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August 2019 - July 1959

Decade

Year

Issue

December 2015, Vol 72, No. 12, Pages 1391-1539

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1391. doi:10.1001/jamaneurol.2014.2881
Viewpoint

Next Generation Neurology

Acute Ischemic Stroke Therapy: The Way Forward

Abstract Full Text
JAMA Neurol. 2015;72(12):1405-1406. doi:10.1001/jamaneurol.2015.2872

This Viewpoint discusses the future of thrombolysis and thrombectomy for patients with acute brain ischemia.

Next Generation Neurology

Targeting Central Nervous System B Cells in Progression of Multiple Sclerosis: Is Intrathecal Anti-CD20 a Therapeutic Option?

Abstract Full Text
JAMA Neurol. 2015;72(12):1407-1408. doi:10.1001/jamaneurol.2015.2869

This Viewpoint discusses the potential of B cells and B cell–derived products in chronic progression of multiple sclerosis.

Editorial

Dismantling Limb-Girdle Muscular Dystrophy: The Role of Whole-Exome Sequencing

Abstract Full Text
JAMA Neurol. 2015;72(12):1409-1411. doi:10.1001/jamaneurol.2015.2749

Equivalence of Glatiramer Acetate Generics With Branded Glatiramer Acetate in Efficacy and Cost for the Treatment of Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2015;72(12):1411-1413. doi:10.1001/jamaneurol.2015.2605

Cognitive Motor Dissociation Following Severe Brain Injuries

Abstract Full Text
JAMA Neurol. 2015;72(12):1413-1415. doi:10.1001/jamaneurol.2015.2899

Thrombolysis-Related Hemorrhage: Can We Make Thrombolysis Safer?

Abstract Full Text
JAMA Neurol. 2015;72(12):1416-1418. doi:10.1001/jamaneurol.2015.2900
Original Investigation

Use of Whole-Exome Sequencing for Diagnosis of Limb-Girdle Muscular Dystrophy: Outcomes and Lessons Learned

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1424-1432. doi:10.1001/jamaneurol.2015.2274

This study translates whole-exome sequencing to clinical practice for the genetic diagnosis of a large cohort of patients with limb-girdle muscular dystrophy for whom protein-based analyses and targeted Sanger sequencing failed to identify the genetic cause of their disorder.

Clinical Trial

Equivalence of Generic Glatiramer Acetate in Multiple Sclerosis: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1433-1441. doi:10.1001/jamaneurol.2015.2154

This randomized clinical trial evaluates whether generic glatiramer acetate is equivalent to the regulatory-approved brand glatiramer acetate product, as measured by imaging and clinical end points, safety, and tolerability, for treatment of relapsing-remitting multiple sclerosis.

A Thalamocortical Mechanism for the Absence of Overt Motor Behavior in Covertly Aware Patients

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1442-1450. doi:10.1001/jamaneurol.2015.2614

This case-control study examined the neural substrates and underlying networks associated with dissociation between preserved covert motor behavior and lack of overt motor behavior in behaviorally nonresponsive patients.

Treatment and Outcome of Thrombolysis-Related Hemorrhage: A Multicenter Retrospective Study

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1451-1457. doi:10.1001/jamaneurol.2015.2371

This multicenter study investigates the natural history of thrombolysis-related symptomatic intracerebral hemorrhage and in-hospital mortality, with a focus on the efficacy of various treatments used.

Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1458-1465. doi:10.1001/jamaneurol.2015.2742

This observational study of patients with multiple sclerosis examines the association between 25-dihydroxyvitamin D levels and the signs of progression of multiple sclerosis.

Association of Deep Gray Matter Damage With Cortical and Spinal Cord Degeneration in Primary Progressive Multiple Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1466-1474. doi:10.1001/jamaneurol.2015.1897

This cross-sectional study of patients with primary progressive multiple sclerosis assesses the correlation between the neurodegenerative process in the gray and white matter structures and the spinal cord and its effect on clinical disabililty.

Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1475-1483. doi:10.1001/jamaneurol.2015.2323

This longitudinal, observational study with serial brain imaging aimed to define the role of β-amyloidosis and neurodegeneration in the subsequent progression of topographic cortical structural and metabolic changes in mild cognitive impairment.

Attitudes of Research Participants and the General Public Regarding Disclosure of Alzheimer Disease Research Results

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1484-1490. doi:10.1001/jamaneurol.2015.2875

This survey reports on the attitudes of cognitively normal longitudinal aging study participants and members of the general public regarding disclosure of Alzheimer disease research results.

