This Viewpoint reports on 3 neuroscientists who were recently awarded the 2014 Nobel Prize in Physiology or Medicine for their seminal research in understanding how 2 neighboring brain regions, the hippocampus and the entorhinal cortex, represent spatial information.
The viewpoint reports on the 2014 Lasker-DeBakey Clinical Medical Research Award honoring Mahlon R. DeLong, MD, and Alim-Louis Benabid, MD, PhD, for their development of deep brain stimulation of the subthalamic nucleus for patients with advanced Parkinson disease.
This retrospective study reports that in unusual phenotypes of Alzheimer disease, especially cases presenting a biological ambiguity suggesting Creutzfeldt-Jakob disease, the determination of total cerebrospinal fluid prion protein levels increased diagnostic accuracy. The use of total cerebrospinal fluid prion protein levels may be beneficial in clinical practice in addition to the current classic biomarkers.
This observational study finds that competing risks may limit the benefits of carotid artery stenting in certain Medicare beneficiaries, particularly among older and symptomatic patients who have higher periprocedural and long-term mortality risks. See the Editorial by Alberts.
This multi-imaging study reports that flutemetamol injection labeled with radioactive 18 is safe and that in vivo detection of brain amyloid β plaque density may increase diagnostic accuracy in cognitively impaired patients.
Criminal behavior is more common in patients with behavioral variant of frontotemporal dementia and semantic variant of primary progressive aphasia than in those with Alzheimer disease and is more likely to be an early manifestation of the disorder.
This multicenter prospective cohort study found that immediate and optimal management modifies the risk of recurrent stroke after transient ischemic attack.
This survey of older participants in 2 cycles of the NHANES finds that those without clinical atherosclerotic disease had poorer cognitive performance associated with an ankle brachial index greater than 1.30 and increased blood pressure variability.
This cross-sectional study provides additional information about the course of different AD biomarkers in the preclinical and clinical stages of autosomal dominant AD.
This retrospective observational study finds that factors acutely lowering CSF pressure (eg, seated positioning or extracting very high volumes of CSF) may be associated with transient post−dural puncture headache, without increasing rates of persistent headache or therapeutic blood patch.
This postmortem study reports that deficits in pituitary adenylate cyclase–activating polypeptide are associated with clinical severity in the mild cognitive impairment and dementia stages of Alzheimer disease (AD).
This prospective cohort study finds that enhancement of cognitive reserve and improvement of other psychosocial and health factors are possible targets to promote cognitive resilience in apolipoprotein E ε4 carriers.
This review shows that teleneurology provides neurological expertise to rural areas with limited availability of neurologists and improves care for patients with difficulty traveling owing to neurological disease.
This review article found that the central nervous system inflammatory reaction to brain injury can be deleterious or beneficial, with individual cell populations possessing the ability to be neurotoxic or neuroprotective.
This Clinical Pathologic Conference discusses the differential diagnosis, pathological findings, and diagnosis of a 20-year-old man with low back pain and progressive lower extremity weakness.
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