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April 2019 - July 1959

Decade

Year

Issue

March 2013, Vol 70, No. 3, Pages 288-415

In This Issue of JAMA Neurology

In This Issue of JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2013;70(3):293-294. doi:10.1001/jamaneurol.2013.1610
Editorial

Apolipoprotein E, Neurodegeneration, and Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2013;70(3):299-300. doi:10.1001/jamaneurol.2013.726

Cognitive Dysfunction and Contact Sports

Abstract Full Text
JAMA Neurol. 2013;70(3):301-302. doi:10.1001/jamaneurol.2013.1930
Original Contribution

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2013;70(3):320-325. doi:10.1001/2013.jamaneurol.286

In a cross-sectional comparison of measurements of cerebral glucose metabolism and brain volume in cognitively normal, late-middle-aged persons, Protas and coauthors characterize and compare the measurements so as to distinguish these persons with 2, 1, or 0 copies of the APOE ϵ4 allele, reflecting 3 levels of risk for late-onset Alzheimer disease. See editorial by Jagust.

Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players: A Cross-sectional Study

Abstract Full Text
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JAMA Neurol. 2013;70(3):326-335. doi:10.1001/2013.jamaneurol.340

Hart et al assessed the prevalence of cognitive impairment and depression in a sample of former National Football League (NFL) players and identified neuroimaging correlates of these dysfunctions. See also the editorial by Diaz-Arrastia.

Reliability of Classifying Multiple Sclerosis Disease Activity Using Magnetic Resonance Imaging in a Multiple Sclerosis Clinic

Abstract Full Text
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JAMA Neurol. 2013;70(3):338-344. doi:10.1001/2013.jamaneurol.211

In an observational study, Erbayat Altay et al assess the reliability of new magnetic resonance imaging lesion counts by clinicians in a multiple sclerosis specialty clinic.

Enriched CD161high CCR6+ γδ T Cells in the Cerebrospinal Fluid of Patients With Multiple Sclerosis

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JAMA Neurol. 2013;70(3):345-351. doi:10.1001/2013.jamaneurol.409

Schirmer et al investigate the expression of CD161 (KLRB1) and CCR6 on human γδd T cells in blood and cerebrospinal fluid of patients with a clinically isolated syndrome and multiple sclerosis in relapse.

Timing of Recanalization After Intravenous Thrombolysis and Functional Outcomes After Acute Ischemic Stroke

Abstract Full Text
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JAMA Neurol. 2013;70(3):353-358. doi:10.1001/2013.jamaneurol.547

Yeo and colleagues conducted a longitudinal cohort study of consecutive intravenous tissue plasminogen activator-treated patients with acute ischemic stroke (AIS) from 2007 through 2010 to examine the timing and impact of recanalization on functional outcomes in AIS.

Hospital-Onset Seizures: An Inpatient Study

Abstract Full Text
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JAMA Neurol. 2013;70(3):360-364. doi:10.1001/2013.jamaneurol.337

Fields and coworkers used a retrospective medical record review to analyze hospital-onset seizure patterns, medication use, and outcomes in 218 patients admitted to the hospital for nonseizure reasons.

Distinct Clinical Characteristics of C9orf72 Expansion Carriers Compared With GRN, MAPT, and Nonmutation Carriers in a Flanders-Belgian FTLD Cohort

Abstract Full Text
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JAMA Neurol. 2013;70(3):365-373. doi:10.1001/2013.jamaneurol.181

Van Langenhove and colleagues conducted a study to characterize patients with frontotemporal lobar degeneration (FTLD) with a repeat expansion mutation in the gene C9orf72, and to determine whether there are differences in the clinical presentation compared with FTLD carriers of a mutation in GRN or MAPT or with patients with FTLD without mutation.

Cardiac Disease Associated With Increased Risk of Nonamnestic Cognitive Impairment: Stronger Effect on Women

Abstract Full Text
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JAMA Neurol. 2013;70(3):374-382. doi:10.1001/jamaneurol.2013.607

In a prospective, population-based, cohort study of 2719 participants with a median 4.0 years of follow-up, Roberts and coworkers investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment.

