This viewpoint focuses on the technological advances in nucleotide sequencing and genetic engineering and on our deepening understanding of the molecular processes underlying Schwann cell–axon interactions and axonal degeneration.
Ongoing community-based clinical pathological cohort studies of aging and dementia demonstrate that brain DNA methylation in multiple AD loci is associated with AD pathologies.
A substudy of the prospective controlled Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke study indicates that golden hour thrombolysis increases with the deployment of a stroke emergency mobile unit.
This analysis of pooled data from 6 completed phase 2 and 3 studies of fingolimod and ongoing extension studies recommends that varicella-zoster virus immune status be established in patients receiving fingolimod therapy for multiple sclerosis (MS).
This total population–based case-control study found that the use of angiotensin-converting enzyme inhibitors showed a dose-dependent inverse association with amyotrophic lateral sclerosis.
This prospective study found that upregulation of persistent Na+ conductances and reduced K+ currents were evident in both c9orf72 familial amyotrophic lateral sclerosis and sporadic amyotrophic lateral sclerosis cohorts.
This multinational study demonstrates that LRRK2 G2019S mutation carriers have an overall increased risk of cancer, especially for hormone-related cancer and breast cancer in women.
This retrospective case series recommends that subsequent review of biopsy materials, ancillary testing, clinical correlation, and clinical follow-up be performed in patients with encephalitis, not otherwise specified.
This systematic review and meta-analysis reports that intraoperative somatosensory-evoked potential is a highly specific test in predicting neurological outcome following carotid endarterectomy. Patients with perioperative neurological deficits are 14 times more likely to have had changes in somatosensory-evoked potentials during the procedure. The use of somatosensory-evoked potentials to design prevention strategies is valuable in reducing perioperative cerebral infarctions during carotid endarterectomy.
This original investigation reports that short transverse myelitis is not uncommon in neuromyelitis optica spectrum disorders and, when it is present, delays diagnosis/treatment. Clinical and radiological characteristics identified in this study may help select patients with short transverse myelitis who are at the highest risk for a neuromyelitis optica spectrum disorder. Short transverse myelitis does not exclude consideration of aquaporin-4-IgG testing or neuromyelitis optica spectrum disorder diagnosis.
This exploratory post hoc analysis found that the combination of rasagiline and antidepressants in patients with Parkinson disease is associated with reduced worsening of a range of nonmotor symptoms.
This case report on a woman who was diagnosed as having multiple sclerosis at age 33 years suggests that, in some cases, the occasional occurrence of severe cognitive impairment in patients with multiple sclerosis may be related to a superimposed antibody-mediated autoimmune encephalitis.
This case series reports clinicopathological correlations in a series of LRRK2-related Parkinson disease cases. Findings from this selected group of patients demonstrated that parkinsonian motor features can occur in the absence of Lewy bodies.
This case series reports that AFG3L2 mutations are another important cause, but rare, of a late-onset ataxic progressive external ophthalmoplegia phenotype due to a disturbance of mitochondrial DNA maintenance.
This review article finds that an urgent need exists for a global standard on the definition of brain death and donation after death by cardiac criteria to better regulate organ donation and maximize transplantation rates.
This review explores a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels by high-fluid shear stresses to selectively target drugs to sites of vascular obstruction.