[Skip to Navigation]

September 2021 - July 1959

Decade

Year

Issue

August 2014, Vol 71, No. 8, Pages 935-1060

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):935. doi:10.1001/jamaneurol.2013.4161
Editorial

Does Natalizumab Therapy Benefit Patients With Multiple Sclerosis?

Abstract Full Text
JAMA Neurol. 2014;71(8):945-946. doi:10.1001/jamaneurol.2014.1201

Secondary Prevention Trials in Alzheimer Disease: The Challenge of Identifying a Meaningful End Point

Abstract Full Text
JAMA Neurol. 2014;71(8):947-949. doi:10.1001/jamaneurol.2014.1120
Original Investigation

Treatment of Relapsing-Remitting Multiple Sclerosis After 24 Doses of Natalizumab: Evidence From an Italian Spontaneous, Prospective, and Observational Study (the TY-STOP Study)

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):954-960. doi:10.1001/jamaneurol.2014.1200

Clerico et al evaluate the effect of therapeutic choices on the mean annualized relapse rate and on magnetic resonance imaging multiple sclerosis activity after 24 doses of natalizumab in 124 patients with relapsing-remitting disease. Patients were recruited and stratified into an intent-to-treat group and an as-treated group. See the Editorial by Stüve and Cutter.

The Preclinical Alzheimer Cognitive Composite: Measuring Amyloid-Related Decline

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):961-970. doi:10.1001/jamaneurol.2014.803

Donohue and coauthors demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of Alzheimer disease pathology using the Alzheimer’s Disease Cooperative Study Preclinical Alzheimer Cognitive Composite. See the editorial by Kryscio.

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):971-977. doi:10.1001/jamaneurol.2014.1173

Ooms and colleagues determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in healthy middle-aged men.

Body Mass Index and Death by Stroke: No Obesity Paradox

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):978-984. doi:10.1001/jamaneurol.2014.1017

Dehlendorff and colleagues aimed to determine whether the obesity paradox in stroke is real or an artificial finding due to selection bias.

Effectiveness of Antiepileptic Drug Combination Therapy for Partial-Onset Seizures Based on Mechanisms of Action

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):985-993. doi:10.1001/jamaneurol.2014.808

Margolis and colleagues compared treatment persistence and health care use with antiepileptic drug combinations categorized by mechanism of action in patients with partial-onset seizures.

Prospectively Assessed Clinical Outcomes in Concussive Blast vs Nonblast Traumatic Brain Injury Among Evacuated US Military Personnel

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):994-1002. doi:10.1001/jamaneurol.2014.1114

Mac Donald et al determine similarities and differences between clinical outcomes in US military personnel with blast-related vs non–blast-related concussive traumatic brain injury and identify domains of impairment that best correlate with overall disability among personnel enrolled from 2010 to 2013 and evaluated at 6 to 12 months after injury.

Antibodies to Delta/Notch-like Epidermal Growth Factor–Related Receptor in Patients With Anti-Tr, Paraneoplastic Cerebellar Degeneration, and Hodgkin Lymphoma

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1003-1008. doi:10.1001/jamaneurol.2014.999

Greene et al describe a patient with anti-Tr and confirm that Delta/notch-like epidermal growth factor–related receptor (DNER) is the autoantigen in a series of patients with anti-Tr immune response.

Cerebellar Ataxia and Glutamic Acid Decarboxylase Antibodies: Immunologic Profile and Long-term Effect of Immunotherapy

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1009-1016. doi:10.1001/jamaneurol.2014.1011

Ariño et al report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in 34 patients with cerebellar ataxia and GAD65-Abs in a retrospective cohort study with laboratory investigations at a center for autoimmune neurologic disorders. Twenty-eight patients with stiff person syndrome and GAD65-Abs served as control subjects.

Association of Lifetime Intellectual Enrichment With Cognitive Decline in the Older Population

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1017-1024. doi:10.1001/jamaneurol.2014.963

Vemuri and coauthors investigate the association of lifetime intellectual enrichment with baseline cognitive performance and rate of cognitive decline in an older population without dementia.

Case Report/Case Series

Autoimmune Aquaporin-4 Myopathy in Neuromyelitis Optica Spectrum

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1025-1029. doi:10.1001/jamaneurol.2014.775

Guo and coauthors report a case of autoimmune aquaporin-4 (AQP4) myopathy in which a 51-year-old woman had relapsing optic neuritis, transverse myelitis, AQP4-IgG seropositivity, and recurrent myalgias with hyperCKemia.

Treatment of Progressive Multifocal Leukoencephalopathy With Interleukin 7

Abstract Full Text
free access has multimedia
JAMA Neurol. 2014;71(8):1030-1035. doi:10.1001/jamaneurol.2014.825

Alstadhaug and coauthors describe use of recombinant human interleukin 7 in a patient with idiopathic CD4+ T-cell lymphocytopenia.

Review

Charcot-Marie-Tooth Disease Type 2A: From Typical to Rare Phenotypic and Genotypic Features

Abstract Full Text
JAMA Neurol. 2014;71(8):1036-1042. doi:10.1001/jamaneurol.2014.629

Bombelli et al describe the clinical and molecular features of Charcot-Marie-Tooth disease type 2A and explore connections between phenotypic features and serious clinical consequences and interactions among associated genes.

Clinical Pathologic Conference

An Independent Elderly Woman With Rapid Onset of Coma

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1043-1047. doi:10.1001/jamaneurol.2014.449

Xu et al report a case of an independent elderly woman with rapid onset of coma.

Images in Neurology

Massive Pontine Microbleeds in a Patient With CADASIL

Abstract Full Text
JAMA Neurol. 2014;71(8):1048-1049. doi:10.1001/jamaneurol.2014.45

Ipsilateral Hypoglossal and Oculosympathetic Paresis in Carotid Dissection

Abstract Full Text
JAMA Neurol. 2014;71(8):1050. doi:10.1001/jamaneurol.2013.6378
Comment & Response

Alzheimer Disease Risk Factors

Abstract Full Text
JAMA Neurol. 2014;71(8):1051. doi:10.1001/jamaneurol.2014.1525

Alzheimer Disease Risk Factors—Reply

Abstract Full Text
JAMA Neurol. 2014;71(8):1051-1052. doi:10.1001/jamaneurol.2014.636

GNAL Mutations and Dystonia

Abstract Full Text
JAMA Neurol. 2014;71(8):1052-1053. doi:10.1001/jamaneurol.2014.1506

GNAL Mutations and Dystonia—Reply

Abstract Full Text
JAMA Neurol. 2014;71(8):1053-1054. doi:10.1001/jamaneurol.2014.1509

Blood Test for Variant Creutzfeldt-Jakob Disease—Reply

Abstract Full Text
JAMA Neurol. 2014;71(8):1054-1055. doi:10.1001/jamaneurol.2014.1539

Blood Test for Variant Creutzfeldt-Jakob Disease

Abstract Full Text
JAMA Neurol. 2014;71(8):1054. doi:10.1001/jamaneurol.2014.944

Elevated Serum DDE and Risk for Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2014;71(8):1055-1056. doi:10.1001/jamaneurol.2014.432

Defining the New End Point for Multiple Sclerosis Treatment

Abstract Full Text
JAMA Neurol. 2014;71(8):1056-1057. doi:10.1001/jamaneurol.2014.1542

Elevated Serum DDE and Risk for Alzheimer Disease—Reply

Abstract Full Text
JAMA Neurol. 2014;71(8):1056. doi:10.1001/jamaneurol.2014.1548
Correction

Incorrect Information in the Abstract

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):1057. doi:10.1001/jamaneurol.2014.2274
Book and Media Review

Review of The Genetic Basis of Sleep and Sleep Disorders

Abstract Full Text
JAMA Neurol. 2014;71(8):1058-1060. doi:10.1001/jamaneurol.2014.1451
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2014;71(8):939. doi:10.1001/jamaneurol.2013.4162
×