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June 2019 - July 1959

Decade

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Issue

August 2016, Vol 73, No. 8, Pages 901-1036

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):901. doi:10.1001/jamaneurol.2015.2473
Viewpoint

Anticipating the Challenges of Zika Virus and the Incidence of Guillain-Barré Syndrome

Abstract Full Text
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JAMA Neurol. 2016;73(8):905-906. doi:10.1001/jamaneurol.2016.1268

This Viewpoint discusses challenges that the US health care system could face if the incidence of Guillain-Barré syndrome were to increase with the arrival of Zika.

Editorial

Neurologic Immune-Related Adverse Events in Oncology Care

Abstract Full Text
JAMA Neurol. 2016;73(8):907-908. doi:10.1001/jamaneurol.2016.1564

Cerebral Microbleeds, Cognition, and Therapeutic Implications

Abstract Full Text
JAMA Neurol. 2016;73(8):908-910. doi:10.1001/jamaneurol.2016.1388

Cortical Volume Loss and Neurologic Dysfunction in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(8):910-912. doi:10.1001/jamaneurol.2016.1535

Is Season of Birth Important for Multiple Sclerosis Risk?

Abstract Full Text
JAMA Neurol. 2016;73(8):912-913. doi:10.1001/jamaneurol.2016.1763

Recognizing and Preventing Intracerebral Hematoma Expansion

Abstract Full Text
JAMA Neurol. 2016;73(8):914-915. doi:10.1001/jamaneurol.2016.1899

Dementia After Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2016;73(8):916-917. doi:10.1001/jamaneurol.2016.1538

Coenzyme Q10 as a Peripheral Biomarker for Multiple System Atrophy

Abstract Full Text
JAMA Neurol. 2016;73(8):917-919. doi:10.1001/jamaneurol.2016.1810

Are We Ready for a Potential Increase in Parkinson Incidence?

Abstract Full Text
JAMA Neurol. 2016;73(8):919-921. doi:10.1001/jamaneurol.2016.1599

The Consideration of Flow Diversion in Modern Cerebrovascular Neurosurgery

Abstract Full Text
JAMA Neurol. 2016;73(8):921-922. doi:10.1001/jamaneurol.2016.0937

Disentangling (Epi)Genetic and Environmental Contributions to the Mitochondrial 3243A>G Mutation Phenotype: Phenotypic Destiny in Mitochondrial Disease?

Abstract Full Text
JAMA Neurol. 2016;73(8):923-925. doi:10.1001/jamaneurol.2016.1676

Syphilis Screening in Neurology

Abstract Full Text
JAMA Neurol. 2016;73(8):926-927. doi:10.1001/jamaneurol.2016.1955

This Editorial discusses the US Preventive Services Task Force recommendation statement on screening for syphilis infection in nonpregnant adults and adolescents.

Original Investigation

Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer

Abstract Full Text
free access has active quiz
JAMA Neurol. 2016;73(8):928-933. doi:10.1001/jamaneurol.2016.1399

This case report describes the induction of autoimmune encephalitis in 2 patients after treatment of metastatic cancer with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab.

Association of Cerebral Microbleeds With Cognitive Decline and Dementia

Abstract Full Text
free access has active quiz
JAMA Neurol. 2016;73(8):934-943. doi:10.1001/jamaneurol.2016.1017

This population-based study assesses whether microbleeds are associated with an increased risk for cognitive impairment and dementia in the general population.

Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):944-953. doi:10.1001/jamaneurol.2016.0966

This cross-sectional study uses trial data to investigate correlations between MR-measured localized gray matter atrophy and specific clinical deficits in patients with relapsing-remitting multiple sclerosis.

Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):954-960. doi:10.1001/jamaneurol.2016.1463

This study examines data on the season and region of birth in individuals in the United Kingdom who develop multiple sclerosis.

Association Between Hypodensities Detected by Computed Tomography and Hematoma Expansion in Patients With Intracerebral Hemorrhage

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):961-968. doi:10.1001/jamaneurol.2016.1218

This study investigates whether hypodensities detected by computed tomography are associated with hematoma expansion in patients with intracerebral hemorrhage.

Risk Factors Associated With Early vs Delayed Dementia After Intracerebral Hemorrhage

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):969-976. doi:10.1001/jamaneurol.2016.0955

This cohort study investigates clinical and imaging variables associated with early and delayed dementia after intracerebral hemorrhage.

Plasma Coenzyme Q10 Levels in Patients With Multiple System Atrophy

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):977-980. doi:10.1001/jamaneurol.2016.1325

This case-control study compares the levels of plasma coenzyme Q10 in patients with multiple system atrophy with those in age-, sex-, and COQ2 genotype–matched controls.

Time Trends in the Incidence of Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):981-989. doi:10.1001/jamaneurol.2016.0947

This study investigates secular trends (period effects) and birth cohort trends in the incidence of parkinsonism and Parkinson disease over 30 years .

Clinical Phenotype and Segregation of Mitochondrial 3243A>G Mutation in 2 Pairs of Monozygotic Twins

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):990-993. doi:10.1001/jamaneurol.2016.0886

This case series describes 2 pairs of monozygotic twins with mitochondrial 3243A>G mutation who developed mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome.

