This Viewpoint reports that the blood-brain barrier is thought to restrict access of therapeutic agents that may otherwise be effective against central nervous system diseases. However, there is controversy in the neurotherapeutics community about the degree to which this hypothesis is true.
This viewpoint discusses the measurement of carotid plaque burden in determining cardiovascular risk factors.
This genome-wide association study provides insights into aberrant cellular mechanisms responsible for myasthenia gravis.
This retrospective data analysis finds that switching from injectable immunomodulators to fingolimod is associated with fewer relapses, more favorable disability outcomes, and greater treatment persistence compared with switching to another injectable preparation following on-treatment activity of multiple sclerosis.
This genotyping study finds that low-frequency coding variants with intermediate effect size may account for a significant fraction of the genetic susceptibility to AD and frontotemporal dementia.
This retrospective analysis reports treatment complications and short-term outcomes in patients with mild ischemic stroke treated with intravenous thrombolysis.
The systematic review and meta-analysis suggests that repetitive transcranial magnetic stimulation improves motor symptoms for patients with Parkinson disease.
This study identifies the deep-intronic mutation, which acts as a gene trap. This second-most common adult polyglucosan body disease mutation now explains another founder effect in all Ashkenazi-Jewish cases.
This longitudinal study found the Cognitive Function Instrument to be an informative potential outcome measure that provides insight into functional abilities at the earliest stages of Alzheimer disease.
This review found that nonmydriatic ocular fundus photography has advantages over direct ophthalmoscopy that likely outweigh its associated costs.
This systematic literature review provides a minimum data set to use for clinical and imaging data collection in primary familial brain calcification.
This study concludes that information on the causative events of Huntington disease might help identify biomarkers that could be used to facilitate clinical trials.