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May 2019 - July 1959

Decade

Year

Issue

May 2015, Vol 72, No. 5, Pages 491-608

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):491. doi:10.1001/jamaneurol.2014.2846
Viewpoint

Rationale for the Evaluation of Fluoxetine in the Treatment of Enterovirus D68-Associated Acute Flaccid Myelitis

Abstract Full Text
JAMA Neurol. 2015;72(5):493-494. doi:10.1001/jamaneurol.2014.4625

This Viewpoint discusses the potential antiviral efficacy of fluoxetine in patients with enterovirus-D68–associated acute flaccid myelitis.

Vascular Plasticity and Cognition During Normal Aging and Dementia

Abstract Full Text
JAMA Neurol. 2015;72(5):495-496. doi:10.1001/jamaneurol.2014.4636

This Viewpoint discusses the role the hippocampus may play in dementia.

Personalized Medicine for Effective Alzheimer Disease Treatment

Abstract Full Text
JAMA Neurol. 2015;72(5):497-498. doi:10.1001/jamaneurol.2014.3445

This Viewpoint evaluates the ways in which individualized evaluation in patients with Alzheimer disease may lead to more effective treatments.

Editorial

Deep Brain Stimulation of the Subthalamic Nucleus: Taking the Ouch Out of Parkinson Disease

Abstract Full Text
JAMA Neurol. 2015;72(5):499-500. doi:10.1001/jamaneurol.2015.36

A Call for New Thoughts About What Might Influence Human Brain Aging: Aging, Apolipoprotein E, and Amyloid

Abstract Full Text
JAMA Neurol. 2015;72(5):500-502. doi:10.1001/jamaneurol.2015.33

Cerebrospinal Fluid Vascular Endothelial Growth Factor

Abstract Full Text
JAMA Neurol. 2015;72(5):502-503. doi:10.1001/jamaneurol.2015.34
Original Investigation

An 8-Year Follow-up on the Effect of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):504-510. doi:10.1001/jamaneurol.2015.8

This preoperative and postoperative study found that subthalamic nucleus deep brain stimulation improves pain associated with Parkinson disease.

Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):511-519. doi:10.1001/jamaneurol.2014.4821

This cross-sectional observational study finds that male sex is associated with worse memory and adjusted hippocampal volume among cognitively normal individuals, while APOE ε4 is not. See the Editorial by DeCarli.

The Role of Vascular Endothelial Growth Factor in Neurodegeneration and Cognitive Decline: Exploring Interactions With Biomarkers of Alzheimer Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):520-529. doi:10.1001/jamaneurol.2014.4761

This prospective longitudinal study reports that elevated cerebrospinal fluid vascular endothelial growth factor was associated with more optimal brain aging in vivo. Nelson and Jicha provide a related Article .

Recovery of Cerebral Blood Flow Following Sports-Related Concussion

Abstract Full Text
free access has audio
JAMA Neurol. 2015;72(5):530-538. doi:10.1001/jamaneurol.2014.4778

This cohort study provides prospective evidence of reduced cerebral blood flow in human concussion and subsequent recovery.

Microbleeds, Mortality, and Stroke in Alzheimer Disease: The MISTRAL Study

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):539-545. doi:10.1001/jamaneurol.2015.14

This longitudinal cohort study reports that in patients with Alzheimer disease, the presence of nonlobar microbleeds was associated with an increased risk for cardiovascular events and cardiovascular mortality.

Pulse Pressure in Relation to Tau-Mediated Neurodegeneration, Cerebral Amyloidosis, and Progression to Dementia in Very Old Adults

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):546-553. doi:10.1001/jamaneurol.2014.4477

This study reports that pulse pressure, an index of vascular aging, was associated with neurodegenerative change prior to the onset of dementia across a broad age range and that in very old participants, higher pulse pressure was associated with cerebral amyloidosis in the presence of neurodegeneration and more rapid progression to dementia.

Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):554-560. doi:10.1001/jamaneurol.2014.4530

This longitudinal cohort study finds that baseline cerebrospinal fluid Aβ42 levels in the lower part of the reference range are strongly associated with future Aβ positivity

Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):561-570. doi:10.1001/jamaneurol.2014.4769

This study expands the genetics of autosomal dominant hereditary spastic paraplegia and links mutation in CPT1C with a human disease.

Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):571-581. doi:10.1001/jamaneurol.2014.4829

This longitudinal clinical cohort study reports that the association between cerebrospinal fluid and positron emission tomographic amyloid biomarkers is limited to a middle range of values, is modified by the APOE genotype, and is absent for longitudinal changes and suggests that both biomarkers measure different aspects of Alzheimer disease Aβ pathology.

Review

Novel Methods and Technologies for 21st-Century Clinical Trials: A Review

Abstract Full Text
JAMA Neurol. 2015;72(5):582-588. doi:10.1001/jamaneurol.2014.4524

This literature review finds that increased use of new tools and approaches in future clinical trials can enhance their design, improve assessment, and engage participants in evaluation of novel therapies.

Clinical Implications of Basic Neuroscience Research

Treatment of Elderly Patients With Glioblastoma: A Systematic Evidence-Based Analysis

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):589-596. doi:10.1001/jamaneurol.2014.3739

This systematic review examined survival data in elderly patients with glioblastoma being treated with temozolomide therapy alone vs radiotherapy alone.

Images in Neurology

Diagnosis of Cervical Artery Dissection Using 3-T Magnetic Resonance Imaging

Abstract Full Text
JAMA Neurol. 2015;72(5):600-601. doi:10.1001/jamaneurol.2014.4589
JAMA Neurology Clinical Challenge

Personality Change and Gait Dysfunction

Abstract Full Text
JAMA Neurol. 2015;72(5):597-598. doi:10.1001/jamaneurol.2014.3668
Research Letter

Clinical and Pathological Features of Mitochondrial DNA Deletion Disease Following Antiretroviral Treatment

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):603-605. doi:10.1001/jamaneurol.2015.0150

This retrospective case series describes the clinical, histochemical, molecular, and imaging findings of 4 human immunodeficiency virus–infected patients with mitochondrial myopathy that developed years after exposure to potentially mitochondrially toxic nucleoside analog reverse transcriptase inhibitors.

Comment & Response

Association Between Vaccines and Neuroinflammation: Time, Risks, and Benefits

Abstract Full Text
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.71

Association Between Vaccines and Neuroinflammation—Reply

Abstract Full Text
JAMA Neurol. 2015;72(5):605. doi:10.1001/jamaneurol.2015.75

Defining the Eye-of-the-Tiger Sign

Abstract Full Text
JAMA Neurol. 2015;72(5):606. doi:10.1001/jamaneurol.2015.0144

Defining the Eye-of-the-Tiger Sign—Reply

Abstract Full Text
JAMA Neurol. 2015;72(5):606-607. doi:10.1001/jamaneurol.2015.0147

Statin Use During Hospitalization for Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2015;72(5):607. doi:10.1001/jamaneurol.2015.0131

Statin Use During Hospitalization for Intracerebral Hemorrhage—Reply

Abstract Full Text
JAMA Neurol. 2015;72(5):607-608. doi:10.1001/jamaneurol.2015.0134
Correction

Error in Figure Legend

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):608. doi:10.1001/jamaneurol.2015.0382

Typographical Errors in Figure

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):608. doi:10.1001/jamaneurol.2015.0528
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2015;72(5):492. doi:10.1001/jamaneurol.2014.2847
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