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July 2019 - July 1959

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Issue

September 2012, Vol 69, No. 9, Pages 1100-1214

Original Contribution

Human Aquaporin 4281-300 Is the Immunodominant Linear Determinant in the Context of HLA-DRB1*03:01: Relevance for Diagnosing and Monitoring Patients With Neuromyelitis Optica

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Arch Neurol. 2012;69(9):1125-1131. doi:10.1001/archneurol.2012.1300

Arellano and coauthors aim to identify linear determinants of hAQP4 in the context of HLA-DRb1*03:01. See also the editorial by 1561.

Cellular Immune Suppression in Paraneoplastic Neurologic Syndromes Targeting Intracellular Antigens

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Arch Neurol. 2012;69(9):1132-1140. doi:10.1001/archneurol.2012.595

Orange and colleagues conducted a retrospective case series of 26 patients with paraneoplastic neurologic disorders (PNDs) to evaluate the short-term use of a combination of prednisone and tacrolimus for acute neurologic worsening in PND in which intracellular antigens are targeted.

Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer Disease

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Arch Neurol. 2012;69(9):1141-1148. doi:10.1001/archneurol.2012.590

Smith and coauthors used an open-label trial to test the hypotheses that deep brain stimulation would increase cerebral glucose metabolism in cortical and hippocampal circuits and that increased metabolism would be correlated with better clinical outcomes.

Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 Mutation

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Arch Neurol. 2012;69(9):1149-1153. doi:10.1001/archneurol.2012.650

Takada et al describe the clinical features of a Brazilian kindred with C9orf72 frontotemporal dementia–amyotrophic lateral sclerosis and compare them with other described families with C9orf72 and frontotemporal dementia–amyotrophic lateral sclerosis–causing mutations.

C9ORF72 Repeat Expansion in Amyotrophic Lateral Sclerosis in the Kii Peninsula of Japan

Abstract Full Text
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Arch Neurol. 2012;69(9):1154-1158. doi:10.1001/archneurol.2012.1219

To delineate the molecular basis of amyotrophic lateral sclerosis (ALS) in the Kii peninsula of Japan, Ishiura and colleagues analyzed hexanucleotide repeat expansion in the chromosome 9 open reading frame 72 gene (C9ORF72).

C9orf72 Hexanucleotide Repeat Expansions as the Causative Mutation for Chromosome 9p21–Linked Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Abstract Full Text
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Arch Neurol. 2012;69(9):1159-1163. doi:10.1001/archneurol.2012.377

Daoud et al assess the presence of a large hexanucleotide repeat expansion in the first intron of the C9orf72 gene, identified as the genetic cause of chromosome 9p21–linked amyotrophic lateral sclerosis and frontotemporal dementia, in 4 unrelated families.

Characterization of a Family With c9FTD/ALS Associated With the GGGGCC Repeat Expansion in C9ORF72

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Arch Neurol. 2012;69(9):1164-1169. doi:10.1001/archneurol.2012.772

Savica and colleagues conducted a clinical series to characterize the antemortem characteristics of a family with frontotemporal dementia (FTD) and/or amyotrophic lateral sclerosis (ALS) linked to chromosome 9 (c9FTD/ALS) associated with the GGGGCC repeat expansion in the chromosome 9 open reading frame 72 (C9ORF72) gene.

Diabetes, Glucose Control, and 9-Year Cognitive Decline Among Older Adults Without Dementia

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Arch Neurol. 2012;69(9):1170-1175. doi:10.1001/archneurol.2012.1117

In a prospective cohort study, Yaffe et al determine if prevalent and incident diabetes mellitus increase risk of cognitive decline and if, among elderly adults with diabetes mellitus, poor glucose control is related to worse cognitive performance.

Epidemiology of Neuromyelitis Optica in the United States: A Multicenter Analysis

Abstract Full Text
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Arch Neurol. 2012;69(9):1176-1180. doi:10.1001/archneurol.2012.314

With a prevalence of approximately 1% to 2% that of multiple sclerosis, neuromyelitis optica (NMO) and its spectrum disorders are rare in the United States. Mealy and coauthors developed a multicenter NMO clinical consortium of 3 tertiary centers to facilitate accurate clinical diagnosis and establish a foundation for future research.

