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August 2019 - July 1959

Decade

Year

Issue

June 2018, Vol 75, No. 6, Pages 639-763

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):639. doi:10.1001/jamaneurol.2017.2641
Viewpoint

Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2018;75(6):650-651. doi:10.1001/jamaneurol.2018.0602

This Viewpoint describes the issues surrounding the development of ocular biomarkers for Alzheimer disease.

On the Brain

Of Loss and Love—A Physician’s Odyssey of Spousal Caretaking

Abstract Full Text
JAMA Neurol. 2018;75(6):659-660. doi:10.1001/jamaneurol.2018.0476
Editorial

Antiepileptic Drugs in Pregnancy—Quick Decisions With Long-term Consequences

Abstract Full Text
JAMA Neurol. 2018;75(6):652-654. doi:10.1001/jamaneurol.2017.5060

Waking Up to the Importance of Sleep in the Pathogenesis of Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2018;75(6):654-656. doi:10.1001/jamaneurol.2018.0005

The Role of Regulatory T Lymphocytes in Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. 2018;75(6):656-658. doi:10.1001/jamaneurol.2018.0043
Original Investigation

Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):663-671. doi:10.1001/jamaneurol.2017.5035

This population-based study evaluates the association between school performance and maternal use of valproate in children exposed prenatally.

Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):672-680. doi:10.1001/jamaneurol.2018.0049

This cohort analysis assesses whether excessive daytime sleepiness at baseline is associated with longitudinal regional β-amyloid accumulation in elderly persons without dementia.

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):681-689. doi:10.1001/jamaneurol.2018.0035

This human and animal study assesses the role of regulatory T-cells in the pathophysiology of amyotrophic lateral sclerosis and the therapeutic association with increasing regulatory T-cell activity in a mouse model of the disease.

Effect of Treating Acute Optic Neuritis With Bioequivalent Oral vs Intravenous Corticosteroids: A Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA Neurol. 2018;75(6):690-696. doi:10.1001/jamaneurol.2018.0024

This randomized clinical trial assesses whether the administration of high-dose intravenous corticosteroid is superior to a bioequivalent oral corticosteroid dose for the treatment of patients with acute optic neuritis.

Prevalence of Invalid Performance on Baseline Testing for Sport-Related Concussion by Age and Validity Indicator

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):697-703. doi:10.1001/jamaneurol.2018.0031

This cross-sectional study investigates the prevalence of invalid performance on baseline testing for athletes aged 10 to 21 years who completed neurocognitive testing for the management of sport-related concussion.

Office-Based Screening for Dementia in Parkinson Disease: The Montreal Parkinson Risk of Dementia Scale in 4 Longitudinal Cohorts

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):704-710. doi:10.1001/jamaneurol.2018.0254

This cohort study presents an office-based screening tool for the risk of dementia in Parkinson disease.

Dual Antiplatelet Therapy in Transient Ischemic Attack and Minor Stroke With Different Infarction Patterns: Subgroup Analysis of the CHANCE Randomized Clinical Trial

Abstract Full Text
free access has active quiz
JAMA Neurol. 2018;75(6):711-719. doi:10.1001/jamaneurol.2018.0247

This imaging substudy of a randomized clinical trial investigates whether infarction patterns can be used to stratify the risk of recurrent stroke within 3 months of a transient ischemic attack or minor ischemic stroke.

Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2018;75(6):720-727. doi:10.1001/jamaneurol.2017.5153

This randomized clinical trial investigates whether standard vs intensive blood pressure lowering over 3 months causes decreased cerebral perfusion in small vessel disease.

Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):728-737. doi:10.1001/jamaneurol.2018.0395

This case-control study investigates the prevalence and type of learning disability in a cohort of patients with posterior cortical atrophy compared with patients with logopenic variant primary progressive aphasia and amnestic Alzheimer disease.

A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):738-745. doi:10.1001/jamaneurol.2018.0118

This case-control study assesses the use of an algorithm based on core Alzheimer disease cerebrospinal fluid measures to exclude cases with AD pathology and then differentiate between frontotemporal lobar degeneration tau and frontotemporal lobar degeneration transactive response DNA-binding protein.

Brief Report

Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab

Abstract Full Text
JAMA Neurol. 2018;75(6):746-750. doi:10.1001/jamaneurol.2018.0132

This case report highlights the diagnostic challenges and neuropathological findings in a fatal case of Powassan encephalitis caused by deer tick virus (lineage II) in a patient with follicular lymphoma receiving rituximab.

Review

Management of Gait Impairments in Chronic Unilateral Upper Motor Neuron Lesions: A Review

Abstract Full Text
has multimedia
JAMA Neurol. 2018;75(6):751-758. doi:10.1001/jamaneurol.2017.5041

This review offers a clinical guideline for treatment of gait impairments in adults with chronic unilateral upper motor neuron syndrome.

Images in Neurology

Frontoparietal Subdural Hematoma in a Child With Mental Regression

Abstract Full Text
JAMA Neurol. 2018;75(6):759-760. doi:10.1001/jamaneurol.2018.0139

This case report describes a 10-year-old boy who presented with progressive encephalopathy, deterioration in school performance, behavioral and personality changes, marked bradypsychia, and weight loss due to cobalamin D disease.

Observation

Listeria monocytogenes–Induced Rhombencephalitis in a Patient With Multiple Sclerosis Treated With Dimethyl Fumarate

Abstract Full Text
JAMA Neurol. 2018;75(6):762-763. doi:10.1001/jamaneurol.2018.0368

This case report describes a patient with relapsing-remitting multiple sclerosis treated with dimethyl fumarate who developed Listeria monocytogenes infection complicated by rhombencephalitis.

Correction

Missing Funding Information

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):763. doi:10.1001/jamaneurol.2018.0748

Error in Methods Section

Abstract Full Text
free access
JAMA Neurol. 2018;75(6):763. doi:10.1001/jamaneurol.2018.1161
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2018;75(6):641. doi:10.1001/jamaneurol.2017.2642
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