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July 2019 - July 1959

Decade

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Issue

January 2015, Vol 72, No. 1, Pages 3-131

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2015;72(1):3. doi:10.1001/jamaneurol.2014.2826
Viewpoint

The Future of Research in Neuropathy

Abstract Full Text
JAMA Neurol. 2015;72(1):5-7. doi:10.1001/jamaneurol.2014.2346

This viewpoint focuses on the technological advances in nucleotide sequencing and genetic engineering and on our deepening understanding of the molecular processes underlying Schwann cell–axon interactions and axonal degeneration.

Editorial

Exploring the Epigenetics of Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2015;72(1):8-9. doi:10.1001/jamaneurol.2014.3057

Prehospital Thrombolysis for Stroke: An Idea Whose Golden Hour Has Arrived

Abstract Full Text
JAMA Neurol. 2015;72(1):9-10. doi:10.1001/jamaneurol.2014.3389

Fingolimod and Risk of Varicella-Zoster Virus Infection: Back to the Future With an Old Infection and a New Drug

Abstract Full Text
JAMA Neurol. 2015;72(1):10-13. doi:10.1001/jamaneurol.2014.3390
Original Investigation

Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2015;72(1):15-24. doi:10.1001/jamaneurol.2014.3049

Ongoing community-based clinical pathological cohort studies of aging and dementia demonstrate that brain DNA methylation in multiple AD loci is associated with AD pathologies.

Effects of Golden Hour Thrombolysis: A Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) Substudy

Abstract Full Text
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JAMA Neurol. 2015;72(1):25-30. doi:10.1001/jamaneurol.2014.3188

A substudy of the prospective controlled Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke study indicates that golden hour thrombolysis increases with the deployment of a stroke emergency mobile unit.

Varicella-Zoster Virus Infections in Patients Treated With Fingolimod: Risk Assessment and Consensus Recommendations for Management

Abstract Full Text
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JAMA Neurol. 2015;72(1):31-39. doi:10.1001/jamaneurol.2014.3065

This analysis of pooled data from 6 completed phase 2 and 3 studies of fingolimod and ongoing extension studies recommends that varicella-zoster virus immune status be established in patients receiving fingolimod therapy for multiple sclerosis (MS).

Angiotensin-Converting Enzyme Inhibitors and Amyotrophic Lateral Sclerosis Risk: A Total Population–Based Case-Control Study

Abstract Full Text
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JAMA Neurol. 2015;72(1):40-48. doi:10.1001/jamaneurol.2014.3367

This total population–based case-control study found that the use of angiotensin-converting enzyme inhibitors showed a dose-dependent inverse association with amyotrophic lateral sclerosis.

Axonal Ion Channel Dysfunction in C9orf72 Familial Amyotrophic Lateral Sclerosis

Abstract Full Text
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JAMA Neurol. 2015;72(1):49-57. doi:10.1001/jamaneurol.2014.2940

This prospective study found that upregulation of persistent Na+ conductances and reduced K+ currents were evident in both c9orf72 familial amyotrophic lateral sclerosis and sporadic amyotrophic lateral sclerosis cohorts.

Higher Frequency of Certain Cancers in LRRK2 G2019S Mutation Carriers With Parkinson Disease: A Pooled Analysis

Abstract Full Text
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JAMA Neurol. 2015;72(1):58-65. doi:10.1001/jamaneurol.2014.1973

This multinational study demonstrates that LRRK2 G2019S mutation carriers have an overall increased risk of cancer, especially for hormone-related cancer and breast cancer in women.

Encephalitis of Unclear Origin Diagnosed by Brain Biopsy : A Diagnostic Challenge

Abstract Full Text
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JAMA Neurol. 2015;72(1):66-72. doi:10.1001/jamaneurol.2014.2376

This retrospective case series recommends that subsequent review of biopsy materials, ancillary testing, clinical correlation, and clinical follow-up be performed in patients with encephalitis, not otherwise specified.

Diagnostic Value of Somatosensory Evoked Potential Changes During Carotid Endarterectomy: A Systematic Review and Meta-analysis

Abstract Full Text
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JAMA Neurol. 2015;72(1):73-80. doi:10.1001/jamaneurol.2014.3071

This systematic review and meta-analysis reports that intraoperative somatosensory-evoked potential is a highly specific test in predicting neurological outcome following carotid endarterectomy. Patients with perioperative neurological deficits are 14 times more likely to have had changes in somatosensory-evoked potentials during the procedure. The use of somatosensory-evoked potentials to design prevention strategies is valuable in reducing perioperative cerebral infarctions during carotid endarterectomy.

Short Myelitis Lesions in Aquaporin-4-IgG–Positive Neuromyelitis Optica Spectrum Disorders

Abstract Full Text
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JAMA Neurol. 2015;72(1):81-87. doi:10.1001/jamaneurol.2014.2137

This original investigation reports that short transverse myelitis is not uncommon in neuromyelitis optica spectrum disorders and, when it is present, delays diagnosis/treatment. Clinical and radiological characteristics identified in this study may help select patients with short transverse myelitis who are at the highest risk for a neuromyelitis optica spectrum disorder. Short transverse myelitis does not exclude consideration of aquaporin-4-IgG testing or neuromyelitis optica spectrum disorder diagnosis.

