Shahim et al determine whether sports-related concussion is associated with elevated levels of blood biochemical markers of injury to the central nervous system and assess whether plasma levels of these biomarkers predict return to play in professional ice hockey players with sports-related concussion. Gatson and Diaz-Arrastia provide commentary in a related editorial.
Wall and colleagues reported the baseline clinical and laboratory features of patients enrolled in the Idiopathic Intracranial Hypertension Treatment Trial. Volpe provided a related Article .
Burkholder and colleagues determine whether the following are associated with surgical outcomes in patients with magnetic resonance imaging-negative temporal lobe epilepsy who underwent standard anterior temporal lobectomy: (1) unilateral-only interictal epileptiform discharges on preoperative scalp electroencephalogram; (2) complete resection of tissue generating interictal epileptiform discharges on electrocorticography; (3) complete resection of opioid-induced interictal epileptiform discharges recorded on electrocorticography; and (4) location of interictal epileptiform discharges recorded on electrocorticography.
In an inception cohort analysis of data from 413 patients with early, untreated Parkinson disease who were enrolled in 2 multicenter, randomized, double-blind clinical trials, Parashos and coauthors examine the value of measures of impairment, disability, and quality of life in assessing progression in early Parkinson disease.
To characterize the organization of neuroglial elements within ovarian teratomas resected from patients with NMDAR encephalitis, Day et al performed a case-control study. Outcome measures were atypical CNS neuronal elements in ovarian teratomas resected from cases vs controls and the relationship between atypical neurons and immune infiltrates.
Mattsson et al test the hypothesis that the development of Aβ pathology is related to increased regional atrophy in the brains of cognitively normal (CN) persons. They studied 47 CN control subjects and 15 patients with AD dementia. The main outcome measures were group effects on regional gray matter volumes at baseline and over time.
In a blinded, retrospective case-control study using medical records from 2000 to 2007 obtained from an magnetic resonance imaging (MRI) database at the Mayo Clinic in Rochester, Minnesota, Burnett and coauthors determine the clinical features associated with Swiss cheese striatum detected on MRI scans.
Li et al examine biomarkers indicative of age-related cognitive decline among older individuals with normal cognition in a cross-sectional and longitudinal study.
Alcalay and colleagues estimate the age-specific risk of PD in Ashkenazi Jewish patients with type 1 GD and in GBA heterozygotes.
Hsiao and colleagues used [18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-DTBZ) positron emission tomography to explore the characteristics of vesicular monoamine transporter type 2 imaging in patients with Parkinson disease (PD) with different severity levels as well as to investigate its capability in monitoring clinical severity.
Regev and coauthors described a patient with multiorgan IgG4-related disease who developed progressive spastic hemiparesis and dementia.
Goldman and colleagues described a 65-year-old woman had a 2-year history of ataxia with autonomic dysfunction, but without motor neuron signs, who was diagnosed as having multiple system atrophy (MSA) based on her clinical history and the hot cross bun sign on brain magnetic resonance imaging.
Bieniek and coauthors assess the incidence of the expanded C9ORF72 repeat in cases of depressive Pseudodementia.
Holder et al describe an infant who had the characteristic presentation of isolated sulfite oxidase deficiency but, in addition to seizures, developed infantile spasms and hyperekplexia.
Lu and colleagues summarize the current knowledge on IgG4-RHP including its pathological, clinical, and radiological presentations. Particular emphasis is placed on diagnostic and therapeutic implications.
Ghadiri and coauthors report of a case in which a 42-year-old white man presented with cognitive impairment and behavioral changes followed by rapidly progressive motor and gait impairment. Magnetic resonance imaging revealed striking multifocal white matter signal change, areas of restricted diffusion, diffuse callosal signal change, and atrophy and hyperintensity of the corticospinal tracts.