This Viewpoint report that neurology has an opportunity to influence the integrated health care system as it adapts to an aging populace, as it develops a growing awareness of the burden of neurological disease, and as it assumes financial responsibility for large groups of patients.
This cohort study found that no evidence of disease activity is difficult to sustain long term even with treatment.
This 3-year interim analysis of a phase 2 clinical trial shows that high-dose immunosuppressive therapy with autologous hematopoietic cell transplantation is effective for inducing sustained remission of active relapsing-remitting multiple sclerosis.
This whole-brain 2-dimensional FLAIR and 3-dimensional MPRAGE MR imaging study finds that brain MR imaging volumes may be important early biomarkers of risk for cognitive insult in a young, multiracial/multiethnic population. See the Editorial by Hedden.
This original investigation reports that lateral olfactory tract usher substance concentration may be useful as a possible biomarker for multiple sclerosis and that low lateral olfactory tract usher substance concentrations may be possibly involved in Nogo receptor-1 signaling, which may induce axonal degeneration in the relapse phase of relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis.
This retrospective cohort study reports that C-X-C motif chemokine 13 is a potentially useful biomarker of treatment response and outcome in Anti–N-methyl-D-aspartate receptor encephalitis.
This case-control study of isolated optic neuritis (ON) finds that nearly half of the patients with ON had antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and/or the α1 subunit of the glycine receptor.
This cross-sectional study reports that cortical cholinergic denervation is a major neurodegeneration associated with progressive declines across the spectrum of cognitive impairment in PD and typically occurs in the context of significant caudate nucleus dopaminergic denervation. Findings indicate dopaminergic and cholinergic degenerations exhibit both independent and interactive contributions to cognitive impairment in PD.
This clinic-based 2-year follow-up study reports that, as a group, GBA mutation–positive individuals show a deterioration in clinical markers consistent with the prodrome of Parkinson disease. Within this group of individual, 10% appear to be evolving at a more rapid rate.
This case-control study examines the frequency of the A673T variant in the amyloid precursor protein gene (APP) in the United States and Sweden to determine whether it will significantly contribute to risk assessment for Alzheimer disease.
This case report finds that despite adequate medical treatment of myelitis, if slow progression is seen in the follow-up clinically and radiologically, dural arteriovenous fistulas should be kept in mind in the etiopathogenesis.
This case report finds that infantile SCA7, which is often paternally transmitted, can rarely arise by maternal transmission, which has implications for diagnosis and counseling among families of patients with SCA7.
This report of a case of posterior cortical atrophy (PCA) with GRN mutations finds that analysis of the GRN gene should be performed in patients with PCA.
This review discusses the feasibility and use of a mobile stroke unit for patients with ischemic and hemorrhagic stroke.
This brief review describes the beneficial functions of endogenous neural stem cells after spinal cord injury.
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