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July 2019 - July 1959

Decade

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Issue

January 2014, Vol 71, No. 1, Pages 2-120

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(1):2-3. doi:10.1001/jamaneurol.2013.4126
Viewpoint

From Genome-Wide Association Studies to Next-Generation Sequencing: Lessons From the Past and Planning for the Future

Abstract Full Text
JAMA Neurol. 2014;71(1):5-6. doi:10.1001/jamaneurol.2013.3682
Editorial

APOE Genotype and Brain Development

Abstract Full Text
JAMA Neurol. 2014;71(1):7-8. doi:10.1001/jamaneurol.2013.5200

Beyond the Basal Ganglia: Cortical Effects of Deep Brain Stimulation

Abstract Full Text
JAMA Neurol. 2014;71(1):8-10. doi:10.1001/jamaneurol.2013.4643
Original Investigation

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease: A Cross-sectional Imaging Study

Abstract Full Text
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JAMA Neurol. 2014;71(1):11-22. doi:10.1001/jamaneurol.2013.4544

Dean et al compare magnetic resonance imaging measurements of white matter myelin water fraction and gray matter volume in healthy infant carriers and noncarriers of the APOE ε4 allele, the major susceptibility gene for late-onset Alzheimer disease. See related Editorial by Growdon and Hyman.

Amyloid Imaging With Carbon 11–Labeled Pittsburgh Compound B for Traumatic Brain Injury

Abstract Full Text
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JAMA Neurol. 2014;71(1):23-31. doi:10.1001/jamaneurol.2013.4847

Hong and coauthors image amyloid deposition in patients with traumatic brain injury using carbon 11–labeled Pittsburgh Compound B positron emission tomography and validate these findings using hydrogen 3–labeled Pittsburgh Compound B autoradiography and immunocytochemistry on autopsy-acquired tissue.

Biochemical Characterization of Patients With In-Frame or Out-of-Frame DMD Deletions Pertinent to Exon 44 or 45 Skipping

Abstract Full Text
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JAMA Neurol. 2014;71(1):32-40. doi:10.1001/jamaneurol.2013.4908

Anthony et al quantify dystrophin messenger RNA and protein expression in patients with DMD deletions treatable by, or mimicking, exon 44 or 45 skipping.

Branching Enzyme Deficiency: Expanding the Clinical Spectrum

Abstract Full Text
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JAMA Neurol. 2014;71(1):41-47. doi:10.1001/jamaneurol.2013.4888

To describe the clinical presentation and progression of a new intermediate variant of glycogen branching enzyme deficiency, Paradas et al performed a clinical, biochemical, morphological, and molecular study of 2 patients with adult acute onset of neurological signs initially diagnosed as multiple sclerosis. Genotype-phenotype correlations are discussed.

Aquaporin 4 IgG Serostatus and Outcome in Recurrent Longitudinally Extensive Transverse Myelitis

Abstract Full Text
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JAMA Neurol. 2014;71(1):48-54. doi:10.1001/jamaneurol.2013.5055

Jiao et al determined the aquaporin 4 (AQP4) IgG detection rate using recombinant human APQ4–based assays in sequential serum specimens collected from patients with recurrent longitudinally extensive transverse myelitis (rLETM) categorized as negative by indirect immunofluorescence assay and defined the clinical characteristics and motor disability outcomes in AQP4-IgG–positive rLETM.

Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia: The Framingham Heart Study

Abstract Full Text
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JAMA Neurol. 2014;71(1):55-61. doi:10.1001/jamaneurol.2013.4781

Weinstein and colleagues conducted a community-based, prospective cohort study to examine whether higher serum brain-derived neurotrophic factor (BDNF) levels in cognitively healthy adults protect against the future risk for dementia and Alzheimer disease and to identify potential modifiers of this association.

Cognitive and Motor Function in Long-Duration PARKIN-Associated Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2014;71(1):62-67. doi:10.1001/jamaneurol.2013.4498

In a cross-sectional study of 44 participants with early-onset PD of long duration, Alcalay and coauthors assessed cognitive and motor performances, comparing homozygotes and compound heterozygotes who carry 2 PARKIN mutations with noncarriers.

Clinical Worsening in Reversible Cerebral Vasoconstriction Syndrome

Abstract Full Text
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JAMA Neurol. 2014;71(1):68-73. doi:10.1001/jamaneurol.2013.4639

Katz et al define the frequency, timing, and consequences of clinical worsening in patients with diagnosis of RCVS.

