Clerico et al evaluate the effect of therapeutic choices on the mean annualized relapse rate and on magnetic resonance imaging multiple sclerosis activity after 24 doses of natalizumab in 124 patients with relapsing-remitting disease. Patients were recruited and stratified into an intent-to-treat group and an as-treated group. See the Editorial by Stüve and Cutter.
Donohue and coauthors demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of Alzheimer disease pathology using the Alzheimer’s Disease Cooperative Study Preclinical Alzheimer Cognitive Composite. See the editorial by Kryscio.
Ooms and colleagues determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in healthy middle-aged men.
Dehlendorff and colleagues aimed to determine whether the obesity paradox in stroke is real or an artificial finding due to selection bias.
Margolis and colleagues compared treatment persistence and health care use with antiepileptic drug combinations categorized by mechanism of action in patients with partial-onset seizures.
Mac Donald et al determine similarities and differences between clinical outcomes in US military personnel with blast-related vs non–blast-related concussive traumatic brain injury and identify domains of impairment that best correlate with overall disability among personnel enrolled from 2010 to 2013 and evaluated at 6 to 12 months after injury.
Greene et al describe a patient with anti-Tr and confirm that Delta/notch-like epidermal growth factor–related receptor (DNER) is the autoantigen in a series of patients with anti-Tr immune response.
Ariño et al report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in 34 patients with cerebellar ataxia and GAD65-Abs in a retrospective cohort study with laboratory investigations at a center for autoimmune neurologic disorders. Twenty-eight patients with stiff person syndrome and GAD65-Abs served as control subjects.
Vemuri and coauthors investigate the association of lifetime intellectual enrichment with baseline cognitive performance and rate of cognitive decline in an older population without dementia.
Guo and coauthors report a case of autoimmune aquaporin-4 (AQP4) myopathy in which a 51-year-old woman had relapsing optic neuritis, transverse myelitis, AQP4-IgG seropositivity, and recurrent myalgias with hyperCKemia.
Alstadhaug and coauthors describe use of recombinant human interleukin 7 in a patient with idiopathic CD4+ T-cell lymphocytopenia.
Bombelli et al describe the clinical and molecular features of Charcot-Marie-Tooth disease type 2A and explore connections between phenotypic features and serious clinical consequences and interactions among associated genes.
Xu et al report a case of an independent elderly woman with rapid onset of coma.