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July 2014, Vol 71, No. 7, Pages 815-928

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2014;71(7):815. doi:10.1001/jamaneurol.2013.4156
Viewpoint

Therapeutic Hypothermia After Cardiac Arrest Without Return of Consciousness: Skating on Thin Ice

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JAMA Neurol. 2014;71(7):823-824. doi:10.1001/jamaneurol.2014.298
Editorial

Coexpression Networks Predict Ataxia Genes

Abstract Full Text
JAMA Neurol. 2014;71(7):825-828. doi:10.1001/jamaneurol.2014.757

Magnetic Resonance Spectroscopy: A Possible In Vivo Marker of Disease Progression for Multiple Sclerosis?

Abstract Full Text
JAMA Neurol. 2014;71(7):828-830. doi:10.1001/jamaneurol.2014.896
Original Investigation

Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia

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JAMA Neurol. 2014;71(7):831-839. doi:10.1001/jamaneurol.2014.756

Bettencourt et al address the possible relationships among known spinocerebellar ataxia genes, predict their functions, identify overlapping pathways, and provide a framework for candidate gene discovery using whole-transcriptome expression data. They analyzed 788 brain samples obtained from 101 healthy individuals. See the editorial by Pulst and Pflieger.

Magnetic Resonance Spectroscopy Markers of Disease Progression in Multiple Sclerosis

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JAMA Neurol. 2014;71(7):840-847. doi:10.1001/jamaneurol.2014.895

Llufriu and colleagues evaluated the potential of magnetic resonance spectroscopy (MRS) markers of central nervous system injury to predict brain-volume loss and clinical disability in multiple sclerosis. Miller provided a related Article .

A Simple Risk Index and Thrombolytic Treatment Response in Acute Ischemic Stroke

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JAMA Neurol. 2014;71(7):848-854. doi:10.1001/jamaneurol.2014.689

Using an international repository of clinical trials data, Ovbiagele and coauthors assess the relationship between SPAN-100 index (Stroke Prognostication using Age and the NIH Stroke Scale index, created by combining age in years plus National Institutes of Health Stroke Scale score of 100 or higher) status and outcome following treatment with intravenous thrombolysis for acute ischemic stroke.

Associations Between Cerebral Small-Vessel Disease and Alzheimer Disease Pathology as Measured by Cerebrospinal Fluid Biomarkers

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JAMA Neurol. 2014;71(7):855-862. doi:10.1001/jamaneurol.2014.754

Kester and colleagues determine associations between small-vessel disease and Alzheimer disease pathology.

Vitamin D and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study

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JAMA Neurol. 2014;71(7):863-871. doi:10.1001/jamaneurol.2014.755

Michos et al examine the relationship of 25-hydroxyvitamin D levels with cerebrovascular abnormalities as assessed on brain magnetic resonance imaging (MRI) among participants of the Atherosclerosis Risk in Communities Brain MRI study.

Predicting Aggressive Decline in Mild Cognitive Impairment: The Importance of White Matter Hyperintensities

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JAMA Neurol. 2014;71(7):872-877. doi:10.1001/jamaneurol.2014.667

Tosto and colleagues examined the degree to which white matter hyperintensities (WMHs) predict aggressive cognitive decline among individuals with mild cognitive impairment (MCI), either independently or by modifying the effects of entorhinal cortex volume, a marker of Alzheimer disease–related neurodegeneration.

Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence of APOE Genotype in Persons With Pathologically Verified Alzheimer Disease

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JAMA Neurol. 2014;71(7):878-883. doi:10.1001/jamaneurol.2014.681

Ringman et al determine pathological correlates and clinical factors identifiable during life that predict the presence of severe cerebral amyloid angiopathy (CAA) in persons with pathologically confirmed Alzheimer disease.

Prevalence, Determinants, and Effect on Quality of Life of Freezing of Gait in Parkinson Disease

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JAMA Neurol. 2014;71(7):884-890. doi:10.1001/jamaneurol.2014.753

Perez-Lloret et al determine the prevalence of freezing of gait in patients with Parkinson disease (PD). They assess its relationship with quality of life and explore factors between the off and on states in patients with motor fluctuations.

