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September 2021 - July 1959

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May 2014, Vol 71, No. 5, Pages 525-656

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2014;71(5):525. doi:10.1001/jamaneurol.2013.4146
Viewpoint

Medicare Coverage of Investigational Devices: The Troubled Path Forward for Deep Brain Stimulation

Abstract Full Text
JAMA Neurol. 2014;71(5):535-536. doi:10.1001/jamaneurol.2013.6042
Editorial

Targeting Mitochondria for Neuroprotection in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2014;71(5):537-538. doi:10.1001/jamaneurol.2014.64

A Brighter Future for Patients With Amyotrophic Lateral Sclerosis Through Imaging?

Abstract Full Text
JAMA Neurol. 2014;71(5):539-540. doi:10.1001/jamaneurol.2014.66

Arterial Stiffness as a Potential Determinant of β-Amyloid Deposition

Abstract Full Text
JAMA Neurol. 2014;71(5):541-542. doi:10.1001/jamaneurol.2014.187
Original Investigation

Clinical Trial

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit

Abstract Full Text
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JAMA Neurol. 2014;71(5):543-552. doi:10.1001/jamaneurol.2014.131

In a phase III randomized, placebo-controlled, double-blind clinical trial, Beal and coauthors examine whether coenzyme Q10 could slow disease progression in early Parkinson disease. See also the editorial by Schapira and Patel.

Value of 18Fluorodeoxyglucose–Positron-Emission Tomography in Amyotrophic Lateral Sclerosis: A Prospective Study

Abstract Full Text
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JAMA Neurol. 2014;71(5):553-561. doi:10.1001/jamaneurol.2014.62

Van Laere and colleagues evaluated the use of 18fluorodeoxyglucose (FDG)–positron-emission tomography (PET) as a marker of amyotrophic lateral sclerosis (ALS) pathology and investigated whether a specific metabolic signature is present in patients with C9orf72 mutations. Foerster and Feldman provided a related Article .

Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults

Abstract Full Text
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JAMA Neurol. 2014;71(5):562-568. doi:10.1001/jamaneurol.2014.186

Hughes et al examine the association between measures of arterial stiffness and change in β-amyloid deposition over time. See also the editorial by King.

Population-Level Evidence for an Autoimmune Etiology of Epilepsy

Abstract Full Text
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JAMA Neurol. 2014;71(5):569-574. doi:10.1001/jamaneurol.2014.188

Ong et al conduct a population-level study investigating the relationship between epilepsy and several common autoimmune diseases.

Comparison of Plasmapheresis and Intravenous Immunoglobulin as Maintenance Therapies for Juvenile Myasthenia Gravis

Abstract Full Text
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JAMA Neurol. 2014;71(5):575-580. doi:10.1001/jamaneurol.2014.17

Liew and colleagues aimed to determine whether plasmapheresis or intravenous immunoglobulin (IVIG) therapy is more effective as maintenance therapy in juvenile myasthenia gravis.

A Prospective Study of Chronic Obstructive Pulmonary Disease and the Risk for Mild Cognitive Impairment

Abstract Full Text
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JAMA Neurol. 2014;71(5):581-588. doi:10.1001/jamaneurol.2014.94

Singh et al investigate whether a diagnosis of chronic obstructive pulmonary disease (COPD) and duration of COPD are associated with an increased risk for incident mild cognitive impairment and its subtypes.

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2014;71(5):589-595. doi:10.1001/jamaneurol.2014.65

Breen and colleagues define the sleep and circadian phenotype of patients with early-stage Parkinson disease.

JC Virus in CD34+ and CD19+ Cells in Patients With Multiple Sclerosis Treated With Natalizumab

Abstract Full Text
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JAMA Neurol. 2014;71(5):596-602. doi:10.1001/jamaneurol.2014.63

Monaco et al determine whether mononuclear cells in circulation from patients with multiple sclerosis (MS) treated with natalizumab harbor DNA of the JC virus.

Abnormal Functional Brain Connectivity and Personality Traits in Myotonic Dystrophy Type 1

Abstract Full Text
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JAMA Neurol. 2014;71(5):603-611. doi:10.1001/jamaneurol.2014.130

Serra et al use functional magnetic resonance imaging to assess the potential relationship between personality traits/disorders and changes to functional connectivity within the default mode network in patients with myotonic dystrophy type 1 (DM1).

The Neurophysiological Features of Myoclonus-Dystonia and Differentiation From Other Dystonias

Abstract Full Text
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JAMA Neurol. 2014;71(5):612-619. doi:10.1001/jamaneurol.2014.99

Popa et al clarify the neurophysiological features of myoclonus-dystonia and discuss whether myoclonus-dystonia due to ε-sarcoglycan deficiency differs from other primary dystonias.

