Desikan and colleagues examined 107 patients with a Clinical Dementia Rating of 0 at baseline to elucidate the relationship between amyloid-β (Aβ) and tau and clinical decline over time among cognitively normal subjects. In an editorial, Holtzman provides a comment.
In a retrospective cohort study, Prüss and colleagues investigate the frequency of intrathecal immunoglobulin synthesis in a well-characterized cohort of 318 patients who experienced “noninflammatory” acute stroke.
In a retrospective review, Steenweg et al describe a novel pattern of magnetic resonance imaging abnormalities as well as the associated clinical and laboratory findings.
Van der Lei and colleagues conducted a retrospective observational study of 46 patients with vanishing white matter (VWM) with the aim of investigating the occurrence of restricted diffusion in VWM, the affected structures, the time of occurrence in the disease course, and the histopathologic correlate.
Suzuki et al characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy.
Koo et al test the hypothesis that elderly subjects at risk for falling, as determined by the Tinetti scale, have specific patterns of white matter abnormalities on diffusion tensor imaging.
In a comparative study, Sinnecker and coauthors demonstrate the potential of ultrahigh-field 3-dimensional T1-weighted imaging using magnetization-prepared rapid acquisition and multiple gradient-echoes to detect and characterize white and gray matter pathology in multiple sclerosis.
Martins et al investigates whether the presence of Machado-Joseph disease (MJD, also spinocerebellar ataxia type 3 [SCA3]) among Australian aborigines was caused by a new mutational event or to the introduction of expanded alleles from other populations.
In an observational prospective case series, Rostasy and coauthors recruited 37 pediatric patients with optic neuritis from 6 different hospitals in Germany and Austria to study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG) in pediatric patients with isolated or recurrent optic neuritis.
Ringman and coauthors measured the levels of proteins in familial Alzheimer disease mutation carriers and noncarriers and among APOE genotype groups to evaluate the association between the inflammatory markers and risk for Alzheimer disease.
La Piana et al report a novel mutation in the gene EIF2B3 responsible for a lateonset form of vanishing white matter disease.
Sharrief et al describe a case of vitamin B12 deficiency with classic and rare clinical features and novel radiographic features.
To describe the cellular composition of inflammatory infiltrates in the cerebrospinal fluid and central nervous system and their response to immunotherapy in amyloid β–related angiitis, Melzer and colleagues perform neurologic examination, magnetic resonance imaging, lumbar puncture, flow cytometry, leptomeningeal biopsy, and histopathologic analysis on a 67-year-old white woman.
New manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome, in an adult is described by Sadigi and colleagues.
Braunschweig and Van de Water reviewed the current literature on autism spectrum disorders and proposed directions for future research.
In a retrospective review of ratings of functional impairment across diagnostic categories, Morris evaluates the potential impact of revised criteria for mild cognitive impairment, developed by a work group sponsored by the National Institute on Aging and the Alzheimer’s Association, on the diagnosis of very mild and mild Alzheimer disease dementia.
Create a personal account or sign in to: