This Viewpoint discusses the potential antiviral efficacy of fluoxetine in patients with enterovirus-D68–associated acute flaccid myelitis.
This Viewpoint discusses the role the hippocampus may play in dementia.
This Viewpoint evaluates the ways in which individualized evaluation in patients with Alzheimer disease may lead to more effective treatments.
This preoperative and postoperative study found that subthalamic nucleus deep brain stimulation improves pain associated with Parkinson disease.
This cross-sectional observational study finds that male sex is associated with worse memory and adjusted hippocampal volume among cognitively normal individuals, while APOE ε4 is not. See the Editorial by DeCarli.
This prospective longitudinal study reports that elevated cerebrospinal fluid vascular endothelial growth factor was associated with more optimal brain aging in vivo. Nelson and Jicha provide a related Article .
This cohort study provides prospective evidence of reduced cerebral blood flow in human concussion and subsequent recovery.
This longitudinal cohort study reports that in patients with Alzheimer disease, the presence of nonlobar microbleeds was associated with an increased risk for cardiovascular events and cardiovascular mortality.
This study reports that pulse pressure, an index of vascular aging, was associated with neurodegenerative change prior to the onset of dementia across a broad age range and that in very old participants, higher pulse pressure was associated with cerebral amyloidosis in the presence of neurodegeneration and more rapid progression to dementia.
This longitudinal cohort study finds that baseline cerebrospinal fluid Aβ42 levels in the lower part of the reference range are strongly associated with future Aβ positivity
This study expands the genetics of autosomal dominant hereditary spastic paraplegia and links mutation in CPT1C with a human disease.
This longitudinal clinical cohort study reports that the association between cerebrospinal fluid and positron emission tomographic amyloid biomarkers is limited to a middle range of values, is modified by the APOE genotype, and is absent for longitudinal changes and suggests that both biomarkers measure different aspects of Alzheimer disease Aβ pathology.
This literature review finds that increased use of new tools and approaches in future clinical trials can enhance their design, improve assessment, and engage participants in evaluation of novel therapies.
This systematic review examined survival data in elderly patients with glioblastoma being treated with temozolomide therapy alone vs radiotherapy alone.
This retrospective case series describes the clinical, histochemical, molecular, and imaging findings of 4 human immunodeficiency virus–infected patients with mitochondrial myopathy that developed years after exposure to potentially mitochondrially toxic nucleoside analog reverse transcriptase inhibitors.
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