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October 2016, Vol 73, No. 10, Pages 1165-1260

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(10):1165. doi:10.1001/jamaneurol.2015.2485
Viewpoint

The Roadmap to Value-Based Care

Abstract Full Text
JAMA Neurol. 2016;73(10):1173-1174. doi:10.1001/jamaneurol.2016.1299

This Viewpoint discusses how the US health care system will transition from volume-based to value-based payment and care under the Medicare Access and Children’s Health Insurance Program Reauthorization Act of 2015.

Editorial

New Reasons to Pursue the Therapeutic Potential of Synthetic Nucleic Acids for Neurological Diseases

Abstract Full Text
JAMA Neurol. 2016;73(10):1175-1177. doi:10.1001/jamaneurol.2016.2571

Cause of Suspected Non–Alzheimer Disease Pathophysiology: If Not Tau Pathology, Then What?

Abstract Full Text
JAMA Neurol. 2016;73(10):1177-1179. doi:10.1001/jamaneurol.2016.2842

Brain Atrophy on Magnetic Resonance Imaging as a Biomarker of Neurodegeneration

Abstract Full Text
JAMA Neurol. 2016;73(10):1179-1182. doi:10.1001/jamaneurol.2016.2843

Status Epilepticus and Brain Atrophy: Shrinkage Is a Growing Problem

Abstract Full Text
JAMA Neurol. 2016;73(10):1182-1183. doi:10.1001/jamaneurol.2016.2639

Do ω-3 Fatty Acids Regulate Cerebral β Amyloid?

Abstract Full Text
JAMA Neurol. 2016;73(10):1183-1184. doi:10.1001/jamaneurol.2016.2534
Original Investigation

Heterogeneity in Suspected Non–Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals

Abstract Full Text
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JAMA Neurol. 2016;73(10):1185-1191. doi:10.1001/jamaneurol.2016.2237

This cohort study assesses PET-measured tau deposition and cognitive decline over 5 years in Harvard Aging Brain study participants who were beta-amyloid-negative with neurodegeneration at baseline.

Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology

Abstract Full Text
free access
JAMA Neurol. 2016;73(10):1192-1200. doi:10.1001/jamaneurol.2016.2642

This cohort study characterizes differences by stage in longitudinal β-amyloid deposition and hippocampal atrophy in cognitively normal patients with preclinical Alzheimer disease at baseline.

Progressive Brain Atrophy in Super-refractory Status Epilepticus

Abstract Full Text
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JAMA Neurol. 2016;73(10):1201-1207. doi:10.1001/jamaneurol.2016.1572

This case series describes changes in MRI measures of brain atrophy over time in patients with super-refractory status epilepticus who receive anesthetic agents for seizure control.

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis

Abstract Full Text
free access
JAMA Neurol. 2016;73(10):1208-1216. doi:10.1001/jamaneurol.2016.1924

This cross-sectional study investigates correlations between serum DHA levels and cerebral amyloidosis, brain volumes, and neuropsychological testing measures in Aging Brain Study participants.

Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2016;73(10):1217-1224. doi:10.1001/jamaneurol.2016.2245

This cohort study examines the association of GBA mutations and E326K polymorphisms with progression of motor symptoms and cognitive decline in patients with Parkinson disease.

Safety and Outcome of Intra-Arterial Treatment for Basilar Artery Occlusion

Abstract Full Text
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JAMA Neurol. 2016;73(10):1225-1230. doi:10.1001/jamaneurol.2016.1408

This case series reports clinical and functional outcomes and complications of intra-arterial treatment (thrombolysis or mechanical thrombectomy) in patients with basilar artery occlusion.

The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2016;73(10):1231-1237. doi:10.1001/jamaneurol.2016.2539

This cohort study investigates associations between coronary risk factors, stroke, and late-onset Alzheimer dementia in patients with familial disease.

