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September 2020 - July 1959

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Issue

January 2018, Vol 75, No. 1, Pages 5-133

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2018;75(1):5. doi:10.1001/jamaneurol.2017.1121
Viewpoint

The Parkinson Pandemic—A Call to Action

Abstract Full Text
JAMA Neurol. 2018;75(1):9-10. doi:10.1001/jamaneurol.2017.3299

This Viewpoint details the growing prevalance of Parkinson disease and outlines guiding efforts to help combat the pandemic.

Public Health Interventions for Decreasing Dementia Risk

Abstract Full Text
JAMA Neurol. 2018;75(1):11-12. doi:10.1001/jamaneurol.2017.3303

This Viewpoint describes the current public health burden of dementia and the recent insights and ongoing research needs for effective, appropriate prevention.

On the Brain

Rethinking Eligibility for Experimental Clinical Trials

Abstract Full Text
JAMA Neurol. 2018;75(1):22-23. doi:10.1001/jamaneurol.2017.3492

This essay describes a patient’s account of experimental clinical trials for spinal muscular atrophy.

Editorial

Leaving Tiny, Unruptured Intracranial Aneurysms Untreated: Why Is It So Hard?

Abstract Full Text
JAMA Neurol. 2018;75(1):13-14. doi:10.1001/jamaneurol.2017.2559

Combating the Spread of Ineffective Medical Procedures: A Lesson Learned From Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2018;75(1):15-17. doi:10.1001/jamaneurol.2017.3066

Challenges in Communicating and Understanding Predictive Biomarker Imaging for Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2018;75(1):18-19. doi:10.1001/jamaneurol.2017.2558

Informing vs Changing the Practice of Carotid Revascularization

Abstract Full Text
JAMA Neurol. 2018;75(1):20-21. doi:10.1001/jamaneurol.2017.3298
Original Investigation

Management of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis

Abstract Full Text
free access
JAMA Neurol. 2018;75(1):27-34. doi:10.1001/jamaneurol.2017.3232

This comparative effectiveness analysis evaluates the effectiveness of routine treatment (aneurysm coiling) vs 3 different strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny unruptured intracranial aneurysms.

Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2018;75(1):35-43. doi:10.1001/jamaneurol.2017.3825

This randomized clinical trial determines the efficacy and safety of venous percutaneous transluminal angioplasty in patients with multiple sclerosis with chronic cerebrospinal venous insufficiency.

Comprehension of an Elevated Amyloid Positron Emission Tomography Biomarker Result by Cognitively Normal Older Adults

Abstract Full Text
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JAMA Neurol. 2018;75(1):44-50. doi:10.1001/jamaneurol.2017.2954

This study examines comprehension of an elevated amyloid positron emission tomographic biomarker result by cognitively unimpaired older adults to inform the processes of describing Alzheimer disease biomarkers to cognitively normal adults and assessing their understanding of this knowledge.

National Patterns of Carotid Revascularization Before and After the Carotid Revascularization Endarterectomy vs Stenting Trial (CREST)

Abstract Full Text
free access has active quiz
JAMA Neurol. 2018;75(1):51-57. doi:10.1001/jamaneurol.2017.3496

This population-based study compares the use of coronary artery stenting in elderly patients between the years before and after publication of the Carotid Revascularization Endarterectomy vs Stenting Trial (CREST).

Association Between Decline in Slow Vital Capacity and Respiratory Insufficiency, Use of Assisted Ventilation, Tracheostomy, or Death in Patients With Amyotrophic Lateral Sclerosis

Abstract Full Text
open access
JAMA Neurol. 2018;75(1):58-64. doi:10.1001/jamaneurol.2017.3339

This study investigates the rate of decline in percentage predicted slow vital capacity and its association with respiratory-related clinical events and mortality in patients with amyotrophic lateral sclerosis.

Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease

Abstract Full Text
free access has active quiz
JAMA Neurol. 2018;75(1):65-71. doi:10.1001/jamaneurol.2017.3196

The case series describes myelin oligodendrocyte glycoprotein IgG– and aquaporin 4 IgG–associated disease in 134 English patients who presented with seizure.

Association of Brain Structure Changes and Cognitive Function With Combination Antiretroviral Therapy in HIV-Positive Individuals

Abstract Full Text
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JAMA Neurol. 2018;75(1):72-79. doi:10.1001/jamaneurol.2017.3036

This longitudinal case-control study examines whether detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with combination antiretroviral therapy.

Association of Cardiac Hemodynamic Factors With Severity of White Matter Hyperintensities in Chronic Valvular Heart Disease

Abstract Full Text
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JAMA Neurol. 2018;75(1):80-87. doi:10.1001/jamaneurol.2017.2853

This study investigates the association between chronically altered cardiac hemodynamics and the severity of cerebral white matter hyperintensity in patients with chronic valvular heart disease.

Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia

Abstract Full Text
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JAMA Neurol. 2018;75(1):88-96. doi:10.1001/jamaneurol.2017.3029

This longitudinal study in a subgroup of the Ginkgo Evaluation of Memory study compares the patterns of long-term cognitive decline in multiple domains by preclinical biomarker status in the oldest old without dementia.

Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study

Abstract Full Text
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JAMA Neurol. 2018;75(1):97-104. doi:10.1001/jamaneurol.2017.3229

This cross-sectional analysis among participants from the Offspring cohort of the Framingham Study assesses the association between prevalent nonalcoholic fatty liver disease and brain magnetic resonance imaging measures.

Neurologic Phenotypes Associated With Mutations in RTN4IP1 (OPA10) in Children and Young Adults

Abstract Full Text
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JAMA Neurol. 2018;75(1):105-113. doi:10.1001/jamaneurol.2017.2065

This case series describes the RTN4IP1 mutations found in 12 children and young adults with severe central nervous system diseases and describes the association of these mutations with neurologic phenotypes.

Brief Report

Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2018;75(1):114-118. doi:10.1001/jamaneurol.2017.3171

This randomized clinical trial evaluates the effect of sodium oxybate in treatment of debilitating excessive daytime sleepiness and disturbed nighttime sleep in patients with Parkinson disease.

Clinical Implications of Basic Neuroscience Research

Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury

Abstract Full Text
JAMA Neurol. 2018;75(1):119-122. doi:10.1001/jamaneurol.2017.3475

This review summarizes findings from studies that suggest that after central nervous system injury, mitochondria can be released into extracellular space as a “help-me signal” to augment recovery.

Images in Neurology

Spontaneous Disappearance of Large Lumbar Disk Herniation

Abstract Full Text
JAMA Neurol. 2018;75(1):123-124. doi:10.1001/jamaneurol.2017.3178

This case report describes a woman in her 40s whose large lumbar disk herniation was spontaneously absorbed 8 months after initial presentation.

JAMA Neurology Clinical Challenge

Recurrent Dysarthria and Ataxia in a Young Girl

Abstract Full Text
has active quiz
JAMA Neurol. 2018;75(1):125-126. doi:10.1001/jamaneurol.2017.3085

A girl with an unremarkable medical history presented with 1 week of drowsiness, double vision, and left cranial nerve VI and VII palsies and later presented with 2 weeks of dysarthria and progressive ataxia without change in mental status. What is your diagnosis?

Research Letter

Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease

Abstract Full Text
free access
JAMA Neurol. 2018;75(1):127-128. doi:10.1001/jamaneurol.2017.3363

This study examines the effect of LRRK2 risk variants on the age at onset of Parkinson disease.

Comment & Response

Bortezomib for Neuromyelitis Optica Spectrum Disorder: A New Therapeutic Option for the More Severe Forms?

Abstract Full Text
JAMA Neurol. 2018;75(1):128-129. doi:10.1001/jamaneurol.2017.3447

Bortezomib for Neuromyelitis Optica Spectrum Disorder: A New Therapeutic Option for the More Severe Forms?—Reply

Abstract Full Text
JAMA Neurol. 2018;75(1):129-130. doi:10.1001/jamaneurol.2017.3450

Bortezomib for Neuromyelitis Optica Spectrum Disorder: A New Therapeutic Option for the More Severe Forms?

Abstract Full Text
JAMA Neurol. 2018;75(1):129. doi:10.1001/jamaneurol.2017.3454

Sensitivity to the Deficits Associated With Traumatic Brain Injury or Chronic Traumatic Encephalopathy

Abstract Full Text
JAMA Neurol. 2018;75(1):130-131. doi:10.1001/jamaneurol.2017.3569

Sensitivity to the Deficits Associated With Traumatic Brain Injury or Chronic Traumatic Encephalopathy—Reply

Abstract Full Text
JAMA Neurol. 2018;75(1):131-132. doi:10.1001/jamaneurol.2017.3572

Further Actions Are Needed to Prevent Maternal Deaths From Epilepsy

Abstract Full Text
JAMA Neurol. 2018;75(1):132-133. doi:10.1001/jamaneurol.2017.3621
Correction

Incorrect Affiliation

Abstract Full Text
free access
JAMA Neurol. 2018;75(1):133. doi:10.1001/jamaneurol.2017.3563

Omitted Funding Information

Abstract Full Text
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JAMA Neurol. 2018;75(1):133. doi:10.1001/jamaneurol.2017.3677

Correction of Author’s Name

Abstract Full Text
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JAMA Neurol. 2018;75(1):133. doi:10.1001/jamaneurol.2017.4634
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2018;75(1):7. doi:10.1001/jamaneurol.2017.1122
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