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October 2018 - July 1959




July 2015, Vol 72, No. 7, Pages 735-836

In This Issue of JAMA Neurology


Abstract Full Text
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JAMA Neurol. 2015;72(7):735. doi:10.1001/jamaneurol.2014.2856

The Patient Protection and Affordable Care Act and Chronic Neurological IllnessesBenefits and Challenges

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JAMA Neurol. 2015;72(7):739-740. doi:10.1001/jamaneurol.2015.0273

This Viewpoint discusses the costs associated with care for chronic neurological illnesses for patients with health insurance exchange plans, established through the Patient Protection and Affordable Care Act.

Advances in Muscular Dystrophies

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JAMA Neurol. 2015;72(7):741-742. doi:10.1001/jamaneurol.2014.4621

Clinical Trials of Therapies for Amyotrophic Lateral SclerosisOne Size Does Not Fit All

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JAMA Neurol. 2015;72(7):743-744. doi:10.1001/jamaneurol.2014.4275

This Viewpoint discusses amyotrophic lateral sclerosis as a syndrome rather than a single disease that requires varied diagnostic and therapeutic approaches.


JAMA Neurology Clinical ChallengeCall for Papers

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JAMA Neurol. 2015;72(7):745. doi:10.1001/jamaneurol.2015.0802

In-Hospital StrokeHidden in Plain Sight

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JAMA Neurol. 2015;72(7):746. doi:10.1001/jamaneurol.2015.0370

Targeting the Interleukin 6 Receptor to Treat Neuromyelitis Optica

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JAMA Neurol. 2015;72(7):747-748. doi:10.1001/jamaneurol.2015.0579
Original Investigation

Care and Outcomes of Patients With In-Hospital Stroke

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JAMA Neurol. 2015;72(7):749-755. doi:10.1001/jamaneurol.2015.0284

This prospective cohort study examines stroke care delivery and outcomes for patients with in-hospital vs community-onset stroke.

Long-term Therapy With Interleukin 6 Receptor Blockade in Highly Active Neuromyelitis Optica Spectrum Disorder

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JAMA Neurol. 2015;72(7):756-763. doi:10.1001/jamaneurol.2015.0533

This retrospective observational study evaluates the long-term safety and efficacy of tocilizumab, a humanized antibody targeting the interleukin 6 receptor, in 8 female patients with neuromyelitis optica (NMO) and NMO spectrum disorder. See the Editorial by Vincent.

Clinical Trial

Standard vs Modified Antiplatelet Preparation for Preventing Thromboembolic Events in Patients With High On-Treatment Platelet Reactivity Undergoing Coil Embolization for an Unruptured Intracranial AneurysmA Randomized Clinical Trial

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JAMA Neurol. 2015;72(7):764-772. doi:10.1001/jamaneurol.2015.0654

This randomized clinical trial evaluates the effect of standard vs modified antiplatelet preparation in patients with high on-treatment platelet reactivity undergoing coil embolization in unruptured aneurysms.

Imaging Correlates of Memory and Concussion History in Retired National Football League Athletes

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JAMA Neurol. 2015;72(7):773-780. doi:10.1001/jamaneurol.2015.0206

This retrospective cohort study reports that prior concussion resulting in loss of consciousness is a risk factor for increased hippocampal atrophy and the development of MCI. In individuals with MCI, hippocampal volume loss appears more prevalent among those with a history of concussion.

Rare and Coding Region Genetic Variants Associated With Risk of Ischemic StrokeThe NHLBI Exome Sequence Project

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JAMA Neurol. 2015;72(7):781-788. doi:10.1001/jamaneurol.2015.0582

This genome-wide association study identifies 2 novel genes, PDE4DIP and ACOT4, that are associated with an increased risk for ischemic stroke.

