This Viewpoint details the growing prevalance of Parkinson disease and outlines guiding efforts to help combat the pandemic.
This Viewpoint describes the current public health burden of dementia and the recent insights and ongoing research needs for effective, appropriate prevention.
This essay describes a patient’s account of experimental clinical trials for spinal muscular atrophy.
This comparative effectiveness analysis evaluates the effectiveness of routine treatment (aneurysm coiling) vs 3 different strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny unruptured intracranial aneurysms.
This randomized clinical trial determines the efficacy and safety of venous percutaneous transluminal angioplasty in patients with multiple sclerosis with chronic cerebrospinal venous insufficiency.
This study examines comprehension of an elevated amyloid positron emission tomographic biomarker result by cognitively unimpaired older adults to inform the processes of describing Alzheimer disease biomarkers to cognitively normal adults and assessing their understanding of this knowledge.
This population-based study compares the use of coronary artery stenting in elderly patients between the years before and after publication of the Carotid Revascularization Endarterectomy vs Stenting Trial (CREST).
This study investigates the rate of decline in percentage predicted slow vital capacity and its association with respiratory-related clinical events and mortality in patients with amyotrophic lateral sclerosis.
The case series describes myelin oligodendrocyte glycoprotein IgG– and aquaporin 4 IgG–associated disease in 134 English patients who presented with seizure.
This longitudinal case-control study examines whether detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with combination antiretroviral therapy.
This study investigates the association between chronically altered cardiac hemodynamics and the severity of cerebral white matter hyperintensity in patients with chronic valvular heart disease.
This longitudinal study in a subgroup of the Ginkgo Evaluation of Memory study compares the patterns of long-term cognitive decline in multiple domains by preclinical biomarker status in the oldest old without dementia.
This cross-sectional analysis among participants from the Offspring cohort of the Framingham Study assesses the association between prevalent nonalcoholic fatty liver disease and brain magnetic resonance imaging measures.
This case series describes the RTN4IP1 mutations found in 12 children and young adults with severe central nervous system diseases and describes the association of these mutations with neurologic phenotypes.
This randomized clinical trial evaluates the effect of sodium oxybate in treatment of debilitating excessive daytime sleepiness and disturbed nighttime sleep in patients with Parkinson disease.
This review summarizes findings from studies that suggest that after central nervous system injury, mitochondria can be released into extracellular space as a “help-me signal” to augment recovery.
This case report describes a woman in her 40s whose large lumbar disk herniation was spontaneously absorbed 8 months after initial presentation.
A girl with an unremarkable medical history presented with 1 week of drowsiness, double vision, and left cranial nerve VI and VII palsies and later presented with 2 weeks of dysarthria and progressive ataxia without change in mental status. What is your diagnosis?
This study examines the effect of LRRK2 risk variants on the age at onset of Parkinson disease.
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