To define the incidence of and explore risk factors for seizures and epilepsy in children with spontaneous intracerebral hemorrhage (ICH), Beslow and colleagues conducted a prospective cohort study of 73 pediatric subjects with spontaneous ICH, including 20 perinatal and 53 childhood subjects. Heyer and Roach provide a related editorial.
Provenzano and colleagues collected data from the Alzheimer Disease Neuroimaging Initiative public database to determine the impact of white matter hyperintensities (WMHs) and Pittsburgh Compound B positron-emission tomography–derived amyloid positivity on the clinical expression of Alzheimer disease. Karen M. Rodrigue, PhD, provides a related editorial.
Irwin et al examine evidence for human-to-human transmission of Alzheimer disease, Parkinson disease, and related neurodegenerative disease–associated proteins in cadaveric human growth hormone recipients.
In a retrospective study, Kornek and coauthors report the use of natalizumab therapy for highly active pediatric multiple sclerosis.
In a retrospective medical record review, Loureiro et al describe the clinical, genetic, and epidemiological features of Portuguese families with autosomal dominant hereditary spastic paraplegias.
Marchant and coauthors examine the relationship between neuroimaging measures of vascular brain injury and brain β-amyloid deposition and their associations with cognition in elderly individuals.
Zlokovic reviews β-amyloid–independent and β-amyloid–dependent cerebrovascular effects of apolipoprotein E as well as isoform-specific interactions of apolipoprotein E with low-density lipoprotein receptor-related protein 1 on brain vascular cells.
Navalkele et al describe a man with progressive asymmetric leg pain and weakness, enhancement of the cauda equina and leptomeninges of the lower spinal cord, elevated protein concentration, and lymphocytic pleocytosis. He had normal cytological findings, elevated IgG synthesis, and elevated antibody titers to varicella-zoster virus. Over time, he worsened, developed cranial neuropathies, and died.
Damásio et al describe a pediatric case of progressive encephalomyelitis with rigidity and myoclonus (PERM) with glycine receptor alpha 1 antibodies.
Ohyama et al describe the clinical features and nerve biopsy findings of a patient with IgG4-related disease who presented with neuropathy in the extremities.
Höftberger et al describe the second patient with cerebellitis and Homer-3 antibodies and report a novel, highly specific immunoblot assay.
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