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August 2019 - July 1959

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Issue

September 2014, Vol 71, No. 9, Pages 1069-1195

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2014;71(9):1069. doi:10.1001/jamaneurol.2013.4166
Viewpoint

Neurology’s Stake in Foundational Neuroscience Research

Abstract Full Text
JAMA Neurol. 2014;71(9):1081-1082. doi:10.1001/jamaneurol.2014.1496
Editorial

Targeting the Immune System in Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2014;71(9):1083-1084. doi:10.1001/jamaneurol.2014.1653

Diet and Risk of Amyotrophic Lateral Sclerosis: Is Lifestyle Important?

Abstract Full Text
JAMA Neurol. 2014;71(9):1085-1086. doi:10.1001/jamaneurol.2014.1894

The Value of Biomarker Comparisons Between Autosomal Dominant and Late-Onset Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2014;71(9):1087-1088. doi:10.1001/jamaneurol.2014.1747
Original Investigation

Fingolimod for the Treatment of Intracerebral Hemorrhage: A 2-Arm Proof-of-Concept Study

Abstract Full Text
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JAMA Neurol. 2014;71(9):1092-1101. doi:10.1001/jamaneurol.2014.1065

Fu and colleagues investigated whether oral administration of fingolimod is safe and effective in alleviating perihematomal edema and neurologic deficits in patients with intracerebral hemorrhage. Sheth and Rosand provided a related Article .

Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2014;71(9):1102-1110. doi:10.1001/jamaneurol.2014.1214

Fitzgerald and colleagues examined the association between ω-6 and ω-3 polyunsaturated fatty acid (PUFA) consumption and the risk for amyotrophic lateral sclerosis (ALS). Swash provided a related Article .

Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease

Abstract Full Text
free access has multimedia
JAMA Neurol. 2014;71(9):1111-1122. doi:10.1001/jamaneurol.2014.1654

Genome-Wide Analysis of the Heritability of Amyotrophic Lateral Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2014;71(9):1123-1134. doi:10.1001/jamaneurol.2014.1184

Keller and coauthors estimate the relative importance of genetic factors in a complex disease such as amyotrophic lateral sclerosis by accurately quantifying heritability using genome-wide data derived from genome-wide association studies.

Amyotrophic Lateral Sclerosis Outcome Measures and the Role of Albumin and Creatinine: A Population-Based Study

Abstract Full Text
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JAMA Neurol. 2014;71(9):1134-1142. doi:10.1001/jamaneurol.2014.1129

Chiò and colleagues correlate several hematological markers evaluated at diagnosis with ALS outcome in a population-based series of patients (discovery cohort) and replicate the findings in an independent validation cohort from an ALS tertiary center.

Role of Neurologists and Diagnostic Tests on the Management of Distal Symmetric Polyneuropathy

Abstract Full Text
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JAMA Neurol. 2014;71(9):1143-1149. doi:10.1001/jamaneurol.2014.1279

Callaghan and coauthors determine how often neurologists and diagnostic tests influence the diagnosis and treatment of patients with distal symmetric polyneuropathy.

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain

Abstract Full Text
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JAMA Neurol. 2014;71(9):1150-1154. doi:10.1001/jamaneurol.2014.1428

Peskind et al identify potentially modifiable risk factors associated with increased markers of brain oxidative stress.

Hospital Variation in Thrombolysis Times Among Patients With Acute Ischemic Stroke: The Contributions of Door-to-Imaging Time and Imaging-to-Needle Time

Abstract Full Text
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JAMA Neurol. 2014;71(9):1155-1161. doi:10.1001/jamaneurol.2014.1528

Sauser et al examine the contributions of door-to-imaging time and imaging-to-needle time to delays in delivery of tissue plasminogen activator to patients with acute ischemic stroke.

A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism: Phenotype-Genotype Correlations

Abstract Full Text
free access
JAMA Neurol. 2014;71(9):1162-1171. doi:10.1001/jamaneurol.2014.994

Kara and colleagues report a novel family carrying a heterozygous 6.4 Mb duplication of the alpha-synuclein locus with an atypical clinical presentation strongly reminiscent of frontotemporal dementia and late-onset pallidopyramidal syndromes and study phenotype-genotype correlations in α-synuclein locus duplications.

