhibition of Interferon-beta Responses in Multiple Sclerosis Immune Cells Associated With High-Dose Statins

Abstract Full Text
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Arch Neurol. 2012;69(10):1303-1309. doi:10.1001/archneurol.2012.465

Feng and coauthors examine whether statins affect type 1 interferon responses in relapsing-remitting multiple sclerosis.

Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1310-1317. doi:10.1001/archneurol.2012.1070

To investigate whether a blood-based test could be used as a screen for Alzheimer disease (AD), Soares and colleagues applied a multiplex immunoassay panel to identify plasma biomarkers of AD using plasma samples from the Alzheimer’s Disease Neuroimaging Initiative cohort. They examined differences across mild cognitive impairment, AD, and healthy control groups and relative to the ApoE genotype.

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1318-1325. doi:10.1001/archneurol.2012.1282

Doecke and coauthors studied baseline plasma screening results for 754 healthy individuals and 207 participants with Alzheimer disease (AD) from the Australian Imaging Biomarker and Lifestyle study cohort to identify plasma biomarkers for the diagnosis of AD.

Pathologic Accumulation of α-Synuclein and Aβ in Parkinson Disease Patients With Dementia

Abstract Full Text
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Arch Neurol. 2012;69(10):1326-1331. doi:10.1001/archneurol.2012.1608

Kotzbauer and coauthors examine the relative contributions of individual molecular mechanisms that occur in dementia associated with Parkinson disease.

Association of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1332-1339. doi:10.1001/archneurol.2012.1541

Shortening of telomere length is a consequence of aging. Honig and coauthors examined the possible relation of telomere length with development of dementia and mortality.

Diffusion Tensor Imaging of Vascular Parkinsonism: Structural Changes in Cerebral White Matter and the Association With Clinical Severity

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1340-1348. doi:10.1001/archneurol.2012.633

Little is known about associations between the clinical status of vascular parkinsonism (VP) and white matter (WM) microstructural properties derived from imaging data for specific fiber bundles. Wang et al investigated WM microstructure in VP using diffusion tensor imaging.

Clinical Implications of Basic Neuroscience Research

Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1255-1258. doi:10.1001/archneurol.2012.540

Wagner et al discuss .-secretase inhibition and .-secretase modulation as approaches to disease-modifying therapeutics capable of substantially altering the clinical course of Alzheimer disease and emphasize their significant differences. They also discuss genetic- and biomarker-based translational and clinical trial paradigms that may assist in developing a useful therapeutic agent.

Clinical Pathologic Conference

Slowly Progressive Ataxia, Neuropathy, and Oculomotor Dysfunction

Abstract Full Text
free access has multimedia
Arch Neurol. 2012;69(10):1366-1371. doi:10.1001/archneurol.2012.2356

Jordan et al describe a patient with slowly progressive ataxia, neuropathy, and oculomotor dysfunction. The authors discuss the differential diagnosis and a methodological approach to the diagnostic workup before revealing the final diagnosis.

Images in Neurology

Widely Metastatic Meningioma

Abstract Full Text
Arch Neurol. 2012;69(10):1372-1373. doi:10.1001/archneurol.2012.1

Callosal Disconnection Syndrome in a Patient With Corpus Callosum Hemorrhage: A Diffusion Tensor Tractography Study

Abstract Full Text
Arch Neurol. 2012;69(10):1374-1375. doi:10.1001/archneurol.2012.48

The Importance of Susceptibility-Weighted Imaging in Familial Cerebral Cavernous Malformation

Abstract Full Text
Arch Neurol. 2012;69(10):1376-1377. doi:10.1001/archneurol.2012.96
Research Letter

Cerebral and Cervical Venous Outflow Abnormalities Are Dynamic

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1380-1381. doi:10.1001/archneurol.2012.1938
Observation

Prominent Sensorimotor Neuropathy Due to SACS Mutations Revealed by Whole-Exome Sequencing

Abstract Full Text
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Arch Neurol. 2012;69(10):1351-1354. doi:10.1001/archneurol.2012.1472

Pyle et al determine the genetic basis of an unexplained multisystem neurological disorder affecting 2 siblings.

Hypothermia, Hypotension, Hypersomnia, and Obesity Associated With Hypothalamic Lesions in a Patient Positive for the Anti–aquaporin 4 Antibody: A Case Report and Literature Review

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1355-1359. doi:10.1001/archneurol.2012.300

Suzuki and colleagues described a 21-year-old woman who was positive for anti– aquaporin 4 (AQP4) antibody and presented with hypothermia, hypotension, and hypersomnia owing to bilateral hypothalamic lesions as the only abnormal clinical finding.

Frequency of the D620N Mutation in VPS35 in Parkinson Disease

Abstract Full Text
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Arch Neurol. 2012;69(10):1360-1364. doi:10.1001/archneurol.2011.3367

In a genetic analysis, Kumar et al evaluate the frequency and clinical spectrum of the recently identified p.D620N mutation in the VPS35 gene in Parkinson disease in an international sample.

Book Reviews

The Cradle of American Neurology: The Harvard Neurological Unit at the Boston City Hospital

Abstract Full Text
Arch Neurol. 2012;69(10):1378-1379. doi:10.1001/archneurol.2012.1822
This Month in Archives of Neurology

This Month in Archives of Neurology

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1237-1238. doi:10.1001/archneurol.2011.1479
Neurological Review

Dementia Resulting From Traumatic Brain Injury: What Is the Pathology?

Abstract Full Text
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Arch Neurol. 2012;69(10):1245-1251. doi:10.1001/archneurol.2011.3747

Shively et al review the epidemiologic data linking traumatic brain injury and dementia, existing clinical and pathologic data, and will identify areas where future research is needed.

Clinical Trials

Impact of Fingolimod Therapy on Magnetic Resonance Imaging Outcomes in Patients With Multiple Sclerosis

Abstract Full Text
free access
Arch Neurol. 2012;69(10):1259-1269. doi:10.1001/archneurol.2012.1051

In a worldwide, multicenter clinical trial, Radue et al for the FREEDOMS Study Group assess the impact of fingolimod (FTY720) therapy on magnetic resonance imaging measures of inflammatory activity and tissue damage in patients participating in a 2-year, placebo-controlled, phase 3 study.

Commentary in Neurology

Psychogenic Nonepileptic Seizures: Time to Abandon the Term Pseudoseizures

Abstract Full Text
Arch Neurol. 2012;69(10):1349-1350. doi:10.1001/archneurol.2012.829
Correspondence

Age, Statin Use, and the Risk for Incident Parkinson Disease

Abstract Full Text
Arch Neurol. 2012;69(10):1381. doi:10.1001/archneurol.2012.1132

Age, Statin Use, and the Risk for Incident Parkinson Disease—Reply

Abstract Full Text
Arch Neurol. 2012;69(10):1381. doi:10.1001/archneurol.2012.2032
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