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July 2019 - July 1959

Decade

Year

Issue

December 2017, Vol 74, No. 12, Pages 1389-1508

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(12):1389. doi:10.1001/jamaneurol.2016.4029
Editorial

A Novel Clinical Score to Assess Seizure Risk

Abstract Full Text
JAMA Neurol. 2017;74(12):1395-1396. doi:10.1001/jamaneurol.2017.1922

Increasing Evidence for an Association Between Amyotrophic Lateral Sclerosis and Psychiatric Disorders

Abstract Full Text
JAMA Neurol. 2017;74(12):1396-1398. doi:10.1001/jamaneurol.2017.1920

Impaired Cognition and the Risk of Parkinson Disease: Trouble in Mind

Abstract Full Text
JAMA Neurol. 2017;74(12):1398-1400. doi:10.1001/jamaneurol.2017.1474

The Complexity of Subjective Cognitive Decline

Abstract Full Text
JAMA Neurol. 2017;74(12):1400-1402. doi:10.1001/jamaneurol.2017.2224

Death by Gun Violence—A Public Health Crisis

Abstract Full Text
free access
JAMA Neurol. 2017;74(12):1402-1403. doi:10.1001/jamaneurol.2017.3533
Original Investigation

Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz has audio
JAMA Neurol. 2017;74(12):1412-1418. doi:10.1001/jamaneurol.2017.3098

This randomized clinical trial compares focused ultrasound thalamotomy with sham treatment for relieving tremor in patients with medication-refractory, tremor-dominant Parkinson disease.

Association of an Electroencephalography-Based Risk Score With Seizure Probability in Hospitalized Patients

Abstract Full Text
free access has active quiz
JAMA Neurol. 2017;74(12):1419-1424. doi:10.1001/jamaneurol.2017.2459

This study use seizure risk factors from electroencephalography and clinical history to create a simple scoring system for predicting the probability of seizures in patients with acute illness.

Clustering of Neuropsychiatric Disease in First-Degree and Second-Degree Relatives of Patients With Amyotrophic Lateral Sclerosis

Abstract Full Text
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JAMA Neurol. 2017;74(12):1425-1430. doi:10.1001/jamaneurol.2017.2699

This population-based, case-control, family aggregation study examines the frequency and range of neuropsychiatric conditions that occur within individual first-degree and second-degree relatives of patients with amyotrophic lateral sclerosis.

Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study

Abstract Full Text
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JAMA Neurol. 2017;74(12):1431-1438. doi:10.1001/jamaneurol.2017.2248

This population-based cohort study from the Rotterdam Study evaluates the association between cognitive function and risk of parkinsonism or Parkinson disease in participants who were free of parkinsonism and dementia.

Disability Trajectories Before and After Stroke and Myocardial Infarction: The Cardiovascular Health Study

Abstract Full Text
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JAMA Neurol. 2017;74(12):1439-1445. doi:10.1001/jamaneurol.2017.2802

This population-based cohort study evaluates the long-term effects of stroke on functional ability in patients before and after stroke compared with before and after myocardial infarction.

Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression

Abstract Full Text
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JAMA Neurol. 2017;74(12):1446-1454. doi:10.1001/jamaneurol.2017.2255

This longitudinal cohort study assesses peripheral inflammatory markers, tracks immune changes, and correlates these changes with disease progression in patients with amyotrophic lateral sclerosis.

Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden

Abstract Full Text
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JAMA Neurol. 2017;74(12):1455-1463. doi:10.1001/jamaneurol.2017.2216

This imaging substudy of the Harvard Aging Brain Study examined associations between subjective cognitive decline and global β-amyloid and tau burdens in regions of interest in clinically healthy older adults.

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines

Abstract Full Text
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JAMA Neurol. 2017;74(12):1464-1472. doi:10.1001/jamaneurol.2017.2822

This time course study using 1035 mice seeks to define consistent measures of disease in a transgenic mouse model that could be implemented by drug discovery programs for in vivo compound evaluation.

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

Abstract Full Text
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JAMA Neurol. 2017;74(12):1473-1480. doi:10.1001/jamaneurol.2017.2807

This cohort study uses data from the Religious Orders Study and the Rush Memory and Aging Project to investigate the association between brain gene expression, DNA methylation, and alteration of magnetic resonance imaging transverse relaxation in late-life cognitive decline.

Interpreting Biomarker Results in Individual Patients With Mild Cognitive Impairment in the Alzheimer’s Biomarkers in Daily Practice (ABIDE) Project

Abstract Full Text
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JAMA Neurol. 2017;74(12):1481-1491. doi:10.1001/jamaneurol.2017.2712

This cohort modelling study constructs biomarker-based prognostic models that enable determination of future Alzheimer disease dementia in patients with mild cognitive impairment.

Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment

Abstract Full Text
open access
JAMA Neurol. 2017;74(12):1492-1501. doi:10.1001/jamaneurol.2017.2814

This cohort study compared the performance of amyloid positron emission tomography and 5 β-amyloid cerebrospinal fluid assays for detecting amyloid deposition in the brains of patients with mild cognitive complaints.

Research Letter

Xp22.2 Chromosomal Duplication in Familial Intracranial Arachnoid Cyst

Abstract Full Text
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JAMA Neurol. 2017;74(12):1503-1504. doi:10.1001/jamaneurol.2017.3399

This study presents a genetic locus for intracranial arachnoid cysts.

Observation

Alternating Horner Syndrome With Vegetative Alterna and Spastic Quadraparesis After Bacterial Meningitis

Abstract Full Text
JAMA Neurol. 2017;74(12):1504-1506. doi:10.1001/jamaneurol.2017.2865

A 30-year-old woman with a remote history of Hemophilus influenzae type b meningitis causing quadraparesis was admitted to the hospital with Candida fungemia.

Comment & Response

Observations on a 2-Step Approach to Screening for Parkinson Disease

Abstract Full Text
JAMA Neurol. 2017;74(12):1506. doi:10.1001/jamaneurol.2017.3202

Observations on a 2-Step Approach to Screening for Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2017;74(12):1506-1507. doi:10.1001/jamaneurol.2017.3208

ADS-5102 (Amantadine) Extended Release for Levodopa-Induced Dyskinesia

Abstract Full Text
JAMA Neurol. 2017;74(12):1507-1508. doi:10.1001/jamaneurol.2017.3205

ADS 5102 (Amantadine) Extended Release for Levodopa-Induced Dyskinesia—Reply

Abstract Full Text
JAMA Neurol. 2017;74(12):1508. doi:10.1001/jamaneurol.2017.3211
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2017;74(12):1392. doi:10.1001/jamaneurol.2016.4030
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