Total Magnetic Resonance Imaging Burden of Small Vessel Disease in Cerebral Amyloid Angiopathy: An Imaging-Pathologic Study of Concept Validation

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):994-1001. doi:10.1001/jamaneurol.2016.0832

This cross-sectional study investigates whether a composite score can be developed to capture the total brain magnetic resonance imaging burden of small vessel disease in cerebral amyloid angiopathy.

Review

Flow Diversion for the Treatment of Intracranial Aneurysms

Abstract Full Text
JAMA Neurol. 2016;73(8):1002-1008. doi:10.1001/jamaneurol.2016.0609

This narrative review summarizes current flow diversion stent technologies for managing large or wide-necked cerebral aneurysms not amenable to standard procedures, and evidence supporting their use.

Clinical Implications of Basic Neuroscience Research

Molecular Pathogenic Basis for GABRG2 Mutations Associated With a Spectrum of Epilepsy Syndromes, From Generalized Absence Epilepsy to Dravet Syndrome

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):1009-1016. doi:10.1001/jamaneurol.2016.0449

This review article discusses the molecular pathogenic basis for idiopathic generalized epilepsies associated with mutations in the inhibitory GABAA receptor γ2 subunit gene, GABRG2, an established epilepsy gene.

Images in Neurology

Characteristic Pulvinar Sign in Pseudo-α-galactosidase Deficiency Syndrome

Abstract Full Text
JAMA Neurol. 2016;73(8):1020-1021. doi:10.1001/jamaneurol.2016.0268

This case report describes a woman in her 40s who developed pulvinar hyperintensity through pseudo-α-galactosidase deficiency syndrome.

JAMA Neurology Clinical Challenge

Worsening Stroke Symptoms in an 80-Year-Old Man

Abstract Full Text
JAMA Neurol. 2016;73(8):1017-1018. doi:10.1001/jamaneurol.2016.0421

An 80-year-old man presented to the hospital with new-onset slurred speech and left-sided facial droop. Magnetic resonance imaging scans of the head were visually interpreted to show an acute infarct involving the posterior right frontal lobe. What is your diagnosis?

Observation

Enteroviral Postencephalitic Parkinsonism With Evidence of Impaired Presynaptic Dopaminergic Function

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):1023-1025. doi:10.1001/jamaneurol.2016.1043

This case report describes a woman with enteroviral postencephalitic parkinsonism with impaired presynaptic dopaminergic function.

Comment & Response

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1025. doi:10.1001/jamaneurol.2016.1488

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1025-1026. doi:10.1001/jamaneurol.2016.1491

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1497

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1500

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1026-1027. doi:10.1001/jamaneurol.2016.1503

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1027. doi:10.1001/jamaneurol.2016.1959

Proton Pump Inhibitors and Dementia Incidence

Abstract Full Text
JAMA Neurol. 2016;73(8):1027-1028. doi:10.1001/jamaneurol.2016.1962

Proton Pump Inhibitors and Dementia Incidence—Reply

Abstract Full Text
JAMA Neurol. 2016;73(8):1028-1029. doi:10.1001/jamaneurol.2016.1494

Nitric Oxide Deficiency Triggering Strokelike Episodes

Abstract Full Text
JAMA Neurol. 2016;73(8):1029-1030. doi:10.1001/jamaneurol.2016.1646

Nitric Oxide Deficiency Triggering Strokelike Episodes—Reply

Abstract Full Text
JAMA Neurol. 2016;73(8):1030. doi:10.1001/jamaneurol.2016.1649

Instrument for Predicting Early Stroke Recurrence: Ambiguity and Biases

Abstract Full Text
JAMA Neurol. 2016;73(8):1030-1031. doi:10.1001/jamaneurol.2016.1724

Instrument for Predicting Early Stroke Recurrence: Ambiguity and Biases—Reply

Abstract Full Text
JAMA Neurol. 2016;73(8):1031-1032. doi:10.1001/jamaneurol.2016.1727

Computed Tomography Perfusion and Diffusion-Weighted Imaging in Patients With Acute Stroke

Abstract Full Text
JAMA Neurol. 2016;73(8):1032. doi:10.1001/jamaneurol.2016.1680

Computed Tomography Perfusion and Diffusion-Weighted Imaging in Patients With Acute Stroke—Reply

Abstract Full Text
JAMA Neurol. 2016;73(8):1032-1033. doi:10.1001/jamaneurol.2016.1683

Chronic Traumatic Encephalopathy in a 25-Year-Old Athlete—Distribution of Lesions

Abstract Full Text
JAMA Neurol. 2016;73(8):1033. doi:10.1001/jamaneurol.2016.1396
Correction

Wording Error in Conclusions Section

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):1033. doi:10.1001/jamaneurol.2016.3034
Book and Media Review

Review of Medication-Induced Movement Disorders

Abstract Full Text
JAMA Neurol. 2016;73(8):1034. doi:10.1001/jamaneurol.2016.1760
Obituary

In Memoriam: Noshir H. Wadia, MD, FRCP(London), FNA, FASc, FAMS, DSc(Hons) (1925-2016)

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):1035-1036. doi:10.1001/jamaneurol.2016.1860
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(8):904. doi:10.1001/jamaneurol.2015.2474
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