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June 2019 - July 1959

Decade

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Issue

August 2017, Vol 74, No. 8, Pages 883-1015

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):883. doi:10.1001/jamaneurol.2016.4009
Viewpoint

Pediatric Migraine Prevention—First, Do No Harm

Abstract Full Text
JAMA Neurol. 2017;74(8):893-894. doi:10.1001/jamaneurol.2017.1011

This Viewpoint discusses the implications of the Childhood and Adolescent Migraine Prevention Study, which examined migraine preventive treatment options for children and adolescents.

Integration of Advanced Practice Clinicians in Neurology Practices

Abstract Full Text
JAMA Neurol. 2017;74(8):894-895. doi:10.1001/jamaneurol.2017.1382

This Viewpoint argues that incorporating advanced practice clinicians into more supported and empowered roles within neurology practices will improve patient care.

On the Brain

Winning the Fight to End Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2017;74(8):896-897. doi:10.1001/jamaneurol.2017.1279
Editorial

Reassuring News About Football and Cognitive Decline?Not So Fast

Abstract Full Text
JAMA Neurol. 2017;74(8):898-899. doi:10.1001/jamaneurol.2017.1324

Potential Influence of FDA-Sponsored Studies of Antiepilepsy Drugs on Generic and Brand-name Formulation Prescribing

Abstract Full Text
JAMA Neurol. 2017;74(8):900-901. doi:10.1001/jamaneurol.2017.0492

Dopaminergic Imaging and Prodromal Parkinson Disease: A Key Biomarker Arrives

Abstract Full Text
JAMA Neurol. 2017;74(8):901-903. doi:10.1001/jamaneurol.2017.0846

Extended-Release Amantadine—A Smart Pill for Treatment of Levodopa-Induced Dyskinesia but Does the Evidence Justify the Cost?

Abstract Full Text
JAMA Neurol. 2017;74(8):904-905. doi:10.1001/jamaneurol.2017.0954

Can the Spot Sign Identify Who Benefits From Aggressive Blood Pressure Reduction in Intracerebral Hemorrhage?

Abstract Full Text
JAMA Neurol. 2017;74(8):905-907. doi:10.1001/jamaneurol.2017.1022

Induction of New Autoimmune Diseases After Alemtuzumab Therapy for Multiple Sclerosis: Learning From Adversity

Abstract Full Text
JAMA Neurol. 2017;74(8):907-908. doi:10.1001/jamaneurol.2017.0325
Original Investigation

Association of Playing High School Football With Cognition and Mental Health Later in Life

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):909-918. doi:10.1001/jamaneurol.2017.1317

This cohort study uses data from the Wisconsin Longitudinal Study to estimate the association of playing high school football in the 1950s with cognitive impairment and depression at 65 years of age.

Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):919-926. doi:10.1001/jamaneurol.2017.0497

This randomized clinical trial examines whether a branded and a generic antiepileptic drug are biologically equivalent when administered to adults with epilepsy who are taking concomitant antiepileptic drugs.

Association Between Cirrhosis and Stroke in a Nationally Representative Cohort

Abstract Full Text
free access has active quiz has audio
JAMA Neurol. 2017;74(8):927-932. doi:10.1001/jamaneurol.2017.0923

This cohort study of Medicare claims data investigates the association between cirrhosis and various stroke types.

Conversion to Parkinson Disease in the PARS Hyposmic and Dopamine Transporter–Deficit Prodromal Cohort

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):933-940. doi:10.1001/jamaneurol.2017.0985

This longitudinal observational study determines if the combination of smell identification testing followed by dopamine transporter imaging can accurately and efficiently identify individuals from the general population at risk for conversion to a clinical diagnosis of Parkinson disease.

Clinical Trial

ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson Disease (EASE LID Study): A Randomized Clinical Trial

Abstract Full Text
open access has active quiz
JAMA Neurol. 2017;74(8):941-949. doi:10.1001/jamaneurol.2017.0943

This randomized, double-blind, placebo-controlled clinical trial evaluates the efficacy and safety of extended-release ADS-5102 (amantadine) 274-mg capsules for treatment of levodopa-induced dyskinesia in patients with Parkinson disease.

