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April 2023 - July 1959




October 2018, Vol 75, No. 10, Pages 1165-1287

In This Issue of JAMA Neurology


Abstract Full Text
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JAMA Neurol. 2018;75(10):1165. doi:10.1001/jamaneurol.2017.2661

Expanding Access to Magnetic Resonance Imaging for Patients With Cardiac Rhythm Devices

Abstract Full Text
JAMA Neurol. 2018;75(10):1173-1174. doi:10.1001/jamaneurol.2018.1651

This Viewpoint describes the role of neurologists in implementing improved access to magnetic resonance imaging for patients with cardiovascular implantable electronic devices.

Newborn Screening and Emerging Therapies for X-Linked Adrenoleukodystrophy

Abstract Full Text
JAMA Neurol. 2018;75(10):1175-1176. doi:10.1001/jamaneurol.2018.1585

This Viewpoint discusses emerging therapies for X-linked adrenoleukodystrophy, an inherited disorder affecting the adrenals and nervous system white matter, and empahsizes the importance of newborn screening.

On the Brain

A Bowl of Oranges

Abstract Full Text
JAMA Neurol. 2018;75(10):1177-1178. doi:10.1001/jamaneurol.2018.2520

This personal narrative shares insights gleaned after the author’s father, a patient with Parkinson disease, experiences a cervical spine fracture that mandates a complicated hospitalization.


Cluster Headache and Calcitonin Gene-Related Peptide—More on Quantum Therapeutics in Headache Medicine

Abstract Full Text
JAMA Neurol. 2018;75(10):1179-1180. doi:10.1001/jamaneurol.2018.1428

Challenges in Passive Immunization Strategies to Treat Parkinson Disease

Abstract Full Text
JAMA Neurol. 2018;75(10):1180-1181. doi:10.1001/jamaneurol.2018.0346

A New Tool for Clinical Neuroscience—Synaptic Imaging

Abstract Full Text
JAMA Neurol. 2018;75(10):1181-1183. doi:10.1001/jamaneurol.2018.1643
Original Investigation

Effect of Infusion of Calcitonin Gene-Related Peptide on Cluster Headache Attacks: A Randomized Clinical Trial

Abstract Full Text
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JAMA Neurol. 2018;75(10):1187-1197. doi:10.1001/jamaneurol.2018.1675

This randomized clinical trial examines whether calcitonin gene-related peptide induces cluster headache attacks in episodic cluster headache in active phase, episodic cluster headache in remission phase, and chronic cluster headache.

Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography

Abstract Full Text
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JAMA Neurol. 2018;75(10):1198-1205. doi:10.1001/jamaneurol.2018.1578

This community-based cohort study explores the association between future declines in cognitive function and a thinner retinal nerve fiber layer in a large population of healthy UK adults.

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
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JAMA Neurol. 2018;75(10):1206-1214. doi:10.1001/jamaneurol.2018.1487

This randomized clinical trial evaluates the safety and tolerability of multiple intravenous infusions of PRX002/RG7935 (anti–α-synuclein monoclonal) vs placebo in patients with idiopathic Parkinson disease.

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

Abstract Full Text
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JAMA Neurol. 2018;75(10):1215-1224. doi:10.1001/jamaneurol.2018.1836

This cross-sectional study compares synaptic vesicle glycoprotein 2A binding in the brains of participants with Alzheimer disease and cognitively normal participants using positron emission tomographic (PET) imaging.

Medical Attention Seeking After Transient Ischemic Attack and Minor Stroke Before and After the UK Face, Arm, Speech, Time (FAST) Public Education Campaign: Results From the Oxford Vascular Study

Abstract Full Text
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JAMA Neurol. 2018;75(10):1225-1233. doi:10.1001/jamaneurol.2018.1603

This population-based study investigates the association of public education with improving delays and failure in seeking medical attention among consecutive patients with first transient ischemic attack or stroke.

Assessment of a Targeted Gene Panel for Identification of Genes Associated With Movement Disorders

Abstract Full Text
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JAMA Neurol. 2018;75(10):1234-1245. doi:10.1001/jamaneurol.2018.1478

This study aims to develop and evaluate a targeted sequencing approach using a customized panel of genes associated with movement disorders.

Assessing Biological and Methodological Aspects of Brain Volume Loss in Multiple Sclerosis

Abstract Full Text
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JAMA Neurol. 2018;75(10):1246-1255. doi:10.1001/jamaneurol.2018.1596

This cohort study assesses the dynamics of brain volume loss after multiple sclerosis onset and evaluates the repeatability of brain volume loss estimates made via 2 magnetic resonance imaging protocols.

Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia: A Population-Based Study

Abstract Full Text
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JAMA Neurol. 2018;75(10):1256-1263. doi:10.1001/jamaneurol.2018.1563

This population-based study investigates the association of inner retinal layer thickness with prevalent and incident dementia in a general population of Dutch adults.

Assessment of the Utility of Ictal Magnetoencephalography in the Localization of the Epileptic Seizure Onset Zone

Abstract Full Text
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JAMA Neurol. 2018;75(10):1264-1272. doi:10.1001/jamaneurol.2018.1430

This medical record analysis investigates the utility and reliability of ictal magnetoencephalography in the localization of the epileptogenic zone among patients experiencing epileptic seizures.


Advances in Understanding the Pathophysiology of Lacunar Stroke: A Review

Abstract Full Text
JAMA Neurol. 2018;75(10):1273-1281. doi:10.1001/jamaneurol.2018.1073

This narrative review of studies of cerebral small vessel disease published since 2012 investigates progress in understanding the pathogenesis, imaging characteristics, and genetic basis of lacunar stroke.

Images in Neurology

Selenium Toxicity Associated With Reversible Leukoencephalopathy and Cortical Blindness

Abstract Full Text
JAMA Neurol. 2018;75(10):1282-1283. doi:10.1001/jamaneurol.2018.1669

This case report describes a woman in her early 50s who presented with 2 months of progressive cognitive impairment and visual loss.

JAMA Neurology Clinical Challenge

Subacute Progressive Ptosis, Ophthalmoplegia, Gait Instability, and Cognitive Changes

Abstract Full Text
JAMA Neurol. 2018;75(10):1284-1285. doi:10.1001/jamaneurol.2018.1588

A 70-year-old woman with long-term tobacco use presented with 2 weeks of bilateral ptosis and binocular horizontal diplopia and moderate exotropia, severe bilateral ptosis, impaired bilateral adduction and vertical ductions, and impaired convergence. What is your diagnosis?

Research Letter

Media Dissemination of the Montreal Cognitive Assessment After President Donald Trump’s Medical Evaluation

Abstract Full Text
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JAMA Neurol. 2018;75(10):1286-1287. doi:10.1001/jamaneurol.2018.1777

This study presents data on the surge in interest in the Montreal Cognitive Assessment in the wake of news about US President Donald Trump undergoing this test.


Error in Data Presentation in Text

Abstract Full Text
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JAMA Neurol. 2018;75(10):1287. doi:10.1001/jamaneurol.2018.2697
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2018;75(10):1166. doi:10.1001/jamaneurol.2017.2662