Determination of Neuronal Antibodies in Suspected and Definite Creutzfeldt-Jakob Disease

Abstract Full Text
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JAMA Neurol. 2014;71(1):74-78. doi:10.1001/jamaneurol.2013.4857

Grau-Rivera et al determine the frequency of antibodies against neuronal surface antigens in the cerebrospinal fluid of patients with suspected as well as pathologically confirmed Creutzfeldt-Jakob disease.

Case Report/Case Series

Limbic Encephalitis Associated With Anti–Voltage-Gated Potassium Channel Complex Antibodies Mimicking Creutzfeldt-Jakob Disease

Abstract Full Text
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JAMA Neurol. 2014;71(1):79-82. doi:10.1001/jamaneurol.2013.5179

Yoo and Hirsch present the case of a 58-year-old man who had a rapid onset of progressive confusion, twitching of the face and hand, and abnormal basal ganglia detected by magnetic resonance imaging, which were initially diagnosed as Creutzfeldt-Jakob disease. Faciobrachial dystonic seizures had been misdiagnosed as myoclonus. Treatment led to a complete resolution of his symptoms.

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease: Two Case Reports

Abstract Full Text
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JAMA Neurol. 2014;71(1):83-87. doi:10.1001/jamaneurol.2013.4749

Kefalopoulou et al report the very long-term outcome of 2 patients with Parkinson disease who received human fetal ventral mesencephalic neural grafts.

Severe Axial Myopathy in McArdle Disease

Abstract Full Text
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JAMA Neurol. 2014;71(1):88-90. doi:10.1001/jamaneurol.2013.3209

Witting et al describe a 61-year-old man with a highly atypical presentation of McArdle disease with severe paraspinal wasting and weakness.

Review

Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2014;71(1):91-99. doi:10.1001/jamaneurol.2013.4684

Watzlawickand colleagues conducted a systematic review and meta-analysis of RhoA/Rho-associated coiled-coil containing protein kinase blocking approaches to (1) analyze the impact of bias that may lead to inflated effect sizes and (2) determine the normalized effect size of functional locomotor recovery after experimental thoracic spinal cord injury.

Clinical Implications of Basic Neuroscience Research

Cortical Effects of Deep Brain Stimulation: Implications for Pathogenesis and Treatment of Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2014;71(1):100-103. doi:10.1001/jamaneurol.2013.4221

Recent studies in both human and animal models strongly suggest that activity in the cortex, especially in motor cortical areas, is directly altered by deep brain stimulation by signals traveling in an antidromic fashion from the subthalamic nucleus. Li and coauthors discuss the evidence for this proposition. See the editorial by Miocinovic.

Clinical Pathologic Conference

Progressive Parkinsonism, Balance Difficulties, and Supranuclear Gaze Palsy

Abstract Full Text
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JAMA Neurol. 2014;71(1):104-107. doi:10.1001/jamaneurol.2013.5149

Erroand colleagues describe a 76-year-old man who presented with a 4-year history of a progressive parkinsonian syndrome.

Images in Neurology

Reversible Vigabatrin-Induced Life-Threatening Encephalopathy

Abstract Full Text
JAMA Neurol. 2014;71(1):108-109. doi:10.1001/jamaneurol.2013.1858

Diffusely Infiltrating Central Nervous System Lymphoma Involving the Brainstem in an Immune-Competent Patient

Abstract Full Text
JAMA Neurol. 2014;71(1):110-111. doi:10.1001/jamaneurol.2013.1578
Comment & Response

Neurologists as Physician-Scientists

Abstract Full Text
JAMA Neurol. 2014;71(1):113. doi:10.1001/jamaneurol.2013.4813
Book and Media Review

Review of Alfalfa to Ivy: Memoir of a Harvard Medical School Dean

Abstract Full Text
JAMA Neurol. 2014;71(1):115-116. doi:10.1001/jamaneurol.2013.5169
Peer Reviewers List

JAMA Neurology Peer Reviewers in 2013

Abstract Full Text
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JAMA Neurol. 2014;71(1):118-120. doi:10.1001/jamaneurol.2013.5204
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(1):4. doi:10.1001/jamaneurol.2013.4127
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