Case Report/Case Series

Comparing Moral Judgments of Patients With Frontotemporal Dementia and Frontal Stroke

Abstract Full Text
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JAMA Neurol. 2014;71(9):1172-1176. doi:10.1001/jamaneurol.2014.347

Woman With X-Linked Recessive Dystonia-Parkinsonism: Clue to the Epidemiology of Parkinsonism in Filipino Women?

Abstract Full Text
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JAMA Neurol. 2014;71(9):1177-1180. doi:10.1001/jamaneurol.2014.56

Domingo and colleagues provided a case report of a Filipino woman with suspected Parkinson disease in whom they confirmed the presence of all changes specific for X-linked dystonia-parkinsonism in genomic DNA.

Review

Symptomatic Intracerebral Hemorrhage in Acute Ischemic Stroke After Thrombolysis With Intravenous Recombinant Tissue Plasminogen Activator: A Review of Natural History and Treatment

Abstract Full Text
JAMA Neurol. 2014;71(9):1181-1185. doi:10.1001/jamaneurol.2014.1210

Yaghi et al provide an overview on the rationale and mechanism of action of potential treatments for symptomatic intracerebral hemorrhage that may reverse the coagulopathy before hematoma expansion occurs after intravenous recombinant tissue plasminogen activator is administered.

Images in Neurology

Serial Magnetic Resonance Imaging Changes in Sporadic Creutzfeldt-Jakob Disease With Valine Homozygosity at Codon 129 of the Prion Protein Gene

Abstract Full Text
JAMA Neurol. 2014;71(9):1186-1187. doi:10.1001/jamaneurol.2014.548
Research Letter

Alcohol Misuse Disorders and Multiple Sclerosis Risk

Abstract Full Text
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JAMA Neurol. 2014;71(9):1188-1189. doi:10.1001/jamaneurol.2014.1795

This study explores the association between alcohol misuse disorders and multiple sclerosis risk, particularly in men.

Comment & Response

Testosterone as the Missing Link Between Pesticides, Alzheimer Disease, and Parkinson Disease

Abstract Full Text
JAMA Neurol. 2014;71(9):1189-1190. doi:10.1001/jamaneurol.2014.795

Multiple System Atrophy and Repeat Expansions in C9orf72

Abstract Full Text
JAMA Neurol. 2014;71(9):1190-1191. doi:10.1001/jamaneurol.2014.1808

Testosterone as the Missing Link Between Pesticides, Alzheimer Disease, and Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2014;71(9):1190. doi:10.1001/jamaneurol.2014.1814

Multiple System Atrophy and Repeat Expansions in C9orf72—Reply

Abstract Full Text
JAMA Neurol. 2014;71(9):1191-1192. doi:10.1001/jamaneurol.2014.1811

Relevance of CD34+ Cells as a Reservoir for JC Virus in Patients With Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2014;71(9):1192. doi:10.1001/jamaneurol.2014.1855

Relevance of CD34+ Cells as a Reservoir for JC Virus in Patients With Multiple Sclerosis—Reply

Abstract Full Text
JAMA Neurol. 2014;71(9):1192-1193. doi:10.1001/jamaneurol.2014.1858

Brief Rhythmic Discharges in Electroencephalography on an Interictal to Ictal Continuum

Abstract Full Text
JAMA Neurol. 2014;71(9):1193. doi:10.1001/jamaneurol.2014.1862

Brief Rhythmic Discharges in Electroencephalography on an Interictal to Ictal Continuum—Reply

Abstract Full Text
JAMA Neurol. 2014;71(9):1193-1194. doi:10.1001/jamaneurol.2014.1865
Book and Media Review

Review of Controversies in Neuro-Oncology: Best Evidence Medicine for Brain Tumor Surgery

Abstract Full Text
JAMA Neurol. 2014;71(9):1195. doi:10.1001/jamaneurol.2014.1823
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2014;71(9):1076. doi:10.1001/jamaneurol.2013.4167
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