Walczak et al assess the safety and efficacy of transdermally applied myelin peptides in patients with relapsing-remitting multiple sclerosis.
Kim et al reported the results of rituximab treatment in patients with relapsing neuromyelitis optica or neuromyelitis optica spectrum disorder for a median of 60 months. See the Article by McKeon and Pittock.
Matiello and colleagues evaluate tissue-specific messenger RNA and protein expression and supramolecular aggregation of aquaporin 4 (AQP4) in mouse, rat, and human tissues in an effort to understand the predilection for optic nerve and spinal cord pathologic changes in neuromyelitis optica (NMO).
Prabhakaran et al evaluate the impact that a citywide policy recommending prehospital triage of patients with suspected stroke to the nearest primary stroke center had on intravenous tissue plasminogen activator (tPA) use in Chicago, Illinois.
Kayser et al determine the frequency, symptoms, and outcome of isolated psychiatric episodes in a cohort of patients with anti–N-methyl-d-aspartate (NMDAR) encephalitis.
Chang et al investigate the characteristics and potential pathogenicity of glutamic acid decarboxylase autoantibodies in patients with stiff person syndrome and related disorders.
Shulman et al investigate whether Alzheimer disease susceptibility loci from genome-wide association studies affect neuritic plaque pathology and additionally aim to identify novel risk loci for this trait.
Vossel et al describe common clinical characteristics and treatment outcomes of patients with amnestic mild cognitive impairment or early AD who also have epilepsy or subclinical epileptiform activity.
Thambisetty et al investigate the association between glucose intolerance and insulin resistance and in vivo brain β-amyloid burden, measured with carbon 11–labeled Pittsburgh Compound B and pathological features of Alzheimer disease at autopsy.
In a case series of 3 patients with acute ischemic stroke who later received a diagnosis of fungal meningitis attributed to epidural injections of contaminated methylprednisolone acetate, Kleinfeld and coauthors describe how these patients presented with ischemic infarction in differing vascular distributions.
Mendelian forms of complex I deficiency are usually associated with fatal infantile encephalomyopathy. Application of “MitoExome” sequencing allowed Garone and coauthors to reveal an unusual clinical variant of complex I deficiency due to a novel homozygous mutation in ACAD9. The patient had an infantile-onset but slowly progressive encephalomyopathy and responded favorably to riboflavin therapy.
Simpson and colleagues reported the unusual clinical and molecular-neuropathological profile in a case of Gerstmann-Sträussler-Scheinker (GSS) disease associated with a novel prion protein gene (PRNP) mutation.
Using 15 years’ experience with parkin-associated Parkinson disease, Grünewald and colleagues evaluate type, quality, and quantity of genetic and phenotypic data and elucidate clinical or genetic features impacting genetic testing and counseling.
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