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December 2014, Vol 71, No. 12, Pages 1467-1580

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(12):1467. doi:10.1001/jamaneurol.2013.4181
Viewpoint

The Future of Stroke Treatment: Bringing Evaluation of Behavior Back to Stroke Neurology

Abstract Full Text
JAMA Neurol. 2014;71(12):1473-1474. doi:10.1001/jamaneurol.2014.2343

This Viewpoint highlights aspects of future stroke treatment aimed at updating the behavioral examination and outcome measures.

Editorial

Human Neurons Derived From Induced Pluripotent Stem Cells as a New Platform for Preclinical Drug Screening and Development

Abstract Full Text
JAMA Neurol. 2014;71(12):1475-1476. doi:10.1001/jamaneurol.2014.2802

The Role of Big Data in Understanding Late-Life Cognitive Decline: E Unum, Pluribus

Abstract Full Text
JAMA Neurol. 2014;71(12):1476-1478. doi:10.1001/jamaneurol.2014.2818

Possible Role of Orexin in the Pathogenesis of Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2014;71(12):1478-1480. doi:10.1001/jamaneurol.2014.2819
Original Investigation

Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers

Abstract Full Text
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JAMA Neurol. 2014;71(12):1481-1489. doi:10.1001/jamaneurol.2014.2482

This study using cellular models reports that human neurons derived from human induced pluripotent stem cells provide a signature that will accurately reflect drug response in humans and in cerebrospinal fluid biomarker changes during γ-secretase modulator treatment for Alzheimer disease. Liao and Holtzman provide a related Article .

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma: The Role of Age and Severity

Abstract Full Text
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JAMA Neurol. 2014;71(12):1490-1497. doi:10.1001/jamaneurol.2014.2668

This retrospective cohort study found that patients with traumatic brain injury had an increased risk of developing dementia. See also the Editorial by DeKosky.

Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

Abstract Full Text
free access
JAMA Neurol. 2014;71(12):1498-1505. doi:10.1001/jamaneurol.2014.2510

This case-control study demonstrates that, in Alzheimer disease, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with the cognitive decline.

Vaccines and the Risk of Multiple Sclerosis and Other Central Nervous System Demyelinating Diseases

Abstract Full Text
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JAMA Neurol. 2014;71(12):1506-1513. doi:10.1001/jamaneurol.2014.2633

This nested, case-control study reports no longer-term association of vaccines with multiple sclerosis or other acquired central nervous system demyelinating diseases; however, there was a short-term increase in risk.

Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly

Abstract Full Text
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JAMA Neurol. 2014;71(12):1514-1519. doi:10.1001/jamaneurol.2014.1663

This genome-wide linkage analysis provides evidence for the presence of potential candidate genes related to exceptional episodic memory in the elderly.

The Phosphodiesterase 10 Positron Emission Tomography Tracer, [18F]MNI-659, as a Novel Biomarker for Early Huntington Disease

Abstract Full Text
free access
JAMA Neurol. 2014;71(12):1520-1528. doi:10.1001/jamaneurol.2014.1954

This prospective cohort study identifies [18F]MNI-659 as a promising striatal imaging biomarker for assessment of early Huntington disease.

Amyotrophic Lateral Sclerosis Risk for Spinocerebellar Ataxia Type 2 ATXN2 CAG Repeat Alleles: A Meta-analysis

Abstract Full Text
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JAMA Neurol. 2014;71(12):1529-1534. doi:10.1001/jamaneurol.2014.2082

This meta-analysis assesses the association between the number of CAG repeat alleles in the ataxin 2 gene (ATXN2) and the risk of amyotrophic lateral sclerosis across multiple ethnic groups.

Disease Penetrance of Late-Onset Parkinsonism: A Meta-analysis

Abstract Full Text
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JAMA Neurol. 2014;71(12):1535-1539. doi:10.1001/jamaneurol.2014.1909

This quantitative meta-analysis reveals that Parkinson disease pathogenic mutations have an age-dependent penetrance that could be ameliorated or exacerbated by modifier genes or environmental factors in different populations.

