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September 2021 - July 1959

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March 2016, Vol 73, No. 3, Pages 251-359

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):251. doi:10.1001/jamaneurol.2015.2443
Viewpoint

Next Generation Neurology

Antisense Oligonucleotides for Duchenne Muscular Dystrophy: Why No Neurologist Should Skip This

Abstract Full Text
JAMA Neurol. 2016;73(3):259-260. doi:10.1001/jamaneurol.2015.4011

This Viewpoint discusses the use of exon skipping therapies eteplirsen and drisapersen in Duchenne muscular dystrophy.

Next Generation Neurology

The Case for Neurological Network Diseases

Abstract Full Text
JAMA Neurol. 2016;73(3):261-262. doi:10.1001/jamaneurol.2015.3689

This Viewpoint provides examples of diseases to illustrate how the understanding of neurological disease has evolved from an elementary mendelian view.

Editorial

The Long Drive Ahead to Better Understanding Chronic Traumatic Encephalopathy: First (Case) and 10 (Years Later)

Abstract Full Text
JAMA Neurol. 2016;73(3):263-265. doi:10.1001/jamaneurol.2015.4297

Thirty Years After the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Trial: A New Era for Stroke Therapy

Abstract Full Text
JAMA Neurol. 2016;73(3):265-267. doi:10.1001/jamaneurol.2015.4453

Uncovering Neuroanatomical Networks Responsible for Abnormal Eating Behavior in Frontotemporal Dementia

Abstract Full Text
JAMA Neurol. 2016;73(3):267-268. doi:10.1001/jamaneurol.2015.4496

New and Appropriate Goals for Parkinson Disease Physical Therapy

Abstract Full Text
JAMA Neurol. 2016;73(3):269-270. doi:10.1001/jamaneurol.2015.4449

Implementing Recommendations for Depression Screening of Adults: How Can Neurology Contribute to the Dialogue?

Abstract Full Text
JAMA Neurol. 2016;73(3):270-271. doi:10.1001/jamaneurol.2015.5048
Original Investigation

Stent Retrievers for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):275-281. doi:10.1001/jamaneurol.2015.4441

This meta-analysis of randomized clinical trials aims to quantify the benefits and risks of using stent retrievers in addition to recombinant tissue plasminogen activator for the treatment of acute ischemic stroke.

Assessment of Eating Behavior Disturbance and Associated Neural Networks in Frontotemporal Dementia

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):282-290. doi:10.1001/jamaneurol.2015.4478

This study defines the severity of abnormal eating behavior and sucrose preference and associated neural networks in patients with behavioral variant frontotemporal dementia and semantic dementia.

Physiotherapy and Occupational Therapy vs No Therapy in Mild to Moderate Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):291-299. doi:10.1001/jamaneurol.2015.4452

This randomized clinical trial aims to evaluate the clinical effectiveness of individualized physiotherapy and occupational therapy in Parkinson disease.

Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children

Abstract Full Text
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JAMA Neurol. 2016;73(3):300-307. doi:10.1001/jamaneurol.2015.4388

This prospective study of 61 children with enterovirus-related neurological disease during a 2013 outbreak in Sydney, Australia, further characterizes enterovirus 71 disease and outcomes in children.

Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial

Abstract Full Text
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JAMA Neurol. 2016;73(3):308-315. doi:10.1001/jamaneurol.2015.4315

This post hoc analysis of a randomized clinical trial aims to determine baseline features that were associated with a high rate of the primary end point in the medical arm of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Transient Neurological Symptoms in Patients With Intracerebral Hemorrhage

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):316-320. doi:10.1001/jamaneurol.2015.4202

This case series describes the clinical presentation, neuroimaging findings, and outcomes of 17 patients with intracerebral hemorrhage and transient neurological signs and symptoms.