Distinct Patterns of Antiamyloid-β Antibodies in Typical and Atypical Alzheimer Disease

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Arch Neurol. 2012;69(9):1181-1185. doi:10.1001/archneurol.2012.604

Dorothée and colleagues compare serum antiamyloid-β antibodies in typical and atypical Alzheimer disease using an oligomer-based enzyme-linked immunosorbent assay.

Association of Cerebral Microbleeds in Acute Ischemic Stroke With High Serum Levels of Vascular Endothelial Growth Factor

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Arch Neurol. 2012;69(9):1186-1189. doi:10.1001/archneurol.2012.459

Dassan and coauthors used a cross-sectional study to investigate whether vascular endothelial growth factor (VEGF) levels are associated with the presence of cerebral microbleeds in patients after acute ischemic stroke.

Clinical Implications of Basic Neuroscience Research

Link Between Pain and Olfaction in an Inherited Sodium Channelopathy

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Arch Neurol. 2012;69(9):1119-1123. doi:10.1001/archneurol.2012.21

The voltage-gated sodium channel Nav1.7 plays roles in the human sense of smell and perception of pain. Zufall and coauthors review possible links between these sensory functions and sodium channelopathy.

Images in Neurology

Multiple Fusiform Intracranial Aneurysms 14 Years After Atrial Myxoma Resection

Abstract Full Text
Arch Neurol. 2012;69(9):1204-1205. doi:10.1001/archneurol.2011.3503

Multiple Septic Brain Emboli in Infectious Endocarditis

Abstract Full Text
Arch Neurol. 2012;69(9):1206-1207. doi:10.1001/archneurol.2011.3563
Observation

A Novel Mutation in PNPLA2 Leading to Neutral Lipid Storage Disease With Myopathy

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Arch Neurol. 2012;69(9):1190-1192. doi:10.1001/archneurol.2011.2600

Ash and coauthors report the clinical and molecular features of a case of neutral lipid storage disease with myopathy resulting from a novel mutation in PNPLA2.

Fatal Varicella-Zoster Virus Vasculopathy Associated With Adalimumab Therapy

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Arch Neurol. 2012;69(9):1193-1196. doi:10.1001/archneurol.2011.3741

Baek et al describe the case of a patient who had been receiving adalimumab for rheumatoid arthritis and died of varicella-zoster virus vasculopathy with multifocal cerebral hemorrhage.

Atrial Fibrillation Associated With Epileptic Seizures

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Arch Neurol. 2012;69(9):1197-1199. doi:10.1001/archneurol.2011.3647

Herskovitz and Schiller describe and characterize patients who experienced lone atrial fibrillation or atrial flutter as a consequence of epileptic seizures.

Two in One: Report of a Patient With Spinocerebellar Ataxia Types 2 and 10

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Arch Neurol. 2012;69(9):1200-1203. doi:10.1001/archneurol.2011.3044

Kapur and Goldman report a rare case of the coexistence of 2 spinocerebellar ataxia mutations in a single patient.

Book Reviews

The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children

Abstract Full Text
Arch Neurol. 2012;69(9):1212-1213. doi:10.1001/archneurol.2012.1266

McLean Course in Electrodiagnostic Medicine

Abstract Full Text
Arch Neurol. 2012;69(9):1213. doi:10.1001/archneurol.2012.1705
Obituary

In Memoriam: Charles Miller Fisher, MD (1913-2012)

Abstract Full Text
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Arch Neurol. 2012;69(9):1208-1209. doi:10.1001/archneurol.2012.1743
This Month in Archives of Neurology

This Month in Archives of Neurology

Abstract Full Text
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Arch Neurol. 2012;69(9):1104-1105. doi:10.1001/archneurol.2011.1474
Neurological Review

The Genetics of Dementia With Lewy Bodies: What Are We Missing?

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Arch Neurol. 2012;69(9):1113-1118. doi:10.1001/archneurol.2011.3678

Meeus and colleagues provide a comprehensive overview of the current studies on dementia with Lewy bodies heritability, genetic etiology, and genetic heterogeneity. They conclude with a critical discussion of the missing heritability in dementia with Lewy bodies.

Correspondence

Primary Progressive Aphasia and Transient Global Amnesia

Abstract Full Text
Arch Neurol. 2012;69(9):1214. doi:10.1001/archneurol.2012.1647
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