Clinical Implications of Basic Neuroscience Research

Synthetic Nucleic Acids and Treatment of Neurological Diseases

Abstract Full Text
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JAMA Neurol. 2016;73(10):1238-1242. doi:10.1001/jamaneurol.2016.2089

This study reviews the use of ASOs for the treatment of neurological disorders.

Images in Neurology

Bilateral Infarction of the Corpus Callosum in a Patient With a Single Pericallosal Artery

Abstract Full Text
JAMA Neurol. 2016;73(10):1246-1247. doi:10.1001/jamaneurol.2016.1230

This case report describes the clinical and imaging features of a man in his 60s who had occlusion of a single pericallosal artery causing

bilateral corpus callosum infarction.

Characteristic Neuroimaging Abnormalities of Korsakoff Syndrome

Abstract Full Text
JAMA Neurol. 2016;73(10):1248-1249. doi:10.1001/jamaneurol.2016.1843

This case report describes the clinical and neuroimaging manifestations of Korsakoff syndrome.

JAMA Neurology Clinical Challenge

A Young Man With Recurrent Coma and Refractory Status Epilepticus

Abstract Full Text
JAMA Neurol. 2016;73(10):1243-1244. doi:10.1001/jamaneurol.2016.1788

A man in his 30s presented with a 5-day history of vomiting, followed by lethargy and confusion. Two years prior, he had been hospitalized with coma with no identifiable precipitant. What is your diagnosis?

Observation

Bortezomib Treatment for Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis

Abstract Full Text
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JAMA Neurol. 2016;73(10):1251-1253. doi:10.1001/jamaneurol.2016.2588

This case series describes 2 women with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis whose disease remitted with bortezomib treatment.

Comment & Response

Spectrum of Movement Disorders in Mitochondrial Disorders

Abstract Full Text
JAMA Neurol. 2016;73(10):1253-1254. doi:10.1001/jamaneurol.2016.2581

Spectrum of Movement Disorders in Mitochondrial Disorders–Reply

Abstract Full Text
JAMA Neurol. 2016;73(10):1254-1255. doi:10.1001/jamaneurol.2016.2578

Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain

Abstract Full Text
JAMA Neurol. 2016;73(10):1255. doi:10.1001/jamaneurol.2016.2796

Association of Alzheimer Disease Susceptibility Variants and Gene Expression in the Human Brain—Reply

Abstract Full Text
JAMA Neurol. 2016;73(10):1255. doi:10.1001/jamaneurol.2016.2799

The Dark Matter of Cerebral Microbleeds: Implications for Thrombolysis and Other Clinical Scenarios

Abstract Full Text
JAMA Neurol. 2016;73(10):1255-1256. doi:10.1001/jamaneurol.2016.2948

The Dark Matter of Cerebral Microbleeds—Reply

Abstract Full Text
JAMA Neurol. 2016;73(10):1256-1257. doi:10.1001/jamaneurol.2016.2937

Factors Associated With Neurological Outcome After Childhood Stroke—Reply

Abstract Full Text
JAMA Neurol. 2016;73(10):1257-1258. doi:10.1001/jamaneurol.2016.2934

Factors Associated With Neurological Outcome After Childhood Stroke

Abstract Full Text
JAMA Neurol. 2016;73(10):1257. doi:10.1001/jamaneurol.2016.2951

Comparing Painful Stimulation vs Rest in Studies of Pain

Abstract Full Text
JAMA Neurol. 2016;73(10):1258-1259. doi:10.1001/jamaneurol.2016.2989

Comparing Painful Stimulation vs Rest in Studies of Pain—Reply

Abstract Full Text
JAMA Neurol. 2016;73(10):1259-1260. doi:10.1001/jamaneurol.2016.2992
Correction

Omitted Author Affiliation

Abstract Full Text
free access
JAMA Neurol. 2016;73(10):1260. doi:10.1001/jamaneurol.2016.3119
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(10):1172. doi:10.1001/jamaneurol.2015.2486
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