Chatterjee et al perform a systematic review and meta-analysis to quantitatively assess the rates of intracranial hemorrhage within the framework of both conventional and Bayesian statistics. Hart et al provide commentary in a related editorial.
Gonzaga-Jauregui et al elucidate the molecular cause of a complex neuropathy phenotype in 3 patients by applying genomic sequencing strategies.
Hocker et al develop a model to differentiate central from infectious fever in critically ill neurologic patients with fever of an undetermined cause.
Su et al identify biomarkers in the plasma and cerebrospinal fluid of patients with amyotrophic lateral sclerosis that can predict prognosis.
Wirth et al examine relationships between β-amyloid and non–β-amyloid factors as well as neurodegeneration within Alzheimer disease regions in cognitively normal older adults.
Dorsey et al determine the longitudinal change in clinical features among individuals with Huntington disease compared with controls.
Clardy and colleagues conducted a medical record review and serological evaluation to describe patients with disorders in the stiff-man syndrome spectrum beginning in childhood.
Spira et al examine the association between self-reported sleep variables and β-amyloid deposition in community-dwelling older adults.
Lim et al determine whether better sleep consolidation attenuates the relationship of the APOE genotype to the risk of incident AD and the burden of AD pathology in a long-term follow-up study of community-dwelling elderly individuals without dementia.
Mitochondrial DNA (mtDNA) disorders have emerged as major causes of inherited neurologic disease. Spyropoulos and colleagues provided a case report describing monozygotic male twins with ptosis, optic atrophy, and recent-onset intractable myoclonic epilepsy. Salvatore DiMauro, MD, provided a related Article .
Pitceathly and coauthors describe an adult patient with isolated cytochrome-c oxidase deficiency associated with a relatively mild clinical phenotype comprising myopathy; demyelinating neuropathy; premature ovarian failure; short stature; hearing loss, with pigmentary maculopathy; and renal tubular dysfunction. Whole-exome sequencing detected 1 known pathogenic and 1 novel COX10 mutation.
de Carvalho et al used a double-electrode recording technique in a single muscle to detect time-locked fasciculation potentials.
Thomas et al present a case of a 39-year-old woman who developed psychiatric symptoms that progressed to encephalopathy, seizures, autonomic instability, and hyperkinetic movements.
Zipp and coauthors noted that although multiple sclerosis (MS) has long been considered a primarily inflammatory, demyelinating disease of the central nervous system, modern histopathology and imaging techniques show that neurodegenerative processes also have a definitive role in MS pathology. They reviewed reports from the last decade and outlined clinical results on the topic.
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