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August 2020 - July 1959

Decade

Year

Issue

July 2013, Vol 70, No. 7, Pages 817-944

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2013;70(7):817-819. doi:10.1001/jamaneurol.2013.2872
Viewpoint

Inpatient Neurologic Care: Continued Challenges of a Neurohospitalist Model

Abstract Full Text
JAMA Neurol. 2013;70(7):825-826. doi:10.1001/jamaneurol.2013.2968
Editorial

The New Look of JAMA Neurology!

Abstract Full Text
JAMA Neurol. 2013;70(7):827. doi:10.1001/jamaneurol.2013.3566

Emergency Management of Acute Ischemic Stroke: The Evolving Roles of Intravenous and Endovascular Therapies

Abstract Full Text
JAMA Neurol. 2013;70(7):828-830. doi:10.1001/jamaneurol.2013.2948
Original Investigation

Comparison of Final Infarct Volumes in Patients Who Received Endovascular Therapy or Intravenous Thrombolysis for Acute Intracranial Large-Vessel Occlusions

Abstract Full Text
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JAMA Neurol. 2013;70(7):831-836. doi:10.1001/jamaneurol.2013.413

In a retrospective cohort study, Rangaraju and coauthors assess whether patients with intracranial large-vessel occlusions who received intra-arterial therapy have smaller final infarct volumes than patients who received either intravenous tissue plasminogen activator therapy or no reperfusion therapy. See the Article by Adams and Froehler.

Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): An Observational Study

Abstract Full Text
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JAMA Neurol. 2013;70(7):837-844. doi:10.1001/jamaneurol.2013.406

In an observational study based on Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR) data during the period from 2002 to 2011, Ahmed and coauthors compare outcomes of patients who were treated within 4.5 to 6 hours or within 3 to 4.5 hours of the onset of an ischemic stroke with outcomes of patients who were treated within 3 hours in the SITS-ISTR.

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Abstract Full Text
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JAMA Neurol. 2013;70(7):845-851. doi:10.1001/jamaneurol.2013.38

Palacios et al studied functional magnetic resonance imaging abnormalities in signal amplitude and brain connectivity at rest and their relationship to cognitive outcome in patients with chronic and severe traumatic axonal injury.

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations

Abstract Full Text
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JAMA Neurol. 2013;70(7):852-858. doi:10.1001/jamaneurol.2013.1274

To determine if patients having PD with vs without GBA mutations differ in clinical phenotype or plasma protein expression, Chahine et al performed a case-control study. Clinical characteristics were compared between groups, and biochemical profiling of 40 plasma proteins was performed to identify proteins that differed in expression between groups.

Incidence and Pathology of Synucleinopathies and Tauopathies Related to Parkinsonism

Abstract Full Text
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JAMA Neurol. 2013;70(7):859-866. doi:10.1001/jamaneurol.2013.114

Savica et al investigate the incidence and distribution of specific types of parkinsonism and related proteinopathies in the general population.

Reduced Prevalence of Cognitive Impairment in Families With Exceptional Longevity

Abstract Full Text
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JAMA Neurol. 2013;70(7):867-874. doi:10.1001/jamaneurol.2013.1959

Cosentino et al determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease.

Genetic Analysis of Inherited Leukodystrophies: Genotype-Phenotype Correlations in the CSF1R Gene

Abstract Full Text
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JAMA Neurol. 2013;70(7):875-882. doi:10.1001/jamaneurol.2013.698

Guerreiro et al sequenced a large cohort of adult-onset leukodystrophy cases to better understand the genetic role of mutations in CSF1R.

Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging

Abstract Full Text
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JAMA Neurol. 2013;70(7):883-890. doi:10.1001/jamaneurol.2013.1425

Friedman et al used brain magnetic resonance spectroscopy to examine the neurochemical effects of growth hormone–releasing hormone in adults with mild cognitive impairment and in healthy older adults.

Nocturnal Rapid Eye Movement Sleep Latency for Identifying Patients With Narcolepsy/Hypocretin Deficiency

Abstract Full Text
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JAMA Neurol. 2013;70(7):891-902. doi:10.1001/jamaneurol.2013.1589

Andlauer et al determine the diagnostic accuracy and clinical utility of nocturnal rapid eye movement sleep latency measures in narcolepsy/hypocretin deficiency.