Clinical Trial

Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease: Two Randomized Clinical Trials and Lessons Learned

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1491-1500. doi:10.1001/jamaneurol.2015.2268

Two randomized clinical trials evaluated preladenant as an adjunct to levodopa in patients with moderate to severe Parkinson disease who were experiencing motor fluctuations.

Progression in Behavioral Variant Frontotemporal Dementia: A Longitudinal Study

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1501-1509. doi:10.1001/jamaneurol.2015.2061

This cohort study of patients with possible and probable behavioral variant frontotemporal dementia identified features of progression that may help clinicians determine the rates of progression to definite disease.

Review

The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review

Abstract Full Text
JAMA Neurol. 2015;72(12):1510-1518. doi:10.1001/jamaneurol.2015.2347

This review article describes rare localizations of peripheral neuropathy, including the appropriate diagnostic evaluation and available treatments.

Clinical Pathologic Conference

A Young Woman With Blurred Vision and Distal Paresthesias

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1519-1523. doi:10.1001/jamaneurol.2015.2390

This case report describes a patient with mild visual blurring and distal paresthesias and discusses the laboratory and radiologic findings, clinical course, and pathologic findings.

Images in Neurology

Seizures From Solving Sudoku Puzzles

Abstract Full Text
has multimedia
JAMA Neurol. 2015;72(12):1524-1526. doi:10.1001/jamaneurol.2015.2828

This case report describes a patient who had hypoxia and posthypoxic intention myoclonus and subsequently developed clonic seizures while solving sudoku puzzles.

Cerebral Straight Sinus Thrombosis: An Unusual Cause of Confusion

Abstract Full Text
JAMA Neurol. 2015;72(12):1527. doi:10.1001/jamaneurol.2015.2282

This case report describes a man with confusion and somnolence who had massive infarcts with episodes of bleeding into the thalami and basal ganglia consistent with a filling defect extending throughout the patient’s straight sinus.

Research Letter

Declining Incidence of Stroke and Dementia: Coincidence or Prevention Opportunity?

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1529-1531. doi:10.1001/jamaneurol.2015.2816

This longitudinal population-based study explores trends in declining dementia rates using health care administrative data from the Canadian Institute for Health Information for the province of Ontario, Canada.

Long-term Safety and Efficacy of Mexiletine for Patients With Skeletal Muscle Channelopathies

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1531-1533. doi:10.1001/jamaneurol.2015.2338

This retrospective review of a large skeletal muscle channelopathy patient cohort examines the long-term safety and efficacy of mexiletine for treating myotonia.

Observation

IKBKG Mutation With Incontinentia Pigmenti and Ring-Enhancing Encephalopathy

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1533-1535. doi:10.1001/jamaneurol.2015.2795

This case report describes an infant girl who presented at birth with erythematous vesicles on her hands, progressing to scaly, erythematous plaques on her head, neck, trunk, and extremities in a blaschkoid pattern.

Comment & Response

Treating In-Hospital Stroke

Abstract Full Text
JAMA Neurol. 2015;72(12):1535. doi:10.1001/jamaneurol.2015.2663

Treating In-Hospital Stroke—Reply

Abstract Full Text
JAMA Neurol. 2015;72(12):1535-1536. doi:10.1001/jamaneurol.2015.2669

Diagnosing Lymphomatosis Cerebri

Abstract Full Text
JAMA Neurol. 2015;72(12):1536. doi:10.1001/jamaneurol.2015.2672

Diagnosing Lymphomatosis Cerebri—Reply

Abstract Full Text
JAMA Neurol. 2015;72(12):1536. doi:10.1001/jamaneurol.2015.2675

Insulin Resistance and APOE ε4

Abstract Full Text
JAMA Neurol. 2015;72(12):1536-1537. doi:10.1001/jamaneurol.2015.3285
Correction

Error in Text

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1537. doi:10.1001/jamaneurol.2015.4174

Incorrect Statement in Discussion

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1537. doi:10.1001/jamaneurol.2015.4227
Book and Media Review

Review of Textbook of Stroke Medicine, 2nd ed

Abstract Full Text
JAMA Neurol. 2015;72(12):1538-1539. doi:10.1001/jamaneurol.2015.1821

Review of Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease, 5th ed

Abstract Full Text
JAMA Neurol. 2015;72(12):1538. doi:10.1001/jamaneurol.2015.2634
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2015;72(12):1398. doi:10.1001/jamaneurol.2014.2882
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