[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.235.143.190. Please contact the publisher to request reinstatement.
[Skip to Content Landing]

May 2019 - July 1959

Decade

Year

Issue

March 2015, Vol 72, No. 3, Pages 251-368

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):251. doi:10.1001/jamaneurol.2014.2836
Viewpoint

Discovering the Brain’s Cognitive Map

Abstract Full Text
JAMA Neurol. 2015;72(3):257-258. doi:10.1001/jamaneurol.2014.4141

This Viewpoint reports on 3 neuroscientists who were recently awarded the 2014 Nobel Prize in Physiology or Medicine for their seminal research in understanding how 2 neighboring brain regions, the hippocampus and the entorhinal cortex, represent spatial information.

Deep Brain Stimulation for Parkinson Disease: The 2014 Lasker-DeBakey Clinical Medical Research Award

Abstract Full Text
JAMA Neurol. 2015;72(3):259-260. doi:10.1001/jamaneurol.2014.4109

The viewpoint reports on the 2014 Lasker-DeBakey Clinical Medical Research Award honoring Mahlon R. DeLong, MD, and Alim-Louis Benabid, MD, PhD, for their development of deep brain stimulation of the subthalamic nucleus for patients with advanced Parkinson disease.

Editorial

Cerebrospinal Fluid Total Prion Protein: A Potential In Vivo Marker of Cerebral Prion Pathology

Abstract Full Text
JAMA Neurol. 2015;72(3):261-263. doi:10.1001/jamaneurol.2014.4078

Carotid Stenting—Why Treating an Artery May Not Treat the Patient

Abstract Full Text
JAMA Neurol. 2015;72(3):263-264. doi:10.1001/jamaneurol.2014.4142

The Translational Journey of Brain β-Amyloid Imaging: From Positron Emission Tomography to Autopsy to Clinic

Abstract Full Text
JAMA Neurol. 2015;72(3):265-266. doi:10.1001/jamaneurol.2014.4143
Original Investigation

Association of Cerebrospinal Fluid Prion Protein Levels and the Distinction Between Alzheimer Disease and Creutzfeldt-Jakob Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):267-275. doi:10.1001/jamaneurol.2014.4068

This retrospective study reports that in unusual phenotypes of Alzheimer disease, especially cases presenting a biological ambiguity suggesting Creutzfeldt-Jakob disease, the determination of total cerebrospinal fluid prion protein levels increased diagnostic accuracy. The use of total cerebrospinal fluid prion protein levels may be beneficial in clinical practice in addition to the current classic biomarkers.

Outcomes After Carotid Artery Stenting in Medicare Beneficiaries, 2005 to 2009

Abstract Full Text
free access has audio
JAMA Neurol. 2015;72(3):276-286. doi:10.1001/jamaneurol.2014.3638

This observational study finds that competing risks may limit the benefits of carotid artery stenting in certain Medicare beneficiaries, particularly among older and symptomatic patients who have higher periprocedural and long-term mortality risks. See the Editorial by Alberts.

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):287-294. doi:10.1001/jamaneurol.2014.4144

This multi-imaging study reports that flutemetamol injection labeled with radioactive 18 is safe and that in vivo detection of brain amyloid β plaque density may increase diagnostic accuracy in cognitively impaired patients.

Criminal Behavior in Frontotemporal Dementia and Alzheimer Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):295-300. doi:10.1001/jamaneurol.2014.3781

Criminal behavior is more common in patients with behavioral variant of frontotemporal dementia and semantic variant of primary progressive aphasia than in those with Alzheimer disease and is more likely to be an early manifestation of the disorder.

Cerebral Microbleeds and Early Recurrent Stroke After Transient Ischemic Attack: Results From the Korean Transient Ischemic Attack Expression Registry

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):301-308. doi:10.1001/jamaneurol.2014.3958

This multicenter prospective cohort study found that immediate and optimal management modifies the risk of recurrent stroke after transient ischemic attack.

Indirect Measures of Arterial Stiffness and Cognitive Performance in Individuals Without Traditional Vascular Risk Factors or Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):309-315. doi:10.1001/jamaneurol.2014.3873

This survey of older participants in 2 cycles of the NHANES finds that those without clinical atherosclerotic disease had poorer cognitive performance associated with an ankle brachial index greater than 1.30 and increased blood pressure variability.

Associations Between Biomarkers and Age in the Presenilin 1 E280A Autosomal Dominant Alzheimer Disease Kindred: A Cross-sectional Study

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):316-324. doi:10.1001/jamaneurol.2014.3314

This cross-sectional study provides additional information about the course of different AD biomarkers in the preclinical and clinical stages of autosomal dominant AD.

Factors Associated With the Onset and Persistence of Post–Lumbar Puncture Headache

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):325-332. doi:10.1001/jamaneurol.2014.3974

This retrospective observational study finds that factors acutely lowering CSF pressure (eg, seated positioning or extracting very high volumes of CSF) may be associated with transient post−dural puncture headache, without increasing rates of persistent headache or therapeutic blood patch.

Association of Pituitary Adenylate Cyclase–Activating Polypeptide With Cognitive Decline in Mild Cognitive Impairment Due to Alzheimer Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):333-339. doi:10.1001/jamaneurol.2014.3625

This postmortem study reports that deficits in pituitary adenylate cyclase–activating polypeptide are associated with clinical severity in the mild cognitive impairment and dementia stages of Alzheimer disease (AD).

Cognitive Resilience to Apolipoprotein E ε4: Contributing Factors in Black and White Older Adults

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):340-348. doi:10.1001/jamaneurol.2014.3978

This prospective cohort study finds that enhancement of cognitive reserve and improvement of other psychosocial and health factors are possible targets to promote cognitive resilience in apolipoprotein E ε4 carriers.

Review

Advantages and Limitations of Teleneurology

Abstract Full Text
JAMA Neurol. 2015;72(3):349-354. doi:10.1001/jamaneurol.2014.3844

This review shows that teleneurology provides neurological expertise to rural areas with limited availability of neurologists and improves care for patients with difficulty traveling owing to neurological disease.

Clinical Implications of Basic Neuroscience Research

Inflammation and Neuroprotection in Traumatic Brain Injury

Abstract Full Text
free access has multimedia
JAMA Neurol. 2015;72(3):355-362. doi:10.1001/jamaneurol.2014.3558

This review article found that the central nervous system inflammatory reaction to brain injury can be deleterious or beneficial, with individual cell populations possessing the ability to be neurotoxic or neuroprotective.

Clinical Pathologic Conference

A 20-Year-Old Man With Back Pain and Lower Extremity Weakness

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):363-366. doi:10.1001/jamaneurol.2014.3833

This Clinical Pathologic Conference discusses the differential diagnosis, pathological findings, and diagnosis of a 20-year-old man with low back pain and progressive lower extremity weakness.

Comment & Response

Deep Brain Stimulation for Parkinson Disease in Elderly Individuals

Abstract Full Text
JAMA Neurol. 2015;72(3):367. doi:10.1001/jamaneurol.2014.4216

Deep Brain Stimulation for Parkinson Disease in Elderly Individuals

Abstract Full Text
JAMA Neurol. 2015;72(3):367-368. doi:10.1001/jamaneurol.2014.4222

Deep Brain Stimulation for Parkinson Disease in Elderly Individuals—Reply

Abstract Full Text
JAMA Neurol. 2015;72(3):368. doi:10.1001/jamaneurol.2014.4219
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2015;72(3):252. doi:10.1001/jamaneurol.2014.2837
×