Cross-sectional and Longitudinal Analysis of the Relationship Between Aβ Deposition, Cortical Thickness, and Memory in Cognitively Unimpaired Individuals and in Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2013;70(7):903-911. doi:10.1001/jamaneurol.2013.1062

Doré et al investigated the topographical relationship of Aβ deposition, gray matter atrophy, and memory impairment in asymptomatic individuals with Alzheimer disease pathology as assessed by Pittsburgh compound B positron emission tomography.

Case Report/Case Series

Does a Positive Pittsburgh Compound B Scan in a Patient With Dementia Equal Alzheimer Disease?

Abstract Full Text
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JAMA Neurol. 2013;70(7):912-914. doi:10.1001/jamaneurol.2013.420

Ducharme et al investigate whether a positive Pittsburgh Compound B scan is specific for the diagnosis of Alzheimer disease or can be secondary to cerebral amyloid angiopathy alone.

Fatal B-cell Lymphoma Following Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids

Abstract Full Text
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JAMA Neurol. 2013;70(7):915-918. doi:10.1001/jamaneurol.2013.2016

De Graaff and coauthors report on a well-documented patient who presented with clinical, radiological, and pathological characteristics of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) and who had an unfavorable outcome.

Autoantibodies in Sporadic Creutzfeldt-Jakob Disease

Abstract Full Text
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JAMA Neurol. 2013;70(7):919-922. doi:10.1001/jamaneurol.2013.2077

Angus-Leppan et al illustrate potential difficulties in differentiating autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.

Review

Diagnosis of Pompe Disease: Muscle Biopsy vs Blood-Based Assays

Abstract Full Text
JAMA Neurol. 2013;70(7):923-927. doi:10.1001/2013.jamaneurol.486

Vissing et al evaluate the use of muscle biopsy vs blood-based enzymatic assays in the diagnosis of late-onset Pompe disease.

Clinical Implications of Basic Neuroscience Research

TRIM Proteins in Therapeutic Membrane Repair of Muscular Dystrophy

Abstract Full Text
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JAMA Neurol. 2013;70(7):928-931. doi:10.1001/jamaneurol.2013.469

Alloush and Weisleder reviewed the literature on membrane repair in the past decade, considering recent discoveries of genes associated with the membrane repair process in skeletal muscle and the implications for treatment of muscular dystrophy.

Clinical Pathological Conference

Blind and Confused

Abstract Full Text
JAMA Neurol. 2013;70(7):932-936. doi:10.1001/jamaneurol.2013.3105

Sharma and colleagues present the case of a 62-year-old man who developed confusion and was diagnosed as having encephalitis, but no specific etiology was found.

Images in Neurology

Fulminant Idiopathic Intracranial Hypertension

Abstract Full Text
JAMA Neurol. 2013;70(7):937-938. doi:10.1001/jamaneurol.2013.1951

Cortical Vein Air Emboli With Gyriform Infarcts

Abstract Full Text
JAMA Neurol. 2013;70(7):939-940. doi:10.1001/jamaneurol.2013.1949
Comment & Response

Diagnosis of Intravascular Lymphoma—Reply

Abstract Full Text
JAMA Neurol. 2013;70(7):941-942. doi:10.1001/jamaneurol.2013.2973

Diagnosis of Intravascular Lymphoma

Abstract Full Text
JAMA Neurol. 2013;70(7):941. doi:10.1001/jamaneurol.2013.307
Book Reviews

Review of Aminoff’s Electrodiagnosis in Clinical Neurology, 6th ed

Abstract Full Text
JAMA Neurol. 2013;70(7):943. doi:10.1001/jamaneurol.2013.2822

Review of Intraoperative Neurophysiologic Monitoring, 3rd ed

Abstract Full Text
JAMA Neurol. 2013;70(7):943-944. doi:10.1001/jamaneurol.2013.2850
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2013;70(7):820. doi:10.1001/jamaneurol.2013.2870
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