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September 2021 - July 1959

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October 2014, Vol 71, No. 10, Pages 1203-1329

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(10):1203. doi:10.1001/jamaneurol.2013.4171
Viewpoint

Lyme Disease: Authentic Imitator or Wishful Imitation?

Abstract Full Text
has audio
JAMA Neurol. 2014;71(10):1209-1210. doi:10.1001/jamaneurol.2014.1193
Editorial

Blood Pressure and the Prevention of Cognitive Impairment

Abstract Full Text
JAMA Neurol. 2014;71(10):1211-1213. doi:10.1001/jamaneurol.2014.2014

Is Apolipoprotein E Required for Cognitive Function in Humans?Implications for Alzheimer Drug Development

Abstract Full Text
JAMA Neurol. 2014;71(10):1213-1215. doi:10.1001/jamaneurol.2014.2013

Clinical Exome Sequencing: The New Standard in Genetic Diagnosis

Abstract Full Text
JAMA Neurol. 2014;71(10):1215-1216. doi:10.1001/jamaneurol.2014.2015
Original Investigation

Midlife Hypertension and 20-Year Cognitive Change: The Atherosclerosis Risk in Communities Neurocognitive Study

Abstract Full Text
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JAMA Neurol. 2014;71(10):1218-1227. doi:10.1001/jamaneurol.2014.1646

Gottesman et al evaluate the association between midlife (48-67 years of age) hypertension and the 20-year change in cognitive performance among the Atherosclerosis Risk in Communities cohort. See also the editorial by Gorelick.

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

Abstract Full Text
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JAMA Neurol. 2014;71(10):1228-1236. doi:10.1001/jamaneurol.2014.2011

Mak et al describe a man with extensive tuberous and morbilliform cutaneous xanthomas and exceptionally severe dysbetalipoproteinemia. They aimed to discover the molecular basis of the disorder and to determine the effects of complete absence of apolipoprotein E on neurocognitive and visual function and on lipoprotein metabolism. Lane-Donovan and Herz provide commentary in a related editorial.

Exome Sequencing in the Clinical Diagnosis of Sporadic or Familial Cerebellar Ataxia

Abstract Full Text
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JAMA Neurol. 2014;71(10):1237-1246. doi:10.1001/jamaneurol.2014.1944

Fogel and colleagues investigated the contribution of genetic disease in a population of patients with predominantly adult- and sporadic-onset cerebellar ataxia. Gomez and Das provided a related Article .

Effect of Leukocyte Telomere Length on Total and Regional Brain Volumes in a Large Population-Based Cohort

Abstract Full Text
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JAMA Neurol. 2014;71(10):1247-1254. doi:10.1001/jamaneurol.2014.1926

King et al determine if peripheral blood telomere length is associated with brain volume. Peripheral blood leukocyte telomere length and brain volumes were measured among 1950 individuals (median age, 50 years) in the Dallas Heart Study. Global and 48 regional brain volumes were assessed from the automated analysis of magnetic resonance imaging.

Triheptanoin for Glucose Transporter Type I Deficiency (G1D): Modulation of Human Ictogenesis, Cerebral Metabolic Rate, and Cognitive Indices by a Food Supplement

Abstract Full Text
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JAMA Neurol. 2014;71(10):1255-1265. doi:10.1001/jamaneurol.2014.1584

Pascual et al evaluate the use of triheptanoin in the treatment of glucose transporter type I deficiency in a case series including 14 patients.

Structural Growth Trajectories and Rates of Change in the First 3 Months of Infant Brain Development

Abstract Full Text
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JAMA Neurol. 2014;71(10):1266-1274. doi:10.1001/jamaneurol.2014.1638

Holland et al assessed structural growth trajectories and rates of change in the whole brain and regions of interest in infants during the first 3 months after birth.

Impaired Cerebrovascular Reactivity in Multiple Sclerosis

Abstract Full Text
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JAMA Neurol. 2014;71(10):1275-1281. doi:10.1001/jamaneurol.2014.1668

Marshall and coauthors use hypercapnic perfusion magnetic resonance imaging to assess cerebrovascular reactivity impairment in patients with multiple sclerosis.

Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42: A Cross-Validation Study Against Amyloid Positron Emission Tomography

Abstract Full Text
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JAMA Neurol. 2014;71(10):1282-1289. doi:10.1001/jamaneurol.2014.1358

Palmqvist and colleagues studied whether cerebrospinal fluid (CSF) biomarkers, analyzed consecutively in routine clinical practice during 2 years, can predict cortical β-amyloid (Aβ) deposition, and aimed to establish a threshold for Aβ42 abnormality.

Effect of Advancing Age on Outcomes of Deep Brain Stimulation for Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2014;71(10):1290-1295. doi:10.1001/jamaneurol.2014.1272

DeLong et al suggest that age alone should not be a primary exclusion factor for determining candidacy for deep brain stimulation. Instead, a clear focus on patients with medication-refractory and difficult to control on-off fluctuations with preserved cognition, regardless of age, may allow for an expansion of the traditional therapeutic window.

Case Report/Case Series

Autologous Stem Cell Transplantation for Stiff Person Syndrome: Two Cases From the Ottawa Blood and Marrow Transplant Program

Abstract Full Text
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JAMA Neurol. 2014;71(10):1296-1299. doi:10.1001/jamaneurol.2014.1297

Sanders et al report 2 cases of severe stiff person syndrome treated with autologous hematopoietic cell transplantation, a novel therapy for this disease.

Episodic Bradycardia as Neurocardiac Prodrome to Voltage-Gated Potassium Channel Complex/Leucine-Rich, Glioma Inactivated 1 Antibody Encephalitis

Abstract Full Text
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JAMA Neurol. 2014;71(10):1300-1304. doi:10.1001/jamaneurol.2014.1234

Naasan and colleagues describe a novel neurocardiac prodrome of voltage-gated potassium channel complex antibody/leucine-glioma rich inactivated 1 encephalitis.

Autosomal Recessive Cerebellar Ataxia Type 3 Due to ANO10 Mutations: Delineation and Genotype-Phenotype Correlation Study

Abstract Full Text
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JAMA Neurol. 2014;71(10):1305-1310. doi:10.1001/jamaneurol.2014.193

ANO10 mutations have been reported to cause a novel form of autosomal recessive cerebellar ataxia (ARCA). Renaud and coauthors report 9 ataxic patients carrying 8 novel ANO10 mutations to improve the delineation of this form of ARCA and provide genotype-phenotype correlation.

Review

Translational Research in Acute Central Nervous System Injury: Lessons Learned and the Future

Abstract Full Text
JAMA Neurol. 2014;71(10):1311-1318. doi:10.1001/jamaneurol.2014.1238

Warner and coauthors chronicle the evolution of preclinical research designed to provide therapeutic interventions.

Clinical Implications of Basic Neuroscience Research

IDH Mutation in Glioma: New Insights and Promises for the Future

Abstract Full Text
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JAMA Neurol. 2014;71(10):1319-1325. doi:10.1001/jamaneurol.2014.1205

Turkalp et al review the role of isocitrate dehydrogenase (IDH) in normal physiology and describe aberrations in the IDH pathway that are associated with gliomagenesis, and they review recent work examining the effect of IDH-targeted therapy in cancers harboring IDH mutation and determine how this work has expanded our understanding of the role of IDH in the development and progression of glioma.

Comment & Response

Risk Index and Thrombolytic Treatment in Acute Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2014;71(10):1326. doi:10.1001/jamaneurol.2014.2294

Risk Index and Thrombolytic Treatment in Acute Ischemic Stroke—Reply

Abstract Full Text
JAMA Neurol. 2014;71(10):1326. doi:10.1001/jamaneurol.2014.2297

Treating Idiopathic Intracranial Hypertension

Abstract Full Text
JAMA Neurol. 2014;71(10):1326-1327. doi:10.1001/jamaneurol.2014.2360

Treating Idiopathic Intracranial Hypertension—Reply

Abstract Full Text
JAMA Neurol. 2014;71(10):1327-1328. doi:10.1001/jamaneurol.2014.2363
Correction

Incorrect Information in Tables and Figure Caption

Abstract Full Text
free access
JAMA Neurol. 2014;71(10):1328. doi:10.1001/jamaneurol.2014.2914
Book and Media Review

Review of Neuropsychiatry and Cognitive Changes in Parkinson’s Disease and Related Movement Disorders

Abstract Full Text
JAMA Neurol. 2014;71(10):1329. doi:10.1001/jamaneurol.2014.1868
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(10):1204. doi:10.1001/jamaneurol.2013.4172
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