Quantifying the Eating Abnormalities in Frontotemporal Dementia

Abstract Full Text
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JAMA Neurol. 2014;71(12):1540-1546. doi:10.1001/jamaneurol.2014.1931

This prospective case-controlled study shows that abnormal eating behaviors are prominent in patients with behavioral variant frontotemporal dementia and those with semantic dementia.

White Matter Integrity Determined With Diffusion Tensor Imaging in Older Adults Without Dementia: Influence of Amyloid Load and Neurodegeneration

Abstract Full Text
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JAMA Neurol. 2014;71(12):1547-1554. doi:10.1001/jamaneurol.2014.1482

This population-based, longitudinal cohort study shows that a high amyloid load does not influence diffusion tensor imaging–based measures of white matter integrity in the absence of coexistent gray matter neurodegeneration in older adults without dementia.

Case Report/Case Series

Association Between Neurologic Improvement With Decline in Blood Pressure and Recanalization in Stroke

Abstract Full Text
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JAMA Neurol. 2014;71(12):1555-1558. doi:10.1001/jamaneurol.2014.2036

This case series reports that neurologic improvement with concurrent decline in systolic blood pressure of 20 mm Hg or greater after intravenous tissue plasminogen activator may be a clinical sign of recanalization in patients with stroke.

Restless Genital Syndrome in Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2014;71(12):1559-1561. doi:10.1001/jamaneurol.2014.1326

This case report describes a 65-year-old woman with Parkinson disease who had experienced genital discomfort for 3 years.

Extensive White Matter Involvement in Patients With Frontotemporal Lobar Degeneration: Think Progranulin

Abstract Full Text
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JAMA Neurol. 2014;71(12):1562-1566. doi:10.1001/jamaneurol.2014.1316

This case series shows that white matter involvement may be linked to progranulin pathological processes in a subset of GRN mutation carriers.

Review

Genetic Movement Disorders in Patients of Jewish Ancestry

Abstract Full Text
JAMA Neurol. 2014;71(12):1567-1572. doi:10.1001/jamaneurol.2014.1364

This review finds that sporadic and familial forms of Parkinson disease are more common among patients of Ashkenazi Jewish ancestry than in the non-Jewish population.

Images in Neurology

Hemidystonia With One Eye-of-the-Tiger Sign

Abstract Full Text
has multimedia
JAMA Neurol. 2014;71(12):1574-1575. doi:10.1001/jamaneurol.2014.1077
Research Letter

Association Between the Prevalence of Learning Disabilities and Primary Progressive Aphasia

Abstract Full Text
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JAMA Neurol. 2014;71(12):1576-1577. doi:10.1001/jamaneurol.2014.2805
Comment & Response

Therapeutic Hypothermia and Targeted Temperature Management After Cardiac Arrest

Abstract Full Text
JAMA Neurol. 2014;71(12):1577-1578. doi:10.1001/jamaneurol.2014.3125

Therapeutic Hypothermia and Targeted Temperature Management After Cardiac Arrest—Reply

Abstract Full Text
JAMA Neurol. 2014;71(12):1578. doi:10.1001/jamaneurol.2014.3128

Congenital Absence of Apolipoprotein E and Neurological Function

Abstract Full Text
JAMA Neurol. 2014;71(12):1578-1579. doi:10.1001/jamaneurol.2014.3342

Congenital Absence of Apolipoprotein E and Neurological Function—Reply

Abstract Full Text
JAMA Neurol. 2014;71(12):1579. doi:10.1001/jamaneurol.2014.3345

Heritability of Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. 2014;71(12):1579-1580. doi:10.1001/jamaneurol.2014.3493
Correction

Incorrect Information in Reply Letter

Abstract Full Text
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JAMA Neurol. 2014;71(12):1580. doi:10.1001/jamaneurol.2014.3796

Error in Funding/Support

Abstract Full Text
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JAMA Neurol. 2014;71(12):1580. doi:10.1001/jamaneurol.2014.3865
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(12):1468. doi:10.1001/jamaneurol.2013.4182
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