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January 2021 - July 1959




April 2019, Vol 76, No. 4, Pages 389-509

In This Issue of JAMA Neurology


Abstract Full Text
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JAMA Neurol. 2019;76(4):389. doi:10.1001/jamaneurol.2018.2981

Studies of Hydrocephalus Associated With Long-term Spaceflight May Provide New Insights Into Cerebrospinal Fluid Flow Dynamics Here on Earth

Abstract Full Text
JAMA Neurol. 2019;76(4):391-392. doi:10.1001/jamaneurol.2018.4891

This Viewpoint discusses the insight that can be gained into cerebrospinal fluid flow dynamics from the study of hydrocephalus associated with long-term spaceflight.

Legal and Policy Challenges to Addressing Cognitive Impairment in Federal Officials

Abstract Full Text
JAMA Neurol. 2019;76(4):392-393. doi:10.1001/jamaneurol.2018.4728

This Viewpoint discusses challenges to mandatory screening of US federal officials, including the US president, for cognitive impairment.

Toward Minimum Standards Guidelines for the Delivery of Neurological Care in Complex Humanitarian Settings

Abstract Full Text
JAMA Neurol. 2019;76(4):394-395. doi:10.1001/jamaneurol.2018.4596

This Viewpoint discusses the need for and steps to implement neurological care to persons who are forcibly displaced worldwide.

On the Brain

Helping My Husband Live and Die

Abstract Full Text
JAMA Neurol. 2019;76(4):396-397. doi:10.1001/jamaneurol.2019.0292

This essay discusses caring for a dying spouse.


JAMA Neurology—The Year in Review, 2018

Abstract Full Text
JAMA Neurol. 2019;76(4):398-399. doi:10.1001/jamaneurol.2019.0286

How Safe Is Safe Enough for Space and Health Care?Communication and Acceptance of Risk in the Real World

Abstract Full Text
JAMA Neurol. 2019;76(4):399-401. doi:10.1001/jamaneurol.2018.4405

Neural-Derived Extracellular Vesicles in Clinical Trials: Message in a Bottle

Abstract Full Text
JAMA Neurol. 2019;76(4):402-404. doi:10.1001/jamaneurol.2018.4325
Original Investigation

Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials

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JAMA Neurol. 2019;76(4):405-411. doi:10.1001/jamaneurol.2018.4510

This meta-analysis of individual patient data from 7 randomized clinical trials analyzes the rate of reperfusion after endovascular thrombectomy started at different intervals after symptom onset in patients with acute ischemic stroke.

Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution

Abstract Full Text
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JAMA Neurol. 2019;76(4):412-419. doi:10.1001/jamaneurol.2018.4882

This study maps spaceflight-induced intracranial extracellular free water (FW) shifts and evaluates changes in brain white matter diffusion measures in astronauts following spaceflight.

Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial

Abstract Full Text
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JAMA Neurol. 2019;76(4):420-429. doi:10.1001/jamaneurol.2018.4304

This secondary analysis of the Exenatide-PD trial assesses whether patients with Parkinson disease have augmented activity in brain insulin and protein kinase B signaling pathways.

Comparison of Clinical Care and In-Hospital Outcomes of Asian American and White Patients With Acute Ischemic Stroke

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JAMA Neurol. 2019;76(4):430-439. doi:10.1001/jamaneurol.2018.4410

This analysis compares the characteristics, care, and outcomes of Asian American and white patients with acute ischemic stroke at hospitals participating in the Get With The Guidelines–Stroke program.

Prediction Tools for Psychiatric Adverse Effects After Levetiracetam Prescription

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JAMA Neurol. 2019;76(4):440-446. doi:10.1001/jamaneurol.2018.4561

This open cohort study derives prediction models to estimate the risk of psychiatric adverse effects from levetiracetam use in patients with epilepsy.

Association of Thrombectomy With Stroke Outcomes Among Patient Subgroups: Secondary Analyses of the DEFUSE 3 Randomized Clinical Trial

Abstract Full Text
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JAMA Neurol. 2019;76(4):447-453. doi:10.1001/jamaneurol.2018.4587

This secondary analysis of a randomized clinical trial determines the association of thrombectomy among patients by age, symptom severity, time to randomization, arterial occlusive lesion location, and imaging modality.

Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders

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JAMA Neurol. 2019;76(4):454-461. doi:10.1001/jamaneurol.2018.4279

This longitudinal population-based cohort study investigates the risk of metabolic and cardiovascular disorders among individuals with Tourette syndrome or chronic tic disorder over a period of 40 years.

Association of Seizure Spread With Surgical Failure in Epilepsy

Abstract Full Text
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JAMA Neurol. 2019;76(4):462-469. doi:10.1001/jamaneurol.2018.4316

This cohort study examines the association of seizure spread with seizure recurrence after surgery in patients who underwent medial temporal resections for drug-resistant temporal lobe epilepsy.

Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease

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JAMA Neurol. 2019;76(4):470-479. doi:10.1001/jamaneurol.2018.4377

This study provides longitudinal clinical disease-course data and neuropathologic association for newly proposed Parkinson disease subtypes.

Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis

Abstract Full Text
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JAMA Neurol. 2019;76(4):480-491. doi:10.1001/jamaneurol.2018.4519

This case-control study examines whether the risk for intracerebral hemorrhage presented by apolipoprotein E ε4 and ε2 alleles varies by race/ethnicity.


Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease: A Review

Abstract Full Text
JAMA Neurol. 2019;76(4):492-500. doi:10.1001/jamaneurol.2018.3634

This narrative review discusses the limits of current cerebral cavernous malformation treatment and introduces findings from in vitro and in vivo studies that provide insight into cerebral cavernous malformation pathogenesis and indicate molecular mechanisms as potential therapeutic targets.

Images in Neurology

Coats Plus Syndrome

Abstract Full Text
JAMA Neurol. 2019;76(4):501. doi:10.1001/jamaneurol.2018.4610

This case report describes an infant who presented with intrauterine growth retardation, retarded psychomotor development, and seizures. The patient was diagnosed as having Coats-plus syndrome.

Thunderclap Headache and Cerebral Vasoconstriction Secondary to Pheochromocytoma

Abstract Full Text
JAMA Neurol. 2019;76(4):502-503. doi:10.1001/jamaneurol.2019.0001

A 31-year-old postpartum woman with a history of gestational diabetes and preeclampsia developed thunderclap headache after the birth of her first child and was diagnosed as having pheochromocytoma.

JAMA Neurology Clinical Challenge

A Woman in Her 40s With Transient Neurological Symptoms, Migraine Headaches, and Hearing Loss

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(4):504-505. doi:10.1001/jamaneurol.2019.0186

A 42-year-old white woman with a history of episodic migraine with visual aura presented for evaluation of transient right upper extremity weakness and word-finding difficulty. What is your diagnosis?

Comment & Response

Reporting of R2 Statistics for Mixed-Effects Regression Models

Abstract Full Text
JAMA Neurol. 2019;76(4):507. doi:10.1001/jamaneurol.2018.4720

Reporting of R2 Statistics for Mixed-Effects Regression Models—Reply

Abstract Full Text
JAMA Neurol. 2019;76(4):507-508. doi:10.1001/jamaneurol.2018.4723

Heroin Smoking Is Not Common in the United States

Abstract Full Text
JAMA Neurol. 2019;76(4):508. doi:10.1001/jamaneurol.2019.0183

Heroin Smoking is Not Common in the United States—Reply

Abstract Full Text
JAMA Neurol. 2019;76(4):509. doi:10.1001/jamaneurol.2019.0194

Typographical Error in Results

Abstract Full Text
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JAMA Neurol. 2019;76(4):509. doi:10.1001/jamaneurol.2019.0485

Error in Byline

Abstract Full Text
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JAMA Neurol. 2019;76(4):509. doi:10.1001/jamaneurol.2019.0575
Peer Reviewers List

JAMA Neurology Peer Reviewers in 2018

Abstract Full Text
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JAMA Neurol. 2019;76(4):e190155. doi:10.1001/jamaneurol.2019.0155
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2019;76(4):390. doi:10.1001/jamaneurol.2018.2982