In a cross-sectional comparison of measurements of cerebral glucose metabolism and brain volume in cognitively normal, late-middle-aged persons, Protas and coauthors characterize and compare the measurements so as to distinguish these persons with 2, 1, or 0 copies of the APOE ϵ4 allele, reflecting 3 levels of risk for late-onset Alzheimer disease. See editorial by Jagust.
Hart et al assessed the prevalence of cognitive impairment and depression in a sample of former National Football League (NFL) players and identified neuroimaging correlates of these dysfunctions. See also the editorial by Diaz-Arrastia.
In an observational study, Erbayat Altay et al assess the reliability of new magnetic resonance imaging lesion counts by clinicians in a multiple sclerosis specialty clinic.
Schirmer et al investigate the expression of CD161 (KLRB1) and CCR6 on human γδd T cells in blood and cerebrospinal fluid of patients with a clinically isolated syndrome and multiple sclerosis in relapse.
Yeo and colleagues conducted a longitudinal cohort study of consecutive intravenous tissue plasminogen activator-treated patients with acute ischemic stroke (AIS) from 2007 through 2010 to examine the timing and impact of recanalization on functional outcomes in AIS.
Fields and coworkers used a retrospective medical record review to analyze hospital-onset seizure patterns, medication use, and outcomes in 218 patients admitted to the hospital for nonseizure reasons.
Van Langenhove and colleagues conducted a study to characterize patients with frontotemporal lobar degeneration (FTLD) with a repeat expansion mutation in the gene C9orf72, and to determine whether there are differences in the clinical presentation compared with FTLD carriers of a mutation in GRN or MAPT or with patients with FTLD without mutation.
In a prospective, population-based, cohort study of 2719 participants with a median 4.0 years of follow-up, Roberts and coworkers investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment.
Richard et al evaluate the association of late-life depression with mild cognitive impairment and dementia in a multiethnic community cohort including 2160 individuals aged 65 years or older.
In a case report, Kieseier and colleagues discuss the clinical and paraclinical effects of tocilizumab in a patient with neuromyelitis optica.
In a retrospective case series, Ayzenberg et al report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica.
Boster et al describe the clinical, radiological, and histopathological features of a fatal case of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab.
Walker et al review evidence that β-amyloid and tau proteins, which aggregate to form senile plaques and neurofibrillary tangles, respectively, are induced to misfold and self-assemble by templated conformational change. They describe the potential role of protein seeding in the instigation and spread of the cardinal lesions that characterize Alzheimer disease.
Scott et al conducted a review of the literature to identify data on the usefulness of brain and body imaging, serum and cerebrospinal fluid studies, ophthalmologic examination, and tissue biopsy in the diagnosis of central nervous system (CNS) lymphoma.
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