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June 2012, Vol 69, No. 6, Pages 687-794

Editorial
Original Contribution

Amyloid-β–Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau

Abstract Full Text
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Arch Neurol. 2012;69(6):709-713. doi:10.1001/archneurol.2011.3354

Desikan and colleagues examined 107 patients with a Clinical Dementia Rating of 0 at baseline to elucidate the relationship between amyloid-β (Aβ) and tau and clinical decline over time among cognitively normal subjects. In an editorial, Holtzman provides a comment.

Evidence of Intrathecal Immunoglobulin Synthesis in Stroke: A Cohort Study

Abstract Full Text
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Arch Neurol. 2012;69(6):714-717. doi:10.1001/archneurol.2011.3252

In a retrospective cohort study, Prüss and colleagues investigate the frequency of intrathecal immunoglobulin synthesis in a well-characterized cohort of 318 patients who experienced “noninflammatory” acute stroke.

Novel Infantile-Onset Leukoencephalopathy With High Lactate Level and Slow Improvement

Abstract Full Text
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Arch Neurol. 2012;69(6):718-722. doi:10.1001/archneurol.2011.1048

In a retrospective review, Steenweg et al describe a novel pattern of magnetic resonance imaging abnormalities as well as the associated clinical and laboratory findings.

Restricted Diffusion in Vanishing White Matter

Abstract Full Text
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Arch Neurol. 2012;69(6):723-727. doi:10.1001/archneurol.2011.1658

Van der Lei and colleagues conducted a retrospective observational study of 46 patients with vanishing white matter (VWM) with the aim of investigating the occurrence of restricted diffusion in VWM, the affected structures, the time of occurrence in the disease course, and the histopathologic correlate.

Myopathy Associated With Antibodies to Signal Recognition Particle: Disease Progression and Neurological Outcome

Abstract Full Text
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Arch Neurol. 2012;69(6):728-732. doi:10.1001/archneurol.2011.1728

Suzuki et al characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy.

Clinical Prediction of Fall Risk and White Matter Abnormalities: A Diffusion Tensor Imaging Study

Abstract Full Text
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Arch Neurol. 2012;69(6):733-738. doi:10.1001/archneurol.2011.2272

Koo et al test the hypothesis that elderly subjects at risk for falling, as determined by the Tinetti scale, have specific patterns of white matter abnormalities on diffusion tensor imaging.

Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage: A Comparative Ultrahigh-Field Strength Magnetic Resonance Imaging Study

Abstract Full Text
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Arch Neurol. 2012;69(6):739-745. doi:10.1001/archneurol.2011.2450

In a comparative study, Sinnecker and coauthors demonstrate the potential of ultrahigh-field 3-dimensional T1-weighted imaging using magnetization-prepared rapid acquisition and multiple gradient-echoes to detect and characterize white and gray matter pathology in multiple sclerosis.

Mutational Origin of Machado-Joseph Disease in the Australian Aboriginal Communities of Groote Eylandt and Yirrkala

Abstract Full Text
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Arch Neurol. 2012;69(6):746-751. doi:10.1001/archneurol.2011.2504

Martins et al investigates whether the presence of Machado-Joseph disease (MJD, also spinocerebellar ataxia type 3 [SCA3]) among Australian aborigines was caused by a new mutational event or to the introduction of expanded alleles from other populations.

Anti–Myelin Oligodendrocyte Glycoprotein Antibodies in Pediatric Patients With Optic Neuritis

Abstract Full Text
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Arch Neurol. 2012;69(6):752-756. doi:10.1001/archneurol.2011.2956

In an observational prospective case series, Rostasy and coauthors recruited 37 pediatric patients with optic neuritis from 6 different hospitals in Germany and Austria to study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG) in pediatric patients with isolated or recurrent optic neuritis.

Plasma Signaling Proteins in Persons at Genetic Risk for Alzheimer Disease: Influence of APOE Genotype

Abstract Full Text
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Arch Neurol. 2012;69(6):757-764. doi:10.1001/archneurol.2012.277

Ringman and coauthors measured the levels of proteins in familial Alzheimer disease mutation carriers and noncarriers and among APOE genotype groups to evaluate the association between the inflammatory markers and risk for Alzheimer disease.

