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September 2021 - July 1959

Decade

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Issue

December 2013, Vol 70, No. 12, Pages 1465-1593

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2013;70(12):1465-1467. doi:10.1001/jamaneurol.2013.2897
Viewpoint

The Role of the Neurologist in Concussions: When to Tell Your Patient to Stop

Abstract Full Text
JAMA Neurol. 2013;70(12):1481-1482. doi:10.1001/jamaneurol.2013.3231
Editorial

Direct-Acting Oral Anticoagulants: The Brain Gets a Break

Abstract Full Text
JAMA Neurol. 2013;70(12):1483-1484. doi:10.1001/jamaneurol.2013.4347

Mitochondrial DNA Mutation Load: Chance or Destiny?

Abstract Full Text
JAMA Neurol. 2013;70(12):1484-1485. doi:10.1001/jamaneurol.2013.4401
Original Investigation

New Oral Anticoagulants and the Risk of Intracranial Hemorrhage: Traditional and Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials of New Oral Anticoagulants in Atrial Fibrillation

Abstract Full Text
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JAMA Neurol. 2013;70(12):1486-1490. doi:10.1001/jamaneurol.2013.4021

Chatterjee et al perform a systematic review and meta-analysis to quantitatively assess the rates of intracranial hemorrhage within the framework of both conventional and Bayesian statistics. Hart et al provide commentary in a related editorial.

Mutations in VRK1 Associated With Complex Motor and Sensory Axonal Neuropathy Plus Microcephaly

Abstract Full Text
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JAMA Neurol. 2013;70(12):1491-1498. doi:10.1001/jamaneurol.2013.4598

Gonzaga-Jauregui et al elucidate the molecular cause of a complex neuropathy phenotype in 3 patients by applying genomic sequencing strategies.

Indicators of Central Fever in the Neurologic Intensive Care Unit

Abstract Full Text
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JAMA Neurol. 2013;70(12):1499-1504. doi:10.1001/jamaneurol.2013.4354

Hocker et al develop a model to differentiate central from infectious fever in critically ill neurologic patients with fever of an undetermined cause.

Biomarker-Based Predictive Models for Prognosis in Amyotrophic Lateral Sclerosis

Abstract Full Text
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JAMA Neurol. 2013;70(12):1505-1511. doi:10.1001/jamaneurol.2013.4646

Su et al identify biomarkers in the plasma and cerebrospinal fluid of patients with amyotrophic lateral sclerosis that can predict prognosis.

Associations Between Alzheimer Disease Biomarkers, Neurodegeneration, and Cognition in Cognitively Normal Older People

Abstract Full Text
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JAMA Neurol. 2013;70(12):1512-1519. doi:10.1001/jamaneurol.2013.4013

Wirth et al examine relationships between β-amyloid and non–β-amyloid factors as well as neurodegeneration within Alzheimer disease regions in cognitively normal older adults.

Natural History of Huntington Disease

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JAMA Neurol. 2013;70(12):1520-1530. doi:10.1001/jamaneurol.2013.4408

Dorsey et al determine the longitudinal change in clinical features among individuals with Huntington disease compared with controls.

Childhood Onset of Stiff-Man Syndrome

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JAMA Neurol. 2013;70(12):1531-1536. doi:10.1001/jamaneurol.2013.4442

Clardy and colleagues conducted a medical record review and serological evaluation to describe patients with disorders in the stiff-man syndrome spectrum beginning in childhood.

Self-reported Sleep and β-Amyloid Deposition in Community-Dwelling Older Adults

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JAMA Neurol. 2013;70(12):1537-1543. doi:10.1001/jamaneurol.2013.4258

Spira et al examine the association between self-reported sleep variables and β-amyloid deposition in community-dwelling older adults.

Modification of the Relationship of the Apolipoprotein E ε4 Allele to the Risk of Alzheimer Disease and Neurofibrillary Tangle Density by Sleep

Abstract Full Text
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JAMA Neurol. 2013;70(12):1544-1551. doi:10.1001/jamaneurol.2013.4215

Lim et al determine whether better sleep consolidation attenuates the relationship of the APOE genotype to the risk of incident AD and the burden of AD pathology in a long-term follow-up study of community-dwelling elderly individuals without dementia.

Case Report/Case Series

Near-Identical Segregation of mtDNA Heteroplasmy in Blood, Muscle, Urinary Epithelium, and Hair Follicles in Twins With Optic Atrophy, Ptosis, and Intractable Epilepsy

Abstract Full Text
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JAMA Neurol. 2013;70(12):1552-1555. doi:10.1001/jamaneurol.2013.4111

Mitochondrial DNA (mtDNA) disorders have emerged as major causes of inherited neurologic disease. Spyropoulos and colleagues provided a case report describing monozygotic male twins with ptosis, optic atrophy, and recent-onset intractable myoclonic epilepsy. Salvatore DiMauro, MD, provided a related Article .

