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December 2019 - July 1959




December 2019, Vol 76, No. 12, Pages 1411-1520

In This Issue of JAMA Neurology


Abstract Full Text
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JAMA Neurol. 2019;76(12):1411. doi:10.1001/jamaneurol.2018.3021

“It’s All in Your Head”—Medicine’s Silent Epidemic

Abstract Full Text
JAMA Neurol. 2019;76(12):1417-1418. doi:10.1001/jamaneurol.2019.3043

This Viewpoint discusses the harm of dismissing patients with medically unexplained symptoms and how to better support this population.

Imaging the Whole Genome in Diagnosing Neurologic Disorders

Abstract Full Text
JAMA Neurol. 2019;76(12):1419-1420. doi:10.1001/jamaneurol.2019.3117

This Viewpoint discusses the implications of whole-genome testing in determining diagnoses of neurologic diseases.


Benefits of Magnetic Resonance Imaging for Patients Presenting With Low-risk Transient or Persistent Minor Neurologic Deficits

Abstract Full Text
JAMA Neurol. 2019;76(12):1421-1423. doi:10.1001/jamaneurol.2019.2963

Getting the Right Patient to the Right Place in the Right Amount of Time—A Role for Both Mobile Stroke Units and Prehospital Clinical Scales

Abstract Full Text
JAMA Neurol. 2019;76(12):1424-1425. doi:10.1001/jamaneurol.2019.2839

Is Hyperselection of Patients the Right Strategy?

Abstract Full Text
JAMA Neurol. 2019;76(12):1426-1427. doi:10.1001/jamaneurol.2019.0213
Original Investigation

Association of Concussion Symptoms With Testosterone Levels and Erectile Dysfunction in Former Professional US-Style Football Players

Abstract Full Text
open access has active quiz has audio
JAMA Neurol. 2019;76(12):1428-1438. doi:10.1001/jamaneurol.2019.2664

This cross-sectional study examines the association between self-reported concussion symptoms at the time of US-style football injury and self-reported low testosterone levels and erectile dysfunction indicators in US former professional football players.

Rate and Prognosis of Brain Ischemia in Patients With Lower-Risk Transient or Persistent Minor Neurologic Events

Abstract Full Text
has audio
JAMA Neurol. 2019;76(12):1439-1445. doi:10.1001/jamaneurol.2019.3063

This cohort study examines the frequency of acute infarction defined by diffusion restriction detected on magnetic resonance imaging scans among patients with low-risk, mild, or transient focal neurologic symptoms.

Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(12):1446-1456. doi:10.1001/jamaneurol.2019.2478

This cross-sectional European study evaluates the application of optimized magnetic resonance imaging protocols at 3 Tesla (T) for detecting and distinguishing MS from other conditions that mimic MS among adults.

Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2019;76(12):1457-1465. doi:10.1001/jamaneurol.2019.2764

This randomized clinical trial conducted in 9 countries compares the use of dabigatran with warfarin in stroke prevention among patients who just experienced cerebral venous thrombosis.

Outcomes Associated With Clopidogrel-Aspirin Use in Minor Stroke or Transient Ischemic Attack: A Pooled Analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trials

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(12):1466-1473. doi:10.1001/jamaneurol.2019.2531

This pooled analysis combines data from 2 randomized clinical trials to estimate the efficacy and risk of dual antiplatelet therapy after minor ischemic stroke or transient ischemic attack.

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Abstract Full Text
has multimedia
JAMA Neurol. 2019;76(12):1474-1483. doi:10.1001/jamaneurol.2019.2399

This cohort study examines association between chronic active lesions and clinical outcomes in US patients with multiple sclerosis.

Prehospital Stroke Management Optimized by Use of Clinical Scoring vs Mobile Stroke Unit for Triage of Patients With Stroke: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(12):1484-1492. doi:10.1001/jamaneurol.2019.2829

This randomized clinical trial explores how prehospital management optimized by the use of the Los Angeles Motor Scale compares with prehospital management in a mobile stroke unit that includes vascular imaging in accurately triaging patients with stroke to the appropriate target hospital providing (comprehensive stroke center) or not providing (primary stroke center) neurointerventional treatment.

Effect of Recombinant Activated Coagulation Factor VII on Hemorrhage Expansion Among Patients With Spot Sign–Positive Acute Intracerebral Hemorrhage: The SPOTLIGHT and STOP-IT Randomized Clinical Trials

Abstract Full Text
JAMA Neurol. 2019;76(12):1493-1501. doi:10.1001/jamaneurol.2019.2636

This randomized clinical trial investigates whether recombinant activated coagulation factor VII reduces hemorrhage expansion among patients with spot sign–positive intracerebral hemorrhage (ICH).

Brief Report

Association of Intracranial Pressure and Spontaneous Retinal Venous Pulsation

Abstract Full Text
JAMA Neurol. 2019;76(12):1502-1505. doi:10.1001/jamaneurol.2019.2935

This study determines whether infrared video assessment of spontaneous retinal venous pulsation is associated with intracranial pressure and is a valid tool to indicate the presence or absence of raised intracranial pressure in patients without papilledema.


Ethical Challenges of Risk, Informed Consent, and Posttrial Responsibilities in Human Research With Neural Devices: A Review

Abstract Full Text
JAMA Neurol. 2019;76(12):1506-1514. doi:10.1001/jamaneurol.2019.3523

This narrative review discusses analysis of risk, informed consent, and posttrial responsibilities to research participants in neural devices research.

Images in Neurology

The Mask Sign—An Imaging Marker of Traumatic Spinal Cord Hemorrhage

Abstract Full Text
JAMA Neurol. 2019;76(12):1515-1516. doi:10.1001/jamaneurol.2019.3320

This case report describes an unusual sign on magnetic resonance imaging that characterizes a particular type of injury.

JAMA Neurology Clinical Challenge

Orofacial Dyskinesia in a Young Man

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2019;76(12):1517-1518. doi:10.1001/jamaneurol.2019.3072

A 30-year-old man presents with involuntary orofaciolingual movements for 7 years and unsteady gait for 2 months. What is your diagnosis?

Comment & Response

Cautious Interpretation of Observational Data

Abstract Full Text
JAMA Neurol. 2019;76(12):1519. doi:10.1001/jamaneurol.2019.3456

Cautious Interpretation of Observational Data—Reply

Abstract Full Text
JAMA Neurol. 2019;76(12):1519-1520. doi:10.1001/jamaneurol.2019.3459

Error in Byline

Abstract Full Text
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JAMA Neurol. 2019;76(12):1520. doi:10.1001/jamaneurol.2019.3698

Incorrect Affiliation

Abstract Full Text
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JAMA Neurol. 2019;76(12):1520. doi:10.1001/jamaneurol.2019.3726

Error in Affiliation

Abstract Full Text
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JAMA Neurol. 2019;76(12):1520. doi:10.1001/jamaneurol.2019.3877

Errors in Table and Supplemental Figure

Abstract Full Text
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JAMA Neurol. 2019;76(12):1520. doi:10.1001/jamaneurol.2019.4331
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2019;76(12):1412. doi:10.1001/jamaneurol.2018.3022