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August 2019 - July 1959

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Issue

February 2019, Vol 76, No. 2, Pages 129-237

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2019;76(2):129. doi:10.1001/jamaneurol.2018.2971
Viewpoint

The US Food and Drug Administration’s Authorization of the First Cannabis-Derived Pharmaceutical: Are We Out of the Haze?

Abstract Full Text
JAMA Neurol. 2019;76(2):135-136. doi:10.1001/jamaneurol.2018.3550

This Viewpoint discusses the US Food and Drug Administration’s approval of Epidiolex, the first cannabis-derived treatment, for 2 epilepsy syndromes and discusses wider implications.

Addressing Cultural Barriers to Diagnosis and Treatment of Epilepsy in Hispanic Communities

Abstract Full Text
JAMA Neurol. 2019;76(2):137. doi:10.1001/jamaneurol.2018.3919

This Viewpoint suggests approaches to cultural barriers in understanding epilepsy and seizures in Hispanic communities.

On the Brain

Walking Home

Abstract Full Text
JAMA Neurol. 2019;76(2):138-139. doi:10.1001/jamaneurol.2018.3925

This essay discusses the experience of a family member included in a medical visit.

Editorial

On the Link Between Concussions and Suicide

Abstract Full Text
JAMA Neurol. 2019;76(2):140-141. doi:10.1001/jamaneurol.2018.3445

Prevalence and Severity of Alzheimer Disease in Individuals With Down Syndrome

Abstract Full Text
JAMA Neurol. 2019;76(2):142-143. doi:10.1001/jamaneurol.2018.3443
Original Investigation

Association of Concussion With the Risk of Suicide: A Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(2):144-151. doi:10.1001/jamaneurol.2018.3487

This systematic review and meta-analysis assesses the risk of suicide after concussion and/or mild traumatic brain injury in a cohort of more than 700 000 individuals diagnosed with these conditions, compared with a cohort of more than 6.2 million individuals who had not been so diagnosed.

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

Abstract Full Text
open access
JAMA Neurol. 2019;76(2):152-160. doi:10.1001/jamaneurol.2018.3616

This study examines the association of dementia with mortality and examines factors associated with dementia predictors in adults with Down syndrome.

Effect of Intensive Patient Education vs Placebo Patient Education on Outcomes in Patients With Acute Low Back Pain: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(2):161-169. doi:10.1001/jamaneurol.2018.3376

This randomized, placebo-controlled clinical trial compares the effects of intensive vs placebo patient education as a part of first-line care among patients with acute low back pain who were recruited between 2013 and 2015 from various institutions in Sydney, Australia.

Effect of Cerebellar Stimulation on Gait and Balance Recovery in Patients With Hemiparetic Stroke: A Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(2):170-178. doi:10.1001/jamaneurol.2018.3639

This randomized clinical trial determines whether cerebellar intermittent θ-burst stimulation can improve balance and gait functions in patients with hemiparesis due to stroke.

Sex and Race Differences in the Association of Incident Ischemic Stroke With Risk Factors

Abstract Full Text
JAMA Neurol. 2019;76(2):179-186. doi:10.1001/jamaneurol.2018.3862

This cohort study of 25 789 black and white individuals in the United States examines the incidence and risk factors for ischemic stroke by sex and race.

Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment

Abstract Full Text
JAMA Neurol. 2019;76(2):187-193. doi:10.1001/jamaneurol.2018.3459

This population-based study examines the association of cerebrospinal fluid neurofilament light protein and neurogranin levels with the risk of mild cognitive impairment among participants in the Mayo Clinic Study of Aging.

Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2019;76(2):194-202. doi:10.1001/jamaneurol.2018.3661

This pooled data analysis of 7 randomized clinical trials of thrombectomy for acute ischemic stroke examines whether follow-up infarct volume mediates the relationship between endovascular therapy and functional outcome in patients with acute ischemic stroke.

Association of Severe Hydrocephalus With Congenital Zika Syndrome

Abstract Full Text
JAMA Neurol. 2019;76(2):203-210. doi:10.1001/jamaneurol.2018.3553

This case series describes clinical and imaging findings in 24 infants born with congenital Zika syndrome who developed hydrocephalus.

Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism

Abstract Full Text
has multimedia
JAMA Neurol. 2019;76(2):211-216. doi:10.1001/jamaneurol.2018.3777

This cohort study describes the efficacy and safety of internal globus pallidus deep brain stimulation in Filipino patients with severe X-linked dystonia parkinsonism and predominant dystonia.

Review

Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review

Abstract Full Text
JAMA Neurol. 2019;76(2):217-226. doi:10.1001/jamaneurol.2018.2848

This systematic review presents the epidemiologic characteristics, management, and prognosis of the neurologic manifestations associated with cerebrovascular fibromuscular dysplasia (ie, involving cervical or intracranial arteries) to guide future research priorities.

Images in Neurology

Myelin Oligodendrocyte Glycoprotein Antibody–Associated Demyelination Comorbid With Leber Hereditary Optic Neuropathy

Abstract Full Text
JAMA Neurol. 2019;76(2):227-228. doi:10.1001/jamaneurol.2018.3207

This case report describes a patient aged in the mid-20s with a unique sequel to a genetically established case of Leber hereditary optic neuropathy.

Neurodegeneration With Brain Iron Accumulation: A Novel Mutation in the Ceruloplasmin Gene

Abstract Full Text
JAMA Neurol. 2019;76(2):229-230. doi:10.1001/jamaneurol.2018.3230

This case study highlights the importance of associated clinical features, especially diabetes mellitus and anemia, in the diagnostic workup of neurodegeneration with brain iron accumulation.

Research Letter

Assessment of Proposed Changes to Evaluation and Management Billing Levels by Physician Specialty

Abstract Full Text
JAMA Neurol. 2019;76(2):231-232. doi:10.1001/jamaneurol.2018.3794

This study compares the current billing levels across specialties to estimate the financial impact of the proposal to collapse payment amounts for levels 2 to 5 evaluation and management services into single payments.

Video Assessment of the Frequency and Evaluations of Head Collision Events During the 2018 World Cup Tournament

Abstract Full Text
JAMA Neurol. 2019;76(2):232-234. doi:10.1001/jamaneurol.2018.3462

This study provides an analysis of head collisions between players in all 64 games in the 2018 World Cup tournament, as well as the frequency of evaluations by referees and clinicians after such collisions.

Observation

Aphasic Binary Reversals in Patients With Neurological Disease as a Barrier to Clinical Decision Making

Abstract Full Text
JAMA Neurol. 2019;76(2):234-235. doi:10.1001/jamaneurol.2018.3790

This case series details 3 cases of a communication barrier called binary reversals in patients with the nonfluent-agramatic variant of primary progressive aphasia.

Comment & Response

The Wide Spectrum of Functional Movement Disorders

Abstract Full Text
JAMA Neurol. 2019;76(2):235-236. doi:10.1001/jamaneurol.2018.3905

Consideration of Costs and Open-label Studies of Erenumab

Abstract Full Text
JAMA Neurol. 2019;76(2):236. doi:10.1001/jamaneurol.2018.4150

Consideration of Costs and Open-Label Studies of Erenumab—Reply

Abstract Full Text
JAMA Neurol. 2019;76(2):236-237. doi:10.1001/jamaneurol.2018.4141
Correction

Error in Results

Abstract Full Text
free access
JAMA Neurol. 2019;76(2):237. doi:10.1001/jamaneurol.2018.4362
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(2):130. doi:10.1001/jamaneurol.2018.2972
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