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September 2021 - July 1959

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September 2016, Vol 73, No. 9, Pages 1043-1161

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(9):1043. doi:10.1001/jamaneurol.2015.2479
Editorial

Tau and β-Amyloid—The Malignant Duo

Abstract Full Text
JAMA Neurol. 2016;73(9):1049-1050. doi:10.1001/jamaneurol.2016.2481

Behavioral Variant Frontotemporal Dementia: One Syndrome, Several Circuits, Many Mechanisms

Abstract Full Text
JAMA Neurol. 2016;73(9):1051-1052. doi:10.1001/jamaneurol.2016.1793

Perspectives on Safety and Efficacy—The BOLD Phase 2 Extension Study of Siponimod in Relapsing-Remitting Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(9):1052-1054. doi:10.1001/jamaneurol.2016.2284

Seronegative Myasthenia Gravis—A Vanishing Disorder?

Abstract Full Text
JAMA Neurol. 2016;73(9):1055-1056. doi:10.1001/jamaneurol.2016.2277

The Puzzle of Huntington Disease Phenocopies

Abstract Full Text
JAMA Neurol. 2016;73(9):1056-1058. doi:10.1001/jamaneurol.2016.2095

Contactin-Associated Protein-like 2 Antibodies: Tackling the Issue of Syndrome Diversity

Abstract Full Text
JAMA Neurol. 2016;73(9):1058-1059. doi:10.1001/jamaneurol.2016.1739

Are Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease “Separate but Equal”?

Abstract Full Text
JAMA Neurol. 2016;73(9):1060-1061. doi:10.1001/jamaneurol.2016.1633
Original Investigation

Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings

Abstract Full Text
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JAMA Neurol. 2016;73(9):1062-1069. doi:10.1001/jamaneurol.2016.1948

This study uses pooled data from 3 prospective cohort studies to assesse whether traumatic brain injury with loss of consciousness is associated with an increased risk for clinical and neuropathologic findings of Alzheimer disease, Parkinson disease, and other dementias among US adults.

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

Abstract Full Text
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JAMA Neurol. 2016;73(9):1070-1077. doi:10.1001/jamaneurol.2016.2078

This study examines the use of [18F]-AV-1451 positron emission tomography imaging in individuals with Alzheimer disease (AD) compared with cognitively normal status in staging AD and determining interactions between β-amyloid and tauopathy.

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration

Abstract Full Text
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JAMA Neurol. 2016;73(9):1078-1088. doi:10.1001/jamaneurol.2016.2016

This case series uses structural MRI to characterize the subtype differences in functional networks of patients with behavioral variant frontotemporal dementia.

Safety and Efficacy of Siponimod (BAF312) in Patients With Relapsing-Remitting Multiple Sclerosis: Dose-Blinded, Randomized Extension of the Phase 2 BOLD Study

Abstract Full Text
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JAMA Neurol. 2016;73(9):1089-1098. doi:10.1001/jamaneurol.2016.1451

This dose-blinded extension phase of the BOLD Study assesses the safety and efficacy of siponimod for up to 24 months in patients with relapsing-remitting multiple sclerosis.

Clinical Characteristics of Patients With Double-Seronegative Myasthenia Gravis and Antibodies to Cortactin

Abstract Full Text
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JAMA Neurol. 2016;73(9):1099-1104. doi:10.1001/jamaneurol.2016.2032

This cross-sectional study examines the clinical features of patients with double-seronegative myasthenia gravis who have cortactin antibodies.

Expanding the Spectrum of Genes Involved in Huntington Disease Using a Combined Clinical and Genetic Approach

Abstract Full Text
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JAMA Neurol. 2016;73(9):1105-1114. doi:10.1001/jamaneurol.2016.2215

This case series examines patients with Huntington disease (HD) phenotypes to determine the frequency of HD phenocopies with typical features of HD but without pathological CAG repeat expansions in HTT in an attempt to improve the positive diagnosis rate.

Characterization of a Subtype of Autoimmune Encephalitis With Anti–Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures

Abstract Full Text
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JAMA Neurol. 2016;73(9):1115-1124. doi:10.1001/jamaneurol.2016.1585

This case series describes the clinical and radiographic characteristics of patients with anti–contactin-associated protein-like 2 (CASPR2) antibodies in their cerebrospinal fluid.

Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study

Abstract Full Text
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JAMA Neurol. 2016;73(9):1125-1132. doi:10.1001/jamaneurol.2016.1236

This case-control study uses a family with late-onset autosomal dominant Alzheimer disease caused by a presenilin 1 (PSEN1) gene mutation to mitigate the potential confound of age when comparing autosomal dominant Alzheimer disease and late-onset Alzheimer disease.

Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients

Abstract Full Text
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JAMA Neurol. 2016;73(9):1133-1140. doi:10.1001/jamaneurol.2016.2067

This case-control study compares the long-term outcome after allogeneic hematopoietic stem cell transplantation compared with nontransplanted patients among a cohort with juvenile metachromatic leukodystrophy.

Review

Recruiting Patients With Stroke Into Cell Therapy Trials: A Review

Abstract Full Text
JAMA Neurol. 2016;73(9):1141-1144. doi:10.1001/jamaneurol.2016.0940

This review examines ethical issues surrounding the recruitment of patients with stroke into cell therapy studies.

Clinical Pathologic Conference

A Rare Cause of Myoclonus: A Cupric Conundrum

Abstract Full Text
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JAMA Neurol. 2016;73(9):1145-1148. doi:10.1001/jamaneurol.2016.1553

This case report describes a 22-year-old woman with action myoclonus renal failure syndrome.

Images in Neurology

Rapidly Cycling Auras and Episodic Focal Dystonia in Anti-LGI1 Autoimmune Encephalitis

Abstract Full Text
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JAMA Neurol. 2016;73(9):1150. doi:10.1001/jamaneurol.2016.1085

This case report describes a 57-year-old man with hemochromatosis and panhypopituitarism who presented with a 6-month history of word-finding difficulty, short-term memory loss, and rapidly cycling symptoms.

Research Letter

Racial Differences in Utilization of Life-Sustaining vs Curative Inpatient Procedures After Stroke

Abstract Full Text
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JAMA Neurol. 2016;73(9):1151-1153. doi:10.1001/jamaneurol.2016.1914

This study compares racial differences in the use of 6 common nondiagnostic inpatient procedures after stroke.

Comment & Response

Use of Diffusion-Weighted Magnetic Resonance Imaging in Sporadic Creutzfeldt-Jakob Disease

Abstract Full Text
JAMA Neurol. 2016;73(9):1153-1154. doi:10.1001/jamaneurol.2016.2381

Stent Retrievers for Treating Anterior Circulation Acute Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2016;73(9):1154-1155. doi:10.1001/jamaneurol.2016.2201

Use of Diffusion-Weighted Magnetic Resonance Imaging in Sporadic Creutzfeldt-Jakob Disease—Reply

Abstract Full Text
JAMA Neurol. 2016;73(9):1154. doi:10.1001/jamaneurol.2016.2384

Stent Retrievers for Treating Anterior Circulation Acute Ischemic Stroke—Reply

Abstract Full Text
JAMA Neurol. 2016;73(9):1155-1156. doi:10.1001/jamaneurol.2016.2204

The Danger of Not Treating Parkinson Disease Psychosis—Reply

Abstract Full Text
JAMA Neurol. 2016;73(9):1156-1157. doi:10.1001/jamaneurol.2016.2274

The Danger of Not Treating Parkinson Disease Psychosis

Abstract Full Text
JAMA Neurol. 2016;73(9):1156. doi:10.1001/jamaneurol.2016.2280

Surgical Treatment of Temporal Lobe Epilepsy: Type and Extent of Surgery Matters

Abstract Full Text
JAMA Neurol. 2016;73(9):1157. doi:10.1001/jamaneurol.2016.1847

Surgical Treatment of Temporal Lobe Epilepsy—Reply: Type and Extent of Surgery Matters

Abstract Full Text
JAMA Neurol. 2016;73(9):1157-1158. doi:10.1001/jamaneurol.2016.1850

Association Between Rosacea and Parkinson Disease

Abstract Full Text
JAMA Neurol. 2016;73(9):1158-1159. doi:10.1001/jamaneurol.2016.1875

Association Between Rosacea and Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2016;73(9):1159-1160. doi:10.1001/jamaneurol.2016.1864

Association Between Rosacea and Parkinson Disease

Abstract Full Text
JAMA Neurol. 2016;73(9):1159. doi:10.1001/jamaneurol.2016.2321
Correction

Error in Table and Figure

Abstract Full Text
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JAMA Neurol. 2016;73(9):1160. doi:10.1001/jamaneurol.2016.2806

Incorrect Degree for Author

Abstract Full Text
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JAMA Neurol. 2016;73(9):1160. doi:10.1001/jamaneurol.2016.3415
Book and Media Review

Review of Walsh and Hoyt’s Clinical Neuro-Ophthalmology

Abstract Full Text
JAMA Neurol. 2016;73(9):1161. doi:10.1001/jamaneurol.2016.2524
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(9):1048. doi:10.1001/jamaneurol.2015.2480
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