This Viewpoint highlights aspects of future stroke treatment aimed at updating the behavioral examination and outcome measures.
This study using cellular models reports that human neurons derived from human induced pluripotent stem cells provide a signature that will accurately reflect drug response in humans and in cerebrospinal fluid biomarker changes during γ-secretase modulator treatment for Alzheimer disease. Liao and Holtzman provide a related Article .
This retrospective cohort study found that patients with traumatic brain injury had an increased risk of developing dementia. See also the Editorial by DeKosky.
This case-control study demonstrates that, in Alzheimer disease, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with the cognitive decline.
This nested, case-control study reports no longer-term association of vaccines with multiple sclerosis or other acquired central nervous system demyelinating diseases; however, there was a short-term increase in risk.
This genome-wide linkage analysis provides evidence for the presence of potential candidate genes related to exceptional episodic memory in the elderly.
This prospective cohort study identifies [18F]MNI-659 as a promising striatal imaging biomarker for assessment of early Huntington disease.
This meta-analysis assesses the association between the number of CAG repeat alleles in the ataxin 2 gene (ATXN2) and the risk of amyotrophic lateral sclerosis across multiple ethnic groups.
This quantitative meta-analysis reveals that Parkinson disease pathogenic mutations have an age-dependent penetrance that could be ameliorated or exacerbated by modifier genes or environmental factors in different populations.
This prospective case-controlled study shows that abnormal eating behaviors are prominent in patients with behavioral variant frontotemporal dementia and those with semantic dementia.
This population-based, longitudinal cohort study shows that a high amyloid load does not influence diffusion tensor imaging–based measures of white matter integrity in the absence of coexistent gray matter neurodegeneration in older adults without dementia.
This case series reports that neurologic improvement with concurrent decline in systolic blood pressure of 20 mm Hg or greater after intravenous tissue plasminogen activator may be a clinical sign of recanalization in patients with stroke.
This case report describes a 65-year-old woman with Parkinson disease who had experienced genital discomfort for 3 years.
This case series shows that white matter involvement may be linked to progranulin pathological processes in a subset of GRN mutation carriers.
This review finds that sporadic and familial forms of Parkinson disease are more common among patients of Ashkenazi Jewish ancestry than in the non-Jewish population.
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