Clinical Features of Alzheimer Disease With and Without Lewy Bodies

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JAMA Neurol. 2015;72(7):789-796. doi:10.1001/jamaneurol.2015.0606

This retrospective study suggests that Lewy body–related phenotypes within Alzheimer disease may be useful in distinguishing the presence of comorbid Lewy body pathology.

A Novel Mutation in ELOVL4 Leading to Spinocerebellar Ataxia (SCA) With the Hot Cross Bun Sign but Lacking ErythrokeratodermiaA Broadened Spectrum of SCA34

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JAMA Neurol. 2015;72(7):797-805. doi:10.1001/jamaneurol.2015.0610

This genetic study identifies the causative gene of spinocerebellar ataxia in 2 Japanese families with distinct neurological symptoms and radiological presentations.

Risk of Neuropathy Among 28 232 Patients With Biopsy-Verified Celiac Disease

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JAMA Neurol. 2015;72(7):806-811. doi:10.1001/jamaneurol.2015.0475

This population-based study showed that celiac disease was associated with a 2.5-fold increased risk of later neuropathy, including chronic inflammatory demyelinating neuropathy, autonomic neuropathy, and mononeuritis multiplex.

Special Communication

The Future of Research in Myasthenia

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JAMA Neurol. 2015;72(7):812-814. doi:10.1001/jamaneurol.2014.4740

This Special Communication reports on the latest research in myasthenia, which results from dysfunction of the neuromuscular synapse (ie, the neuromuscular junction), causing clinical “fatigue” that is defined as muscle weakness that worsens with muscle use and improves with rest.


Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

Abstract Full Text
JAMA Neurol. 2015;72(7):815-822. doi:10.1001/jamaneurol.2015.0248

This review summarizes the literature on advanced quantitative imaging measures reported for patients with neuromyelitis optica spectrum disorder, including proton magnetic resonance spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative magnetic resonance volumetry, and ultrahigh-field strength magnetic resonance imaging.

Clinical Implications of Basic Neuroscience Research

Neuroelectronics and BioopticsClosed-Loop Technologies in Neurological Disorders

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JAMA Neurol. 2015;72(7):823-829. doi:10.1001/jamaneurol.2015.0608

This article discusses how advances in experimental closed-loop systems hold promise for improved clinical benefit in patients with neurological disorders.

Images in Neurology

Eight-and-a-Half Syndrome

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JAMA Neurol. 2015;72(7):830. doi:10.1001/jamaneurol.2015.0255

Papilledema From Intraventricular Neurocysticercosis

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JAMA Neurol. 2015;72(7):831. doi:10.1001/jamaneurol.2015.0470

This case report describes a woman with neurocysticercosis manifesting as blurry vision, tinnitus, and multiple posterior fossa cysts requiring surgical drainage.


Recovery From Locked-in Syndrome

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JAMA Neurol. 2015;72(7):832-833. doi:10.1001/jamaneurol.2015.0479

This case report describes a 22-year-old man who presented with an acute basilar artery occlusion.

Corticosteroid-Induced Paraplegia—A Diagnostic Clue for Spinal Dural Arterial Venous Fistula

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JAMA Neurol. 2015;72(7):833-834. doi:10.1001/jamaneurol.2015.0757

This case report describes a man in his 60s who presented with groin numbness, incomplete bladder emptying, and leg weakness.

Comment & Response

Factors Contributing to Post–Lumbar Puncture Headache

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JAMA Neurol. 2015;72(7):834-835. doi:10.1001/jamaneurol.2015.0694

No Evidence of Disease Activity in Multiple Sclerosis

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JAMA Neurol. 2015;72(7):835-836. doi:10.1001/jamaneurol.2015.0587

Factors Contributing to the Post–Lumbar Puncture Headache—Reply

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JAMA Neurol. 2015;72(7):835. doi:10.1001/jamaneurol.2015.0691
JAMA Neurology Masthead

JAMA Neurology

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JAMA Neurol. 2015;72(7):737. doi:10.1001/jamaneurol.2014.2857