Case Report/Case Series

Aggressive Course in Encephalitis With Opsoclonus, Ataxia, Chorea, and Seizures: The First Pediatric Case of γ-Aminobutyric Acid Type B Receptor Autoimmunity

Abstract Full Text
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JAMA Neurol. 2014;71(5):620-623. doi:10.1001/jamaneurol.2013.4786

Kruer et al describe a 3-year-old boy who presented with a mixed movement disorder (opsoclonus, ataxia, and chorea) as well as seizures refractory to treatment. His seizures required continuous pentobarbital sodium infusion to be controlled. Despite treatment with intravenous corticosteroids and immunoglobulins, the patient ultimately died of overwhelming sepsis.

Transverse Myelitis Plus Syndrome and Acute Disseminated Encephalomyelitis Plus Syndrome: A Case Series of 5 Children

Abstract Full Text
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JAMA Neurol. 2014;71(5):624-629. doi:10.1001/jamaneurol.2013.5323

DeSena and colleagues reported 5 pediatric cases of transverse myelitis/acute disseminated encephalomyelitis observed from 2009-2012 at the Children’s Medical Center Dallas.

Transverse Myelitis Associated With an Itchy Rash and HyperCKemia: Neuromyelitis Optica Associated With Dermatitis Herpetiformis

Abstract Full Text
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JAMA Neurol. 2014;71(5):630-633. doi:10.1001/jamaneurol.2013.6277

Iyer and colleagues described a 53-year-old woman presented with nausea and vomiting and was later diagnosed as having neuromyelitis optica spectrum disorder.

Review

Importance of Preclinical Research in the Development of Neuroprotective Strategies for Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2014;71(5):634-639. doi:10.1001/jamaneurol.2013.6299

In a perspective review, Neuhaus and coauthors aim to provide a brief overview of the commonly used stroke models, their merits and shortcomings, and how these have contributed to translational failures. They review some recent developments in preclinical stroke, providing examples of how improved study quality and the use of novel methods can facilitate translation into the clinical setting.

Clinical Implications of Basic Neuroscience Research

Therapeutic Restoration of Spinal Inhibition via Druggable Enhancement of Potassium-Chloride Cotransporter KCC2–Mediated Chloride Extrusion in Peripheral Neuropathic Pain

Abstract Full Text
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JAMA Neurol. 2014;71(5):640-645. doi:10.1001/jamaneurol.2014.21

A novel analgesic strategy for neuropathic pain is to restore spinal ionotropic inhibition by enhancing KCC2-mediated chloride extrusion. Kahle et al review the data on which this theory is based, discuss high-throughput screens that have searched for small-molecule activators of KCC2, and propose other strategies of KCC2 activation.

Images in Neurology

Reversibility of Brainstem Damage After a Mechanical Thrombectomy

Abstract Full Text
JAMA Neurol. 2014;71(5):646-647. doi:10.1001/jamaneurol.2013.5574

Fulminant Acute Disseminated Encephalomyelitis Presenting in an Adult

Abstract Full Text
JAMA Neurol. 2014;71(5):648-649. doi:10.1001/jamaneurol.2014.34
Research Letter

Diagnostic Yield of Clinical Next-Generation Sequencing Panels for Epilepsy

Abstract Full Text
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JAMA Neurol. 2014;71(5):650-651. doi:10.1001/jamaneurol.2014.405
Comment & Response

Self-Reported Sleep and β-Amyloid Deposition in Older Adults

Abstract Full Text
JAMA Neurol. 2014;71(5):651. doi:10.1001/jamaneurol.2013.6417

Self-Reported Sleep and β-Amyloid Deposition in Older Adults—Reply

Abstract Full Text
JAMA Neurol. 2014;71(5):651-652. doi:10.1001/jamaneurol.2014.167

The Future of Neuroscience Clinical Trials

Abstract Full Text
JAMA Neurol. 2014;71(5):652. doi:10.1001/jamaneurol.2014.165

The Future of Neuroscience Clinical Trials—Reply

Abstract Full Text
JAMA Neurol. 2014;71(5):652-653. doi:10.1001/jamaneurol.2014.170

Serum Brain-Derived Neurotrophic Factor as a Predictor of Incident Dementia

Abstract Full Text
JAMA Neurol. 2014;71(5):653. doi:10.1001/jamaneurol.2013.6414

Serum Brain-Derived Neurotrophic Factor as a Predictor of Incident Dementia—Reply

Abstract Full Text
JAMA Neurol. 2014;71(5):653-654. doi:10.1001/jamaneurol.2014.215

Creating a Concussion Crisis and Chronic Traumatic Encephalopathy

Abstract Full Text
JAMA Neurol. 2014;71(5):654. doi:10.1001/jamaneurol.2013.6408

When to Tell an Athlete to Stop Playing

Abstract Full Text
JAMA Neurol. 2014;71(5):654-655. doi:10.1001/jamaneurol.2013.6411

DCTN1 Mutations and Progressive Supranuclear Palsy–Like Phenotype

Abstract Full Text
JAMA Neurol. 2014;71(5):655. doi:10.1001/jamaneurol.2014.227
Book and Media Review

Review of Neuroinfections

Abstract Full Text
JAMA Neurol. 2014;71(5):656. doi:10.1001/jamaneurol.2014.166
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(5):531. doi:10.1001/jamaneurol.2013.4147
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