COX10 Mutations Resulting in Complex Multisystem Mitochondrial Disease That Remains Stable Into Adulthood

Abstract Full Text
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JAMA Neurol. 2013;70(12):1556-1561. doi:10.1001/jamaneurol.2013.3242

Pitceathly and coauthors describe an adult patient with isolated cytochrome-c oxidase deficiency associated with a relatively mild clinical phenotype comprising myopathy; demyelinating neuropathy; premature ovarian failure; short stature; hearing loss, with pigmentary maculopathy; and renal tubular dysfunction. Whole-exome sequencing detected 1 known pathogenic and 1 novel COX10 mutation.

Origin of Fasciculations in Amyotrophic Lateral Sclerosis and Benign Fasciculation Syndrome

Abstract Full Text
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JAMA Neurol. 2013;70(12):1562-1565. doi:10.1001/jamaneurol.2013.4437

de Carvalho et al used a double-electrode recording technique in a single muscle to detect time-locked fasciculation potentials.

Anti–N-Methyl-d-Aspartate Receptor Encephalitis: A Patient With Refractory Illness After 25 Months of Intensive Immunotherapy

Abstract Full Text
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JAMA Neurol. 2013;70(12):1566-1568. doi:10.1001/jamaneurol.2013.3205

Thomas et al present a case of a 39-year-old woman who developed psychiatric symptoms that progressed to encephalopathy, seizures, autonomic instability, and hyperkinetic movements.

Review

Identification of Inflammatory Neuronal Injury and Prevention of Neuronal Damage in Multiple Sclerosis: Hope for Novel Therapies?

Abstract Full Text
JAMA Neurol. 2013;70(12):1569-1574. doi:10.1001/jamaneurol.2013.4391

Zipp and coauthors noted that although multiple sclerosis (MS) has long been considered a primarily inflammatory, demyelinating disease of the central nervous system, modern histopathology and imaging techniques show that neurodegenerative processes also have a definitive role in MS pathology. They reviewed reports from the last decade and outlined clinical results on the topic.

Images in Neurology

Detection of Cerebrospinal Fluid Leaks by Intrathecal Contrast-Enhanced Magnetic Resonance Myelography

Abstract Full Text
JAMA Neurol. 2013;70(12):1576-1577. doi:10.1001/jamaneurol.2013.744

Not So Small Vessel Vasculitis

Abstract Full Text
JAMA Neurol. 2013;70(12):1578-1579. doi:10.1001/2013.jamaneurol.565

Churg-Strauss Syndrome: An Uncommon Cause of Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2013;70(12):1580-1581. doi:10.1001/2013.jamaneurol.414

Oculomotor Nerve Palsy as the Presenting Symptom of Gummatous Neurosyphilis and Human Immunodeficiency Virus Infection: Clinical Response to Treatment

Abstract Full Text
JAMA Neurol. 2013;70(12):1582-1583. doi:10.1001/jamaneurol.2013.1485

Recovery From Ophthalmoplegia and Proptosis After Repair of Bilateral Carotid-Cavernous Sinus Fistulas

Abstract Full Text
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JAMA Neurol. 2013;70(12):1584-1585. doi:10.1001/jamaneurol.2013.1515

Recurrence of Coccidioidal Meningitis After Discontinuation of Fluconazole

Abstract Full Text
JAMA Neurol. 2013;70(12):1586. doi:10.1001/jamaneurol.2013.1139
Comment & Response

Proximal Lower-Limb Weakness in Charcot-Marie-Tooth Disease

Abstract Full Text
JAMA Neurol. 2013;70(12):1587. doi:10.1001/jamaneurol.2013.4662

Proximal Lower-Limb Weakness in Charcot-Marie-Tooth Disease—Reply

Abstract Full Text
JAMA Neurol. 2013;70(12):1587-1588. doi:10.1001/jamaneurol.2013.4770

Creutzfeldt-Jakob Disease

Abstract Full Text
JAMA Neurol. 2013;70(12):1588-1589. doi:10.1001/jamaneurol.2013.4412

Next-Generation Phenotyping and Genomic Incidental Findings: Beyond the Parkin Example

Abstract Full Text
JAMA Neurol. 2013;70(12):1589. doi:10.1001/jamaneurol.2013.4521

Creutzfeldt-Jakob Disease—Reply

Abstract Full Text
JAMA Neurol. 2013;70(12):1589. doi:10.1001/jamaneurol.2013.4777

Next-Generation Phenotyping and Genomic Incidental Findings—Reply

Abstract Full Text
JAMA Neurol. 2013;70(12):1590-1591. doi:10.1001/jamaneurol.2013.4812
Book and Media Review

Review of Neurological Disorders Due to Systemic Disease

Abstract Full Text
JAMA Neurol. 2013;70(12):1592. doi:10.1001/jamaneurol.2013.4415

Review of Sleep Deprivation, Stimulant Medications, and Cognition

Abstract Full Text
JAMA Neurol. 2013;70(12):1592-1593. doi:10.1001/jamaneurol.2013.4576
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2013;70(12):1476. doi:10.1001/jamaneurol.2013.2895
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