Intensive Blood Pressure Reduction and Spot Sign in Intracerebral Hemorrhage: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):950-960. doi:10.1001/jamaneurol.2017.1014

This secondary analysis of a randomized clinical trial investigates whether the spot sign is associated with intracerebral hemorrhage expansion and whether intensive blood pressure reduction reduces hematoma expansion and improves outcomes.

Interpreting Lymphocyte Reconstitution Data From the Pivotal Phase 3 Trials of Alemtuzumab

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):961-969. doi:10.1001/jamaneurol.2017.0676

This analysis of unpublished data from pivotal phase 3 trials of alemtuzumab in the treatment of multiple sclerosis investigates the association of efficacy with long-term depletion of memory T and B cells and hyperrepopulation of immature B cells.

Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):970-976. doi:10.1001/jamaneurol.2017.1125

This study examines the association of time of onset of autonomic dysfunction with disease progression and survival in Parkinson disease.

Safety of Converting From Tetrabenazine to Deutetrabenazine for the Treatment of Chorea

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):977-982. doi:10.1001/jamaneurol.2017.1352

This open-label, single-arm study evaluates the safety and explores the efficacy of conversion from tetrabenazine to deutetrabenazine in patients with chorea associated with Huntington disease.

Association Between Pregnancy and Perinatal Outcomes Among Women With Epilepsy

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):983-991. doi:10.1001/jamaneurol.2017.1310

This population-based cohort study examines the outcomes of epilepsy and use of antiepileptic drugs during pregnancy in women and infants.

Skeletal Muscle Involvement in Antisynthetase Syndrome

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):992-999. doi:10.1001/jamaneurol.2017.0934

This cohort study aims to elucidate the clinical features of myositis in patients with antisynthetase syndrome.

Review

Brain Calcifications in Adult-Onset Genetic Leukoencephalopathies: A Review

Abstract Full Text
JAMA Neurol. 2017;74(8):1000-1008. doi:10.1001/jamaneurol.2017.1062

This review assesses the importance of cerebral calcifications associated with white matter hyperintensities on magnetic resonance imaging in patients with adult-onset genetic leukoencephalopathies and leukodystrophies.

Research Letter

Safety and Efficacy of Bortezomib in Patients With Highly Relapsing Neuromyelitis Optica Spectrum Disorder

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):1010-1012. doi:10.1001/jamaneurol.2017.1336

This study examines the safety and efficacy of bortezomib in patients with highly relapsing neuromyelitis optica spectrum disorder.

Comment & Response

Confusing Terminology—Neuroleptic Malignant Syndrome vs Malignant Hyperthermia

Abstract Full Text
JAMA Neurol. 2017;74(8):1012-1013. doi:10.1001/jamaneurol.2017.0822

Confusing Terminology—Neuroleptic Malignant Syndrome vs Malignant Hyperthermia—Reply

Abstract Full Text
JAMA Neurol. 2017;74(8):1013. doi:10.1001/jamaneurol.2017.0825

Crowdsourcing the Million Brains Initiative

Abstract Full Text
JAMA Neurol. 2017;74(8):1013-1014. doi:10.1001/jamaneurol.2017.0992

Crowdsourcing the Million Brains Initiative—Reply

Abstract Full Text
JAMA Neurol. 2017;74(8):1014. doi:10.1001/jamaneurol.2017.0995

Mechanical Thrombectomy After Intravenous Thrombolysis vs Mechanical Thrombectomy Alone in Acute Stroke

Abstract Full Text
JAMA Neurol. 2017;74(8):1014-1015. doi:10.1001/jamaneurol.2017.1340

Mechanical Thrombectomy After Intravenous Thrombolysis vs Mechanical Thrombectomy Alone in Acute Stroke—Reply

Abstract Full Text
JAMA Neurol. 2017;74(8):1015. doi:10.1001/jamaneurol.2017.1343
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2017;74(8):890. doi:10.1001/jamaneurol.2016.4010
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