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February 2014, Vol 71, No. 2, Pages 131-244

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2014;71(2):131-133. doi:10.1001/jamaneurol.2013.4131
Viewpoint

Evidence Needs to Be Translated, Whether or Not It Is Complete

Abstract Full Text
JAMA Neurol. 2014;71(2):137-138. doi:10.1001/jamaneurol.2013.5376
Editorial

Proximal Intracranial Arterial Occlusions: Does the Natural History Justify Further Interventional Trials?

Abstract Full Text
JAMA Neurol. 2014;71(2):139-140. doi:10.1001/jamaneurol.2013.5370
Original Investigation

Clinical Trial

Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson Disease: A Randomized Clinical Trial

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JAMA Neurol. 2014;71(2):141-150. doi:10.1001/jamaneurol.2013.5528

The Parkinson Study Group SURE-PD Investigators determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early Parkinson disease and assess its suitability and potential design features for a disease-modification trial.

Prognosis of Untreated Strokes Due to Anterior Circulation Proximal Intracranial Arterial Occlusions Detected by Use of Computed Tomography Angiography

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JAMA Neurol. 2014;71(2):151-157. doi:10.1001/jamaneurol.2013.5007

In a prospective cohort study at 2 university-based hospitals between 2003 and 2005, Lima and coauthors investigate the outcomes of patients who had an acute ischemic stroke attributable to an anterior circulation proximal intracranial arterial occlusion. See the editorial by Yahgi and Marshall.

Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage

Abstract Full Text
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JAMA Neurol. 2014;71(2):158-164. doi:10.1001/jamaneurol.2013.5433

Frequency of Hematoma Expansion After Spontaneous Intracerebral Hemorrhage in Children

Abstract Full Text
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JAMA Neurol. 2014;71(2):165-171. doi:10.1001/jamaneurol.2013.4672

Beslow et al assess the frequency and extent of hematoma expansion in children with nontraumatic intracerebral hemorrhage.

Lower Motor Neuron Involvement in TAR DNA-Binding Protein of 43 kDa–Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Abstract Full Text
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JAMA Neurol. 2014;71(2):172-179. doi:10.1001/jamaneurol.2013.5489

Riku et al investigated a pathological continuity between FTLD-TDP and ALS by comparing their respective neuropathological changes in the motor neuron system.

The Role of Clusterin in Amyloid-β–Associated Neurodegeneration

Abstract Full Text
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JAMA Neurol. 2014;71(2):180-187. doi:10.1001/jamaneurol.2013.4560

Desikan and colleagues aimed to elucidate the relationship between clusterin, amyloid-β, phosphorylated tau, and rate of brain atrophy over time among nondemented older individuals.

Survival and Psychomotor Development With Early Betaine Treatment in Patients With Severe Methylenetetrahydrofolate Reductase Deficiency

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JAMA Neurol. 2014;71(2):188-194. doi:10.1001/jamaneurol.2013.4915

Diekman et al investigate the effect of betaine treatment on development and survival in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency.

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

Abstract Full Text
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JAMA Neurol. 2014;71(2):195-200. doi:10.1001/jamaneurol.2013.5390

Reed and coauthors investigate the association between serum cholesterol levels and cerebral β-amyloid early in the Alzheimer disease process.

Hypothyroidism and Risk of Mild Cognitive Impairment in Elderly Persons: A Population-Based Study

Abstract Full Text
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JAMA Neurol. 2014;71(2):201-207. doi:10.1001/jamaneurol.2013.5402

Parsaik et al evaluate the association of clinical and subclinical hypothyroidism with mild cognitive impairment in a large population-based cohort.

DCTN1 Mutation Analysis in Families With Progressive Supranuclear Palsy–Like Phenotypes

Abstract Full Text
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JAMA Neurol. 2014;71(2):208-215. doi:10.1001/jamaneurol.2013.5100

Caroppo et al analyzed the DCTN1 gene in families with a progressive supranuclear palsy–like phenotype at a referral center among 21 patients. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated. Outcome measures were identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.

Effect of TMEM106B Polymorphism on Functional Network Connectivity in Asymptomatic GRN Mutation Carriers

Abstract Full Text
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JAMA Neurol. 2014;71(2):216-221. doi:10.1001/jamaneurol.2013.4835

Premi et al ascertain whether TMEM106B genetic status modulates GRN disease by evaluating resting-state functional connectivity in aGRN+ according to TMEM106 genetic variation.

Case Report/Case Series

Steroid-Resistant Relapsing IgG4-Related Pachymeningitis Treated With Methotrexate

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JAMA Neurol. 2014;71(2):222-225. doi:10.1001/jamaneurol.2013.3950

Hyun et al describe long-term favorable response of oral methotrexate in a patient with IgG4-related pachymeningitis who was resistant to steroid therapy.

Unusual Case of Bilateral Caudate Infarcts Following Pituitary Apoplexy

Abstract Full Text
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JAMA Neurol. 2014;71(2):226-227. doi:10.1001/jamaneurol.2013.4528

Rebeiz et al describe an 81-year-old woman with a pituitary macroadenoma who presented with circulatory shock due to pituitary apoplexy. She had new asymmetric quadriparesis with chronic bilateral visual disturbance, watershed infarcts in the anterior cerebral artery–middle cerebral artery and middle cerebral artery–posterior cerebral artery watershed zones, and bilateral caudate infarcts.

Multiple Sclerosis Disease Progression and Paradichlorobenzene: A Tale of Mothballs and Toilet Cleaner

Abstract Full Text
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JAMA Neurol. 2014;71(2):228-232. doi:10.1001/jamaneurol.2013.4395

Hession et al describe the case of a woman with a diagnosis of relapsing-remitting multiple sclerosis, who continued to accumulate neurological disability despite long-term natalizumab treatment.

Clinical Implications of Basic Neuroscience Research

The Innate Immune System After Ischemic Injury: Lessons to Be Learned From the Heart and Brain

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JAMA Neurol. 2014;71(2):233-236. doi:10.1001/jamaneurol.2013.5026

Innate immune cells are critically involved in ischemic complications of atherosclerosis. Courties et al describe the immune response after stroke and myocardial infarction.

Images in Neurology

Weil Syndrome: A Rare Cause of Cerebral Venous Thrombosis

Abstract Full Text
JAMA Neurol. 2014;71(2):238-239. doi:10.1001/jamaneurol.2013.2175

A Painless Burn Due to Lack of Painkillers

Abstract Full Text
JAMA Neurol. 2014;71(2):240-241. doi:10.1001/jamaneurol.2013.2192

Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis Type 1

Abstract Full Text
JAMA Neurol. 2014;71(2):242. doi:10.1001/jamaneurol.2013.2048
Comment & Response

Cerebral Venous Air Embolism: What Is It and Do We Know How to Deal With It Properly?

Abstract Full Text
JAMA Neurol. 2014;71(2):243. doi:10.1001/jamaneurol.2013.5414

Cerebral Venous Air Embolism—Reply

Abstract Full Text
JAMA Neurol. 2014;71(2):243-244. doi:10.1001/jamaneurol.2013.5556
Correction

Incorrect Author Name

Abstract Full Text
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JAMA Neurol. 2014;71(2):244. doi:10.1001/jamaneurol.2013.6320
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(2):135. doi:10.1001/jamaneurol.2013.4132
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