Images in Neurology

Metastatic Renal Cell Carcinoma With Radiologic Appearance of a Meningioma

Abstract Full Text
Arch Neurol. 2012;69(6):780-781. doi:10.1001/archneurol.2011.500

Never Neglect Inspecting the Leg in Movement Disorders

Abstract Full Text
Arch Neurol. 2012;69(6):782-783. doi:10.1001/archneurol.2011.1523

Brain Air Embolism Secondary to Atrial-Esophageal Fistula

Abstract Full Text
Arch Neurol. 2012;69(6):785. doi:10.1001/archneurol.2011.1896

Dural Arteriovenous Fistula of the Medulla Initially Mimicking Guillain-Barré Syndrome

Abstract Full Text
Arch Neurol. 2012;69(6):786-787. doi:10.1001/archneurol.2011.2934
Research Letter

Mutations in the TRPV4 Gene Are Not Associated With Sporadic Progressive Muscular Atrophy

Abstract Full Text
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Arch Neurol. 2012;69(6):790-791. doi:10.1001/archneurol.2012.148
Observation

Adult-Onset Vanishing White Matter Disease Due to a Novel EIF2B3 Mutation

Abstract Full Text
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Arch Neurol. 2012;69(6):765-768. doi:10.1001/archneurol.2011.1942

La Piana et al report a novel mutation in the gene EIF2B3 responsible for a lateonset form of vanishing white matter disease.

Vitamin B12 Deficiency With Bilateral Globus Pallidus Abnormalities

Abstract Full Text
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Arch Neurol. 2012;69(6):769-772. doi:10.1001/archneurol.2011.1084

Sharrief et al describe a case of vitamin B12 deficiency with classic and rare clinical features and novel radiographic features.

CD4+ T Cells Predominate in Cerebrospinal Fluid and Leptomeningeal and Parenchymal Infiltrates in Cerebral Amyloid β–Related Angiitis

Abstract Full Text
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Arch Neurol. 2012;69(6):773-777. doi:10.1001/archneurol.2011.2441

To describe the cellular composition of inflammatory infiltrates in the cerebrospinal fluid and central nervous system and their response to immunotherapy in amyloid β–related angiitis, Melzer and colleagues perform neurologic examination, magnetic resonance imaging, lumbar puncture, flow cytometry, leptomeningeal biopsy, and histopathologic analysis on a 67-year-old white woman.

Adult-Onset Cerebral Folate Deficiency

Abstract Full Text
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Arch Neurol. 2012;69(6):778-779. doi:10.1001/archneurol.2011.3036

New manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome, in an adult is described by Sadigi and colleagues.

Book Reviews

Core Topics in Neuroanesthesia and Neurointensive Care

Abstract Full Text
Arch Neurol. 2012;69(6):788-789. doi:10.1001/archneurol.2012.165
This Month in Archives of Neurology

This Month in Archives of Neurology

Abstract Full Text
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Arch Neurol. 2012;69(6):688-689. doi:10.1001/archneurol.2011.1459
Neurological Review

Maternal Autoantibodies in Autism

Abstract Full Text
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Arch Neurol. 2012;69(6):693-699. doi:10.1001/archneurol.2011.2506

Braunschweig and Van de Water reviewed the current literature on autism spectrum disorders and proposed directions for future research.

Special Article

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia

Abstract Full Text
Arch Neurol. 2012;69(6):700-708. doi:10.1001/archneurol.2011.3152

In a retrospective review of ratings of functional impairment across diagnostic categories, Morris evaluates the potential impact of revised criteria for mild cognitive impairment, developed by a work group sponsored by the National Institute on Aging and the Alzheimer’s Association, on the diagnosis of very mild and mild Alzheimer disease dementia.

Correspondence

Superficial Siderosis, Traumatic Tap, and Xanthochromia

Abstract Full Text
Arch Neurol. 2012;69(6):791-792. doi:10.1001/archneurol.2012.132

Superficial Siderosis, Traumatic Tap, and Xanthochromia—Reply

Abstract Full Text
Arch Neurol. 2012;69(6):791-792. doi:10.1001/archneurol.2012.135

Reversible Postpartum Cerebral Vasoconstriction Syndrome

Abstract Full Text
Arch Neurol. 2012;69(6):792-793. doi:10.1001/archneurol.2012.211

Reversible Postpartum Cerebral Vasoconstriction Syndrome—Reply

Abstract Full Text
Arch Neurol. 2012;69(6):792-793. doi:10.1001/archneurol.2012.214

Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring

Abstract Full Text
Arch Neurol. 2012;69(6):793-794. doi:10.1001/archneurol.2012.200

Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring—Reply

Abstract Full Text
Arch Neurol. 2012;69(6):793-794. doi:10.1001/archneurol.2012.203
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