Association Between Change in Body Mass Index, Unified Parkinson’s Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):321-328. doi:10.1001/jamaneurol.2015.4265

This secondary analysis of the NET-PD LS-1 reports on the association between change in body mass index, Unified Parkinson’s Disease Rating Scale scores, and survival among persons with Parkinson disease.

Participation in Physical Activity and Risk for Amyotrophic Lateral Sclerosis Mortality Among Postmenopausal Women

Abstract Full Text
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JAMA Neurol. 2016;73(3):329-336. doi:10.1001/jamaneurol.2015.4487

This cohort study uses data from the Women’s Health Initiative to evaluate whether physical activity is associated with risk of death from amyotrophic lateral sclerosis among postmenopausal women.

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis: Results of Phase 1/2 and 2a Clinical Trials

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):337-344. doi:10.1001/jamaneurol.2015.4321

These 2 open-label proof-of-concept studies aim to determine the safety and possible clinical efficacy of autologous mesenchymal stem cell–neurotrophic growth factor cell transplantation in patients with amyotrophic lateral sclerosis.

Images in Neurology

Altered Brain Computed Tomography Perfusion in Patients With Fluctuating Lacunar Syndrome and Normal Magnetic Resonance Imaging

Abstract Full Text
JAMA Neurol. 2016;73(3):348-349. doi:10.1001/jamaneurol.2015.4026

This article describes 2 cases where computed tomography perfusion showed acute ischemic lesions not visible on diffusion-weighted imaging.

Cortical Cystic Necrosis in Wilson Disease

Abstract Full Text
JAMA Neurol. 2016;73(3):350-351. doi:10.1001/jamaneurol.2015.3595

This case report discusses a patient with Wilson disease with unusual extensive cortical cystic lesions and partial poor response to decupuration and seizures.

JAMA Neurology Clinical Challenge

Leptomeningeal Enhancement in a Patient With Progressive Cranial Neuropathies and Lumbosacral Radiculopathies

Abstract Full Text
JAMA Neurol. 2016;73(3):345-346. doi:10.1001/jamaneurol.2015.3965

A 69-year-old white man presented to the emergency department reporting 2 months of progressive bilateral lower extremity weakness, left facial weakness, and diplopia in the setting of a 20.4-kg weight loss over the previous 6 months and new onset urinary incontinence. What is your diagnosis?

Observation

Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player

Abstract Full Text
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JAMA Neurol. 2016;73(3):353-355. doi:10.1001/jamaneurol.2015.3998

This case report describes a 25-year-old former college football player who had more than 10 concussions while playing football and postmortem pathologically confirmed chronic traumatic encephalopathy.

Primary Cutaneous Cryptococcus in a Patient With Multiple Sclerosis Treated With Fingolimod

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):355-356. doi:10.1001/jamaneurol.2015.4259

A 62-year-old woman with multiple sclerosis treated with fingolimod for 3 years presented to clinic with a tender nodule on the forehead that was diagnosed by a tissue culture as Cryptococcus neoformans. The patient was diagnosed with primary cutaneous cryptococcosis.

Comment & Response

25-Hydroxyvitamin D in Patients With Cognitive Decline

Abstract Full Text
JAMA Neurol. 2016;73(3):356-357. doi:10.1001/jamaneurol.2015.4182

25-Hydroxyvitamin D in Patients With Cognitive Decline

Abstract Full Text
JAMA Neurol. 2016;73(3):357. doi:10.1001/jamaneurol.2015.4188

25-Hydroxyvitamin D in Patients With Cognitive Decline—Reply

Abstract Full Text
JAMA Neurol. 2016;73(3):358. doi:10.1001/jamaneurol.2015.4185
Correction

Error in Figure Labeling

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):358. doi:10.1001/jamaneurol.2016.0406
Book and Media Review

Review of Manual of Botulinum Toxin Therapy, 2nd ed

Abstract Full Text
JAMA Neurol. 2016;73(3):359. doi:10.1001/jamaneurol.2015.3462
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(3):258. doi:10.1001/jamaneurol.2015.2444
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