Case Report/Case Series

Natalizumab Use During the Third Trimester of Pregnancy

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JAMA Neurol. 2014;71(7):891-895. doi:10.1001/jamaneurol.2014.209

Haghikia and colleagues provided a case series of 12 women with 13 pregnancies and highly active multiple sclerosis who were treated with natalizumab during their third trimester of pregnancy and they assessed the clinical and laboratory effects on the newborns.

Effect of Rituximab in Patients With Leucine-Rich, Glioma-Inactivated 1 Antibody–Associated Encephalopathy

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JAMA Neurol. 2014;71(7):896-900. doi:10.1001/jamaneurol.2014.463

Irani and colleagues report on the effects of rituximab therapy in 5 patients with leucine-rich, glioma-inactivated 1 (LGI1) antibody–associated encephalopathy.

Severe Methylenetetrahydrofolate Reductase Deficiency: Clinical Clues to a Potentially Treatable Cause of Adult-Onset Hereditary Spastic Paraplegia

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JAMA Neurol. 2014;71(7):901-904. doi:10.1001/jamaneurol.2014.116

Lossos and colleagues explore the potential therapeutic benefit of betaine supplementation in siblings with severe methylenetetrahydrofolate reductase deficiency manifesting a complicated form of adult-onset hereditary spastic paraparesis.

Review

Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis: In Search of Biomarkers

Abstract Full Text
JAMA Neurol. 2014;71(7):905-912. doi:10.1001/jamaneurol.2014.395

Alvermann et al present a comprehensive review of cellular alterations in cerebrospinal fluid (CSF) that distinguish multiple sclerosis (MS) from physiological conditions and other central nervous system (CNS) disorders; integrate relevant findings into a model of leukocyte trafficking in the CNS; and evaluate the potential of CSF immunophenotyping in search of novel biomarkers in MS.

Images in Neurology

The Saddle and the Horse’s Tail: Cauda Equina Syndrome

Abstract Full Text
JAMA Neurol. 2014;71(7):914-915. doi:10.1001/jamaneurol.2013.6008

Suspected Subdural Hematoma

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JAMA Neurol. 2014;71(7):916-917. doi:10.1001/jamaneurol.2013.6013

Magnetic Resonance Imaging Observations in Primary Central Nervous System Lymphoma

Abstract Full Text
JAMA Neurol. 2014;71(7):918-919. doi:10.1001/jamaneurol.2014.70
Research Letter

Relationship Between Leukocyte Telomere Length, Telomerase Activity, and Hippocampal Volume in Early Aging

Abstract Full Text
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JAMA Neurol. 2014;71(7):921-923. doi:10.1001/jamaneurol.2014.870
Comment & Response

Features of Neuromyelitis Optica Spectrum Disorders With Aquaporin-4 and Myelin-Oligodendrocyte Glycoprotein Antibodies

Abstract Full Text
JAMA Neurol. 2014;71(7):923-924. doi:10.1001/jamaneurol.2014.764

Moving to Fingolimod From Natalizumab in Multiple Sclerosis: The ENIGM Is Not Solved

Abstract Full Text
JAMA Neurol. 2014;71(7):924-925. doi:10.1001/jamaneurol.2014.1135

Features of Neuromyelitis Optica Spectrum Disorders and Aquaporin-4 With Myelin-Oligodendrocyte Glycoprotein Antibodies—Reply

Abstract Full Text
JAMA Neurol. 2014;71(7):924. doi:10.1001/jamaneurol.2014.940

Tau, S-100 Calcium-Binding Protein B, and Neuron-Specific Enolase as Biomarkers of Concussion

Abstract Full Text
JAMA Neurol. 2014;71(7):925-926. doi:10.1001/jamaneurol.2014.1082

Moving to Fingolimod From Natalizumab in Multiple Sclerosis—Reply

Abstract Full Text
JAMA Neurol. 2014;71(7):925. doi:10.1001/jamaneurol.2014.1138

Tau, S-100 Calcium-Binding Protein B, and Neuron-Specific Enolase as Biomarkers of Concussion—Reply

Abstract Full Text
JAMA Neurol. 2014;71(7):926-927. doi:10.1001/jamaneurol.2014.1160
Book and Media Review

Review of Practical Neurology Visual

Abstract Full Text
JAMA Neurol. 2014;71(7):928. doi:10.1001/jamaneurol.2014.973
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2014;71(7):818. doi:10.1001/jamaneurol.2013.4157
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