Yu Jin Jung, MD; Han-Joon Kim, MD, PhD; Beom S. Jeon, MD, PhD; et al.
free access
JAMA Neurol. 2015;72(5):504-510. doi:10.1001/jamaneurol.2015.8
This preoperative and postoperative study found that subthalamic nucleus deep brain stimulation improves pain associated with Parkinson disease.
Clifford R. Jack Jr, MD; Heather J. Wiste, BA; Stephen D. Weigand, MS; et al.
free access
JAMA Neurol. 2015;72(5):511-519. doi:10.1001/jamaneurol.2014.4821
This cross-sectional observational study finds that male sex is associated with worse memory and adjusted hippocampal volume among cognitively normal individuals, while APOE ε4 is not. See the Editorial by DeCarli.
Timothy J. Hohman, PhD; Susan P. Bell, MBBS, MSCI; Angela L. Jefferson, PhD; et al.
free access
JAMA Neurol. 2015;72(5):520-529. doi:10.1001/jamaneurol.2014.4761
This prospective longitudinal study reports that elevated cerebrospinal fluid vascular endothelial growth factor was associated with more optimal brain aging in vivo. Nelson and Jicha provide a related Article .
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Editorial
Cerebrospinal Fluid Vascular Endothelial Growth Factor
Peter T. Nelson, MD, PhD; Gregory A. Jicha, MD, PhD
JAMA Neurol
Timothy B. Meier, PhD; Patrick S. F. Bellgowan, PhD; Rashmi Singh, PhD; et al.
free access
has audio
JAMA Neurol. 2015;72(5):530-538. doi:10.1001/jamaneurol.2014.4778
This cohort study provides prospective evidence of reduced cerebral blood flow in human concussion and subsequent recovery.
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Audio Author Interview:
Cerebral Blood Flow Following Sports-Related Concussion (JAMA Neurology)
Marije R. Benedictus, MSc; Niels D. Prins, PhD; Jeroen D. C. Goos, PhD; et al.
free access
JAMA Neurol. 2015;72(5):539-545. doi:10.1001/jamaneurol.2015.14
This longitudinal cohort study reports that in patients with Alzheimer disease, the presence of nonlobar microbleeds was associated with an increased risk for cardiovascular events and cardiovascular mortality.
Daniel A. Nation, PhD; Emily C. Edmonds, PhD; Katherine J. Bangen, PhD; et al.
free access
JAMA Neurol. 2015;72(5):546-553. doi:10.1001/jamaneurol.2014.4477
This study reports that pulse pressure, an index of vascular aging, was associated with neurodegenerative change prior to the onset of dementia across a broad age range and that in very old participants, higher pulse pressure was associated with cerebral amyloidosis in the presence of neurodegeneration and more rapid progression to dementia.
Niklas Mattsson, MD, PhD; Philip S. Insel, MSc; Michael Donohue, PhD; et al.
free access
JAMA Neurol. 2015;72(5):554-560. doi:10.1001/jamaneurol.2014.4530
This longitudinal cohort study finds that baseline cerebrospinal fluid Aβ42 levels in the lower part of the reference range are strongly associated with future Aβ positivity
Carlo Rinaldi, MD, PhD; Thomas Schmidt, PhD; Alan J. Situ, BS; et al.
free access
JAMA Neurol. 2015;72(5):561-570. doi:10.1001/jamaneurol.2014.4769
This study expands the genetics of autosomal dominant hereditary spastic paraplegia and links mutation in CPT1C with a human disease.
Jon B. Toledo, MD; Maria Bjerke, PhD; Xiao Da, MS; et al.
free access
JAMA Neurol. 2015;72(5):571-581. doi:10.1001/jamaneurol.2014.4829
This longitudinal clinical cohort study reports that the association between cerebrospinal fluid and positron emission tomographic amyloid biomarkers is limited to a middle range of values, is modified by the APOE genotype, and is absent for longitudinal changes and suggests that both biomarkers measure different aspects of Alzheimer disease Aβ pathology.