Fu and colleagues investigated whether oral administration of fingolimod is safe and effective in alleviating perihematomal edema and neurologic deficits in patients with intracerebral hemorrhage. Sheth and Rosand provided a related Article .
Fitzgerald and colleagues examined the association between ω-6 and ω-3 polyunsaturated fatty acid (PUFA) consumption and the risk for amyotrophic lateral sclerosis (ALS). Swash provided a related Article .
Keller and coauthors estimate the relative importance of genetic factors in a complex disease such as amyotrophic lateral sclerosis by accurately quantifying heritability using genome-wide data derived from genome-wide association studies.
Chiò and colleagues correlate several hematological markers evaluated at diagnosis with ALS outcome in a population-based series of patients (discovery cohort) and replicate the findings in an independent validation cohort from an ALS tertiary center.
Callaghan and coauthors determine how often neurologists and diagnostic tests influence the diagnosis and treatment of patients with distal symmetric polyneuropathy.
Peskind et al identify potentially modifiable risk factors associated with increased markers of brain oxidative stress.
Sauser et al examine the contributions of door-to-imaging time and imaging-to-needle time to delays in delivery of tissue plasminogen activator to patients with acute ischemic stroke.
Kara and colleagues report a novel family carrying a heterozygous 6.4 Mb duplication of the alpha-synuclein locus with an atypical clinical presentation strongly reminiscent of frontotemporal dementia and late-onset pallidopyramidal syndromes and study phenotype-genotype correlations in α-synuclein locus duplications.
Domingo and colleagues provided a case report of a Filipino woman with suspected Parkinson disease in whom they confirmed the presence of all changes specific for X-linked dystonia-parkinsonism in genomic DNA.
Yaghi et al provide an overview on the rationale and mechanism of action of potential treatments for symptomatic intracerebral hemorrhage that may reverse the coagulopathy before hematoma expansion occurs after intravenous recombinant tissue plasminogen activator is administered.
This study explores the association between alcohol misuse disorders and multiple sclerosis risk, particularly in men.