The Parkinson Study Group SURE-PD Investigators determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early Parkinson disease and assess its suitability and potential design features for a disease-modification trial.
In a prospective cohort study at 2 university-based hospitals between 2003 and 2005, Lima and coauthors investigate the outcomes of patients who had an acute ischemic stroke attributable to an anterior circulation proximal intracranial arterial occlusion. See the editorial by Yahgi and Marshall.
Beslow et al assess the frequency and extent of hematoma expansion in children with nontraumatic intracerebral hemorrhage.
Riku et al investigated a pathological continuity between FTLD-TDP and ALS by comparing their respective neuropathological changes in the motor neuron system.
Desikan and colleagues aimed to elucidate the relationship between clusterin, amyloid-β, phosphorylated tau, and rate of brain atrophy over time among nondemented older individuals.
Diekman et al investigate the effect of betaine treatment on development and survival in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency.
Reed and coauthors investigate the association between serum cholesterol levels and cerebral β-amyloid early in the Alzheimer disease process.
Parsaik et al evaluate the association of clinical and subclinical hypothyroidism with mild cognitive impairment in a large population-based cohort.
Caroppo et al analyzed the DCTN1 gene in families with a progressive supranuclear palsy–like phenotype at a referral center among 21 patients. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated. Outcome measures were identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.
Premi et al ascertain whether TMEM106B genetic status modulates GRN disease by evaluating resting-state functional connectivity in aGRN+ according to TMEM106 genetic variation.
Hyun et al describe long-term favorable response of oral methotrexate in a patient with IgG4-related pachymeningitis who was resistant to steroid therapy.
Rebeiz et al describe an 81-year-old woman with a pituitary macroadenoma who presented with circulatory shock due to pituitary apoplexy. She had new asymmetric quadriparesis with chronic bilateral visual disturbance, watershed infarcts in the anterior cerebral artery–middle cerebral artery and middle cerebral artery–posterior cerebral artery watershed zones, and bilateral caudate infarcts.
Hession et al describe the case of a woman with a diagnosis of relapsing-remitting multiple sclerosis, who continued to accumulate neurological disability despite long-term natalizumab treatment.
Innate immune cells are critically involved in ischemic complications of atherosclerosis. Courties et al describe the immune response after stroke and myocardial infarction.
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