In a phase III randomized, placebo-controlled, double-blind clinical trial, Beal and coauthors examine whether coenzyme Q10 could slow disease progression in early Parkinson disease. See also the editorial by Schapira and Patel.
Van Laere and colleagues evaluated the use of 18fluorodeoxyglucose (FDG)–positron-emission tomography (PET) as a marker of amyotrophic lateral sclerosis (ALS) pathology and investigated whether a specific metabolic signature is present in patients with C9orf72 mutations. Foerster and Feldman provided a related Article .
Hughes et al examine the association between measures of arterial stiffness and change in β-amyloid deposition over time. See also the editorial by King.
Ong et al conduct a population-level study investigating the relationship between epilepsy and several common autoimmune diseases.
Liew and colleagues aimed to determine whether plasmapheresis or intravenous immunoglobulin (IVIG) therapy is more effective as maintenance therapy in juvenile myasthenia gravis.
Singh et al investigate whether a diagnosis of chronic obstructive pulmonary disease (COPD) and duration of COPD are associated with an increased risk for incident mild cognitive impairment and its subtypes.
Breen and colleagues define the sleep and circadian phenotype of patients with early-stage Parkinson disease.
Monaco et al determine whether mononuclear cells in circulation from patients with multiple sclerosis (MS) treated with natalizumab harbor DNA of the JC virus.
Serra et al use functional magnetic resonance imaging to assess the potential relationship between personality traits/disorders and changes to functional connectivity within the default mode network in patients with myotonic dystrophy type 1 (DM1).
Popa et al clarify the neurophysiological features of myoclonus-dystonia and discuss whether myoclonus-dystonia due to ε-sarcoglycan deficiency differs from other primary dystonias.
Kruer et al describe a 3-year-old boy who presented with a mixed movement disorder (opsoclonus, ataxia, and chorea) as well as seizures refractory to treatment. His seizures required continuous pentobarbital sodium infusion to be controlled. Despite treatment with intravenous corticosteroids and immunoglobulins, the patient ultimately died of overwhelming sepsis.
DeSena and colleagues reported 5 pediatric cases of transverse myelitis/acute disseminated encephalomyelitis observed from 2009-2012 at the Children’s Medical Center Dallas.
Iyer and colleagues described a 53-year-old woman presented with nausea and vomiting and was later diagnosed as having neuromyelitis optica spectrum disorder.
In a perspective review, Neuhaus and coauthors aim to provide a brief overview of the commonly used stroke models, their merits and shortcomings, and how these have contributed to translational failures. They review some recent developments in preclinical stroke, providing examples of how improved study quality and the use of novel methods can facilitate translation into the clinical setting.
A novel analgesic strategy for neuropathic pain is to restore spinal ionotropic inhibition by enhancing KCC2-mediated chloride extrusion. Kahle et al review the data on which this theory is based, discuss high-throughput screens that have searched for small-molecule activators of KCC2, and propose other strategies of KCC2 activation.
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