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July 2019 - July 1959

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Issue

August 2015, Vol 72, No. 8, Pages 847-951

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):847. doi:10.1001/jamaneurol.2014.2861
Viewpoint

The Future of Research in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2015;72(8):853-854. doi:10.1001/jamaneurol.2015.0270

This Viewpoint discusses new areas of focus in multiple sclerosis, including progressive multiple sclerosis, contributors to multiple sclerosis, and learning from the real world.

The Importance of Lesbian, Gay, Bisexual, and Transgender Health in Neurology: What’s in a Name?

Abstract Full Text
JAMA Neurol. 2015;72(8):855-856. doi:10.1001/jamaneurol.2015.0226

This Viewpoint explores the challenges and potential disparities of the lesbian, gay, bisexual, and trangender community in neurological care.

Heritability of Amyotrophic Lateral Sclerosis: Insights From Disparate Numbers

Abstract Full Text
JAMA Neurol. 2015;72(8):857-858. doi:10.1001/jamaneurol.2014.4049

This Viewpoint discusses different techniques for estimating the heritability of amyotrophic lateral sclerosis.

Editorial

Clinical Determinants of Progression of Parkinson Disease: Predicting Prognosis by Subtype

Abstract Full Text
JAMA Neurol. 2015;72(8):859-860. doi:10.1001/jamaneurol.2015.1067

Association of Paraneoplastic Neurological Disorders With Glutamic Acid Decarboxylase Antibodies

Abstract Full Text
JAMA Neurol. 2015;72(8):861-862. doi:10.1001/jamaneurol.2015.1068
Original Investigation

New Clinical Subtypes of Parkinson Disease and Their Longitudinal Progression: A Prospective Cohort Comparison With Other Phenotypes

Abstract Full Text
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JAMA Neurol. 2015;72(8):863-873. doi:10.1001/jamaneurol.2015.0703

This cohort study, using a data-driven cluster analysis on a broad spectrum of motor and nonmotor features, found 3 distinct phenotypes of Parkinson disease consisting of mainly motor/slow progression, intermediate, and diffuse/malignant subtypes.

Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):874-881. doi:10.1001/jamaneurol.2015.0749

This case series study describes the clinical and immunological features of patients with paraneoplastic neurological syndromes and glutamic acid decarboxylase antibodies.

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):882-888. doi:10.1001/jamaneurol.2015.0941

This cohort study uses positron emission tomography to determine whether patients with temporal lobe epilepsy have increased neuroinflammation as shown by translocator protein expression.

Impaired Synaptic Development, Maintenance, and Neuromuscular Transmission in LRP4-Related Myasthenia

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):889-896. doi:10.1001/jamaneurol.2015.0853

This study characterized the clinical, structural, electrophysiologic, and genetic features of a congenital myasthenic syndrome, identified the disease gene and mutation, confirmed pathogenicity of the mutation by expression studies, and instituted optimal pharmacotherapy.

Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):897-904. doi:10.1001/jamaneurol.2015.0993

This observational study investigates the associations between multiple sclerosis disability and disease type with lower thoracic cord gray matter and white matter areas using phase sensitive inversion recovery magnetic resonance imaging at 3T, as well as compares these relationships with those obtained at upper cervical levels.

Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Study

Abstract Full Text
free access
JAMA Neurol. 2015;72(8):905-911. doi:10.1001/jamaneurol.2015.0910

This population-based case-control study investigates the risk of amyotrophic lateral sclerosis associated with diabetes and obesity among Danish individuals.

Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study

Abstract Full Text
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JAMA Neurol. 2015;72(8):912-919. doi:10.1001/jamaneurol.2015.1099

This cross-sectional study reports that children at genetic risk for autosomal dominant Alzheimer disease have functional and structural brain changes and abnormal levels of plasma amyloid-β 1-42.

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Abstract Full Text
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JAMA Neurol. 2015;72(8):920-927. doi:10.1001/jamaneurol.2015.0979

This study reports that ApoE4, TREM2 R47H, and rare variants in other genes, such as UNC5C D353N, are likely responsible for the notable occurrence of Alzheimer disease in a large family with late-onset disease.

Review

Progress in Intravenous Thrombolytic Therapy for Acute Stroke

Abstract Full Text
JAMA Neurol. 2015;72(8):928-934. doi:10.1001/jamaneurol.2015.0835

This review traces the development of intravenous thrombolysis to date, considers the shortcomings of alteplase, and examines alternative thrombolytic approaches currently in the pipeline, including the role of neuroimaging and the possibility of combination therapies.

Images in Neurology

Paraparesis From Upper Cervical Spinal Dural Arteriovenous Fistula

Abstract Full Text
JAMA Neurol. 2015;72(8):936-937. doi:10.1001/jamaneurol.2015.0864

Leukemic Polyradiculopathy Due to Blastic Plasmacytoid Dendritic Cell Neoplasm

Abstract Full Text
JAMA Neurol. 2015;72(8):938-939. doi:10.1001/jamaneurol.2015.0830

Dejerine Hand Phenomenon

Abstract Full Text
has multimedia
JAMA Neurol. 2015;72(8):940. doi:10.1001/jamaneurol.2015.0590
Research Letter

A New ELOVL4 Mutation in a Case of Spinocerebellar Ataxia With Erythrokeratodermia

Abstract Full Text
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JAMA Neurol. 2015;72(8):942-943. doi:10.1001/jamaneurol.2015.0888

This case report describes a man in his 30s who developed a progressive gait disorder in his mid-20s.

Observation

Successful Antiviral Treatment of Giant Cell Arteritis and Takayasu Arteritis

Abstract Full Text
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JAMA Neurol. 2015;72(8):943-946. doi:10.1001/jamaneurol.2015.0840

This case report describes a woman in her 70s experiencing right-sided temporal pain and jaw claudication.

Fragile X Tremor Ataxia Syndrome With Rapidly Progressive Myopathy

Abstract Full Text
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JAMA Neurol. 2015;72(8):946-948. doi:10.1001/jamaneurol.2015.0812

This case report describes a man in his 60s who presented with a 10-month history of rapidly progressive motor impairment.

Comment & Response

Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2015;72(8):948-949. doi:10.1001/jamaneurol.2015.0899

Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2015;72(8):948. doi:10.1001/jamaneurol.2015.0902

Diabetes Mellitus and Cognitive Resilience

Abstract Full Text
JAMA Neurol. 2015;72(8):949. doi:10.1001/jamaneurol.2015.1316

Diabetes Mellitus and Cognitive Resilience—Reply

Abstract Full Text
JAMA Neurol. 2015;72(8):949-950. doi:10.1001/jamaneurol.2015.1319
Correction

Error in Byline

Abstract Full Text
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JAMA Neurol. 2015;72(8):950. doi:10.1001/jamaneurol.2015.1682

Error in Figure

Abstract Full Text
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JAMA Neurol. 2015;72(8):950. doi:10.1001/jamaneurol.2015.1752

Redundant Information in Text and Incorrect Reference

Abstract Full Text
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JAMA Neurol. 2015;72(8):950. doi:10.1001/jamaneurol.2015.1764
Book and Media Review

Review of Infections of the Central Nervous System

Abstract Full Text
JAMA Neurol. 2015;72(8):951. doi:10.1001/jamaneurol.2015.0967
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2015;72(8):850. doi:10.1001/jamaneurol.2014.2862
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