Combined Rasagiline and Antidepressant Use in Parkinson Disease in the ADAGIO Study: Effects on Nonmotor Symptoms and Tolerability

Abstract Full Text
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JAMA Neurol. 2015;72(1):88-95. doi:10.1001/jamaneurol.2014.2472

This exploratory post hoc analysis found that the combination of rasagiline and antidepressants in patients with Parkinson disease is associated with reduced worsening of a range of nonmotor symptoms.

Case Report/Case Series

Severe Cognitive Impairment Associated With Intrathecal Antibodies to the NR1 Subunit of the N-Methyl-D-Aspartate Receptor in a Patient With Multiple Sclerosis

Abstract Full Text
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JAMA Neurol. 2015;72(1):96-99. doi:10.1001/jamaneurol.2014.1817

This case report on a woman who was diagnosed as having multiple sclerosis at age 33 years suggests that, in some cases, the occasional occurrence of severe cognitive impairment in patients with multiple sclerosis may be related to a superimposed antibody-mediated autoimmune encephalitis.

Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2015;72(1):100-105. doi:10.1001/jamaneurol.2014.2704

This case series reports clinicopathological correlations in a series of LRRK2-related Parkinson disease cases. Findings from this selected group of patients demonstrated that parkinsonian motor features can occur in the absence of Lewy bodies.

Clonal Expansion of Secondary Mitochondrial DNA Deletions Associated With Spinocerebellar Ataxia Type 28

Abstract Full Text
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JAMA Neurol. 2015;72(1):106-111. doi:10.1001/jamaneurol.2014.1753

This case series reports that AFG3L2 mutations are another important cause, but rare, of a late-onset ataxic progressive external ophthalmoplegia phenotype due to a disturbance of mitochondrial DNA maintenance.

Review

Worldwide Barriers to Organ Donation

Abstract Full Text
JAMA Neurol. 2015;72(1):112-118. doi:10.1001/jamaneurol.2014.3083

This review article finds that an urgent need exists for a global standard on the definition of brain death and donation after death by cardiac criteria to better regulate organ donation and maximize transplantation rates.

Clinical Implications of Basic Neuroscience Research

Targeted Drug Delivery to Flow-Obstructed Blood Vessels Using Mechanically Activated Nanotherapeutics

Abstract Full Text
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JAMA Neurol. 2015;72(1):119-122. doi:10.1001/jamaneurol.2014.2886

This review explores a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels by high-fluid shear stresses to selectively target drugs to sites of vascular obstruction.

Comment & Response

Peripheral Nerve Involvement in Adult and Pediatric Patients With Central Nervous System Inflammatory Disease

Abstract Full Text
JAMA Neurol. 2015;72(1):123. doi:10.1001/jamaneurol.2014.3524

Peripheral Nerve Involvement in Adult and Pediatric Patients With Central Nervous System Inflammatory Disease—Reply

Abstract Full Text
JAMA Neurol. 2015;72(1):123-124. doi:10.1001/jamaneurol.2014.3527

Intracranial Relationship Between Arterioles and Venules Size

Abstract Full Text
JAMA Neurol. 2015;72(1):124. doi:10.1001/jamaneurol.2014.3514

Intracranial Relationship Between Arterioles and Venules Size–Reply

Abstract Full Text
JAMA Neurol. 2015;72(1):124-125. doi:10.1001/jamaneurol.2014.3517

Laboratory Testing for Lyme Neuroborreliosis

Abstract Full Text
JAMA Neurol. 2015;72(1):125-126. doi:10.1001/jamaneurol.2014.3552

Laboratory Testing for Lyme Neuroborreliosis—Reply

Abstract Full Text
JAMA Neurol. 2015;72(1):126. doi:10.1001/jamaneurol.2014.3555

The Impact of Body Weight on Mortality After Stroke: The Controversy Continues

Abstract Full Text
JAMA Neurol. 2015;72(1):126-127. doi:10.1001/jamaneurol.2014.3631

The Impact of Body Weight on Mortality After Stroke—Reply

Abstract Full Text
JAMA Neurol. 2015;72(1):127-128. doi:10.1001/jamaneurol.2014.3634
Correction

eTable Removed From Supplement

Abstract Full Text
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JAMA Neurol. 2015;72(1):128. doi:10.1001/jamaneurol.2014.4130

Error in Reference

Abstract Full Text
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JAMA Neurol. 2015;72(1):128. doi:10.1001/jamaneurol.2014.4422
Peer Reviewers List

JAMA Neurology Peer Reviewers in 2014

Abstract Full Text
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JAMA Neurol. 2015;72(1):129-131. doi:10.1001/jamaneurol.2014.3667
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2015;72(1):4. doi:10.1001/jamaneurol.2014.2827
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