Late-Life Depression, Mild Cognitive Impairment, and Dementia

Abstract Full Text
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JAMA Neurol. 2013;70(3):383-389. doi:10.1001/jamaneurol.2013.603

Richard et al evaluate the association of late-life depression with mild cognitive impairment and dementia in a multiethnic community cohort including 2160 individuals aged 65 years or older.

Images in Neurology

Dystextia: Acute Stroke in the Modern Age

Abstract Full Text
JAMA Neurol. 2013;70(3):404. doi:10.1001/jamaneurol.2013.604

Intra-arterial Thrombolysis of Acute Cerebral Vascular Occlusion During Endovascular Treatment of Adjacent Aneurysms at the Internal Carotid Artery

Abstract Full Text
JAMA Neurol. 2013;70(3):406-407. doi:10.1001/jamaneurol.2013.602

Diaschisis as the Presenting Feature in Sporadic Creutzfeldt-Jakob Disease

Abstract Full Text
JAMA Neurol. 2013;70(3):408-409. doi:10.1001/jamaneurol.2013.590

In Vivo Demonstration of Homonymous Hemimacular Loss of Retinal Ganglion Cells Due to a Thalamic Lesion Using Optical Coherence Tomography

Abstract Full Text
JAMA Neurol. 2013;70(3):410-411. doi:10.1001/jamaneurol.2013.605
Observation

Disease Amelioration With Tocilizumab in a Treatment-Resistant Patient With Neuromyelitis Optica: Implication for Cellular Immune Responses

Abstract Full Text
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JAMA Neurol. 2013;70(3):390-393. doi:10.1001/jamaneurol.2013.668

In a case report, Kieseier and colleagues discuss the clinical and paraclinical effects of tocilizumab in a patient with neuromyelitis optica.

Interleukin 6 Receptor Blockade in Patients With Neuromyelitis Optica Nonresponsive to Anti-CD20 Therapy

Abstract Full Text
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JAMA Neurol. 2013;70(3):394-397. doi:10.1001/jamaneurol.2013.1246

In a retrospective case series, Ayzenberg et al report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica.

Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab

Abstract Full Text
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JAMA Neurol. 2013;70(3):398-402. doi:10.1001/jamaneurol.2013.1960

Boster et al describe the clinical, radiological, and histopathological features of a fatal case of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with natalizumab.

Neurological Review

Mechanisms of Protein Seeding in Neurodegenerative Diseases

Abstract Full Text
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JAMA Neurol. 2013;70(3):304-310. doi:10.1001/jamaneurol.2013.1453

Walker et al review evidence that β-amyloid and tau proteins, which aggregate to form senile plaques and neurofibrillary tangles, respectively, are induced to misfold and self-assemble by templated conformational change. They describe the potential role of protein seeding in the instigation and spread of the cardinal lesions that characterize Alzheimer disease.

A Systematic Approach to the Diagnosis of Suspected Central Nervous System Lymphoma

Abstract Full Text
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JAMA Neurol. 2013;70(3):311-319. doi:10.1001/jamaneurol.2013.606

Scott et al conducted a review of the literature to identify data on the usefulness of brain and body imaging, serum and cerebrospinal fluid studies, ophthalmologic examination, and tissue biopsy in the diagnosis of central nervous system (CNS) lymphoma.

Correspondence

Elderly Individuals With FTLD

Abstract Full Text
JAMA Neurol. 2013;70(3):412-413. doi:10.1001/2013.jamaneurol.552

Elderly Individuals With FTLD

Abstract Full Text
JAMA Neurol. 2013;70(3):412-413. doi:10.1001/jamaneurol.2013.1649

Association Between Angiotensin Receptor Blockers and Better Cognitive Outcome: Urgent Need for a Randomized Trial

Abstract Full Text
JAMA Neurol. 2013;70(3):413-414. doi:10.1001/jamaneurol.2013.1804

Parkinsonism and Cancer

Abstract Full Text
JAMA Neurol. 2013;70(3):414-415. doi:10.1001/jamaneurol.2013.1283

Alzheimer Pathology and Angiotension Receptor Blockers

Abstract Full Text
JAMA Neurol. 2013;70(3):414. doi:10.1001/jamaneurol.2013.1464

Alzheimer Pathology and Angiotension Receptor Blockers

Abstract Full Text
JAMA Neurol. 2013;70(3):414. doi:10.1001